How to Take TUDCA

How to Take TUDCA and the Best Time to Take for Maximum Effects

You've probably heard about the amazing benefits of TUDCA. It's a common supplement and a modern medical marvel, helping fight liver damage and reduce inflammation. But how should you use TUDCA? What’s the right dosage, the best time to take it, and important tips to get the most out of its benefits?


Key Takeaways

  • The safe dosage of TUDCA for supporting general health is approximately 15-20 mg/kg body weight [2].
  • TUDCA can be taken at various times throughout the day, either on an empty stomach or with food.
  • Avoid using TUDCA before drinking alcohol as it may cause liver damage.
  • TUDCA is suitable for those seeking a liver-protective supplement and individuals with liver or bile-related issues such as hepatitis, cirrhosis, or fatty liver.
  • Pregnant women, breastfeeding women, and children under 15 years old should avoid using TUDCA due to a lack of safety research.

What is TUDCA?

For centuries, traditional Chinese medicine has valued animal bile and used it in treatments. Bile acids are natural components of bile. TUDCA (Tauroursodeoxycholic Acid) is a water-soluble bile acid found naturally in the body.

It has potential benefits for various diseases like diabetes, obesity, and neurodegenerative disorders due to its protective effects on cells [1].

TUDCA supports liver function, protects liver cells from damage, and helps with bile-related disorders. It also reduces oxidative stress, prevents cell death, and lowers inflammation in various disease models [1].

How to Take TUDCA

How to Take TUDCA

How Much TUDCA Should You Take Per Day?

The dosage can vary based on individual needs. Here are some recommended dosages based on research:

  • To support general health benefits: 15-20 mg/kg body weight [2].
  • To support liver regeneration: 150-900 mg/day for 3 weeks to 2 years [3].
  • To help improve muscle and liver sensitivity to insulin: 250-1000 mg twice daily, taken 10-15 minutes after meals [2].
  • To support Parkinson's disease: Approximately 50 mg/kg/day, divided into three doses [2].

When Is the Best Time to Take TUDCA?

There's no definitive answer for the best time to take TUDCA. You can take it on an empty stomach or with meals if you experience discomfort.

Taking TUDCA with food might help your body absorb it better and reduce any stomach upset. Some studies have used TUDCA after meals and found it beneficial [2]. Ultimately, the timing depends on your body and preferences.

Should You Take TUDCA With or Without Food?

tudca with or without food

You can take TUDCA with or without food, depending on your diet and habits.

However, taking it with food, especially fatty foods, helps optimize absorption. A study found that a high-fat diet delays but enhances the absorption of TUDCA [4].

Who Should Take TUDCA?

  • People with liver issues like hepatitis, cirrhosis, or fatty liver can benefit from TUDCA.
  • Those undergoing liver-damaging treatments (e.g., steroids or other liver-toxic drugs, liver transplants) should consider TUDCA for liver health.
  • People looking to reduce cholesterol and improve heart health.

Who Shouldn’t Take TUDCA?

  • Pregnant or breastfeeding women should avoid TUDCA or consult a specialist first due to insufficient safety data.
  • Children under 15 years old should also avoid TUDCA as there is limited evidence of its safety for this group.

Things to Consider When Taking TUDCA

Avoid taking TUDCA before drinking alcohol, as this can harm the liver.

Although TUDCA is generally safe, some people might experience mild digestive issues like nausea, diarrhea, or stomach upset. These side effects are usually temporary.


TUDCA is a supplement with many benefits, especially for liver support and protection. It also helps reduce cholesterol and supports bile function. To get the best results, follow the recommended dosages and take TUDCA with meals to optimize absorption. This will help maintain stable levels of TUDCA in your blood and maximize its benefits.


[1] Kusaczuk, Magdalena. “Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives.” Cells, vol. 8, no. 12, 20 Nov. 2019,,
[2] Zangerolamo, Lucas, et al. “The Bile Acid TUDCA and Neurodegenerative Disorders: An Overview.” Life Sciences, vol. 272, May 2021, p. 119252,
[3] “Ursodeoxycholic Acid in Treatment of Non-Cholestatic Liver Diseases: A Systematic Review.” Journal of Clinical and Translational Hepatology, 28 Sept. 2016, Accessed 9 Mar. 2020.
[4] Huang, Liang, et al. “High-Fat Diets Enhance and Delay Ursodeoxycholic Acid Absorption but Elevate Circulating Hydrophobic Bile Salts.” Frontiers in Pharmacology, vol. 14, 17 Apr. 2023, Accessed 11 May 2024.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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