Research conducted on human subjects using a daily dose ranging from 200 to 600 mg has reported minimal adverse effects, such as gastrointestinal discomfort and itching. Tongkat Ali does have contraindications with certain medications for prostate cancer, male breast cancer, diabetes, heart disease, sleep apnea, kidney disease, and concomitant immunosuppressants. Talk to your healthcare providers if you are taking any medications before taking Tongkat Ali.
Furthermore, excessive use of Tongkat Ali may affect the liver. Excessive consumption of Tongkat Ali, primarily due to its content of eurycomanone, a psychoactive compound, can potentially lead to certain side effects in the human body. In this context, Eurycomanone has been observed to interfere with crucial metabolic processes, including the metabolism of nutrients and toxins. Excessive eurycomanone intake has been associated with side effects such as fatty liver disease, jaundice, and cirrhosis. Additionally, some individuals may experience alterations in their blood lipid levels. In severe instances, the excessive consumption of eurycomanone can lead to liver damage or even liver failure. It is important to exercise caution and adhere to recommended dosage guidelines when using Tongkat Ali to avoid these potential risks to the liver and overall health.