benefits of zembrin for sleep

Benefits Of Zembrin For Sleep & How To Use Zembrin For Sleep?

Zembrin is a natural plant extract used for centuries in traditional medicine for its calming and relaxing effects. Recently, it has gained popularity as a supplement for improving sleep quality and reducing insomnia. In this article, we will discuss the benefits of Zembrin for sleep and how to incorporate it into your bedtime routine.


Benefits of Zembrin for Sleep

A recent study examined the safety and tolerability of Sceletium Tortuosum (Zembrin) extract and benefits of Zembrin for sleep quality.

The study found that participants who took Zembrin reported an improvement in the subjective quality of their sleep, as measured by the HAM-D (Hamilton depression) scale. The data revealed that Zembrin had a positive effect on sleep onset compared to the placebo group. [1]

These findings suggest that Zembrin may be beneficial for enhancing sleep quality.

benefits of zembrin for women's sleep

How Does Zembrin Improve Your Sleep?

A recent study using functional magnetic resonance imaging (fMRI) has identified the specific brain-activating effects of Zembrin. When administered to healthy individuals, the Zembrin extract reduces the amygdala's response - an emotional reaction occurring in the body to cope with stress [1].

Furthermore, although the study participants had no history of insomnia, the data indicated that they experienced better sleep onset than the placebo group [1].

Consequently, Zembrin effectively reduces stress, facilitating easier and more restful sleep and improving overall sleep quality [1].

How is Zembrin Utilized for Sleep in Traditional and Modern Practices?

Historically, the San and Khoi people of South Africa used Sceletium to suppress hunger and enhance mental and physical endurance before undertaking notable physical feats. Additionally, this plant was often utilized to alleviate pain, elevate mood, and induce relaxation. [2]

San mothers commonly chew the root and transfer the juice into an infant's mouth to promote better sleep. [2]

Apart from utilizing the roots, people of African descent from Queenstown and the Khoisan from Namaqualand also employed an infusion of Sceletium Tortuosum leaves for pain relief [2].

The use of Zembrin for sleep in modern practice has not been established or studied as extensively as its potential applications for mood and stress.

Zembrin is primarily marketed by its producer, HG&H Pharmaceuticals, as a supplement with mood-enhancing and stress-reducing properties. While stress reduction and mood improvement may indirectly contribute to better sleep, specific recommendations regarding using Zembrin as a sleep aid may vary [1].

zembrin for good sleep

Other Zembrin's Benefits That You Should Know

Stress Reduction: Sceletium Tortuosum, the plant from which Zembrin is derived, has traditionally been used to alleviate stress and anxiety. Zembrin is thought to possess stress-reducing effects by modulating neurotransmitter systems in the brain. [3]

zembrin helps with reducing stress before sleep

Anxiolytic Effects: Zembrin may exhibit anxiolytic (anxiety-reducing) effects. Its interaction with serotonin receptors may contribute to this beneficial property. [4]

Cognitive Function: Zembrin may enhance cognitive function, including cognitive flexibility and executive function. [5]

Adaptogenic Properties: Zembrin is sometimes regarded as an adaptogen, a substance that aids the body in adapting to stress. [6]


Research suggests a positive correlation between Zembrin intake and improved sleep quality. These benefits of Zembrin for sleep include stress reduction, improved cognitive function, and adaptogenic properties. Consider adding Zembrin for sleep, but consult a healthcare professional before starting any new sleep supplement.


[1] ---. “Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary ExtractSceletium Tortuosum(Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia.” Evidence-Based Complementary and Alternative Medicine, vol. 2014, 2014, pp. 1–9,
[2] Smith, Michael T., et al. “Psychoactive Constituents of the Genus Sceletium N.E.Br. And Other Mesembryanthemaceae: A Review.” Journal of Ethnopharmacology, vol. 50, no. 3, Mar. 1996, pp. 119–130,
[3] Reay, J. L., Wetherell, M., Morton, E., Lillis, J., & Vladimir Badmaev. (2020). Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers. Human Psychopharmacology: Clinical and Experimental, 35(6), 1–7.
[4] Gericke, J., Harvey, B. H., Pretorius, L., Ollewagen, T., Benecke, R. M., & Smith, C. (2024). Sceletium tortuosum-derived mesembrine significantly contributes to the anxiolytic effect of Zembrin®, but its anti-depressant effect may require synergy of multiple plant constituents. Journal of Ethnopharmacology, 319, 117113–117113.
[5] Wilfried Dimpfel, Gericke, N., Suliman, S., & Gwladys N. Chiegoua Dipah. (2017). Effect of Zembrin® on Brain Electrical Activity in 60 Older Subjects after 6 Weeks of Daily Intake. A Prospective, Randomized, Double-Blind, Placebo-Controlled, 3-Armed Study in a Parallel Design. World Journal of Neuroscience, 07(01), 140–171.
[6] Wilfried Dimpfel, Schombert, L., & Gericke, N. (2016). Electropharmacogram of Sceletium tortuosum extract based on spectral local field power in conscious freely moving rats. Journal of Ethnopharmacology, 177, 140–147.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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