does hmb help with weight loss

Does HMB Help With Weight Loss? Dosage Of HMB For Weight Loss

HMB (beta-hydroxy beta-methylbutyrate) is a dietary supplement that has gained popularity recently for its potential benefits in bodybuilding and muscle gain. It is a metabolite of the essential amino acid leucine and is naturally produced by the body in small amounts. Recently, many people who are looking to lose weight often turn to supplements such as HMB to help them reach their goals, but does HMB help with weight loss effectively? And if so, what is the recommended dosage of HMB for weight loss? This document aims to answer these questions and provide the necessary information.


Key Takeaways

  • HMB is a dietary supplement that may aid in weight loss.
  • The exact mechanism of how HMB helps with weight loss is still being studied.
  • A recommended dosage for weight loss ranges from 1.5 to 3 grams per day, depending on individual factors such as body composition and exercise regimen.

hmb for weight loss

Does HMB Help with Weight Loss?

According to anecdotal reports and specific scientific studies, there are claims that HMB may assist in weight loss. However, the long-term weight loss benefits of HMB remain controversial and lack clear confirmation.

So, what does science say about the rumors surrounding the weight loss benefits of HMB? Let's delve into some prominent studies exploring HMB's effects on weight loss and weight management.

What Does Science Say About HMB For Weight Loss?

The research compares the effectiveness of HMB between two groups participating in resistance training for body strength and muscle damage.

The group using HMB showed increased fat-free weight and a better percent fat reduction than the placebo group [1]. Although the study indicated a decrease in fat mass, it did not claim that HMB contributed to weight loss.

In another study involving untrained participants using daily doses of 0, 1, and 3g combined with exercise, weight gains of 8%, 13%, and 18.4% were observed, with the most significant muscle mass increase at the 3g HMB dose [3].

However, a study on 40 obese women aged 20-45 recorded the effects of HMB on physique, weight, and muscle strength after 6 weeks of use. Interestingly, this study found that HMB helped reduce weight in obese women [2].

An experiment with mice using HMB noted effective weight reduction and positive effects on muscle loss. However, it's crucial to note that this study was conducted on mice with experimentally induced cancer cachexia [4].

A study involving female athletes showed significant weight reduction when consuming HMB-Ca under calorie-restricted conditions [6].

On the other hand, some studies did not report the significant effects of HMB on weight, whether gain or loss.

Gary J. Slater's comprehensive review discussed a study on HMB with a 3g/day dose in sedentary women, noting no changes in body weight [5]. Another experimental study with doses of 0.3 and 6g HMB per day over 28 days also showed no difference in total body weight [5].

Gary's review also mentioned that although supplementing with high doses of leucine (40g/day) led to weight and fat loss, it cannot be concluded that HMB alone contributes to fat mass reduction [5].

In summary, various studies present diverse results regarding benefits of HMB on weight management. While some show weight gain, others demonstrate weight loss, and some find no significant changes.

Here are some key insights that we have analyzed and extracted about HMB for fat loss and weight management. Please note that these insights are based on our subjective opinions.

  • Varying weight outcomes were observed, but most studies consistently report effective fat reduction with HMB.
  • HMB supports weight gain by increasing muscle mass, particularly in individuals engaged in training for muscle development.
  • Effective in aiding weight loss and improving physique, especially in obese individuals.
  • Enhanced effectiveness of HMB when combined with exercise.
  • The impact of HMB on weight is influenced by lifestyle, gender, age, and dosage.

HMB for weight management in women

How Does HMB Help With Weight Loss?

HMB has been shown to significantly impact muscle protein synthesis, which is the process of building and repairing muscles. This means that HMB can help prevent muscle breakdown during weight loss, preserving lean body mass while promoting fat loss [7].

Another way HMB may aid in weight loss is by improving exercise performance. Studies have shown that HMB can increase muscle strength and endurance, allowing individuals to perform better during workouts [8]. This leads to more calories being burned and potentially aiding in weight loss.

Additionally, another study on pigs discovered the effects of HMB for weight loss, which is particularly beneficial for obesity. This effectiveness is attributed to HMB's impact on the mechanisms induced by a high-fat diet (HFD) and insulin resistance mechanisms [7].

HMB Dosage For Weight Management And Fat Loss

There is no specific dosage for using HMB in weight management. However, for optimal effectiveness and safety, it is advisable to use a safe and sufficient dosage to yield results.

Through the analysis of various studies, we observed that the dosage commonly used ranges from 1000 to 3000 mg [3]. A study published in the Journal of the International Society of Sports Nutrition suggests that HMB is relatively safe, even for older adults and young children [6].

For individuals dealing with obesity or those aiming to improve their physique, combining HMB with regular exercise is recommended. It is evident from research that HMB does not significantly benefit individuals with low physical activity levels.


Does HMB Help With Cutting?

HMB can assist with cutting as it helps preserve lean muscle mass while promoting fat loss. It is particularly effective when combined with regular exercise and a balanced diet.

Does Hmb Help With Muscle Loss?

HMB is known to help prevent muscle loss. It boosts muscle protein synthesis, aiding in the building and repairing of muscles, which is particularly beneficial during weight loss or cutting phases when muscle mass can be compromised.

Does Hmb Work Immediately For Fat Loss?

HMB does not work immediately for fat loss. The effects of HMB on fat loss are typically observed over a sustained period of consistent use and physical exercise.


In conclusion, while the evidence for HMB's direct impact on weight loss is unclear, it has been shown to affect body composition positively. It may aid in muscle gain and fat loss when used with exercise and a balanced diet. Further research is needed to understand HMB's potential in weight management fully. However, current studies suggest that HMB can be a valuable supplement for individuals looking to improve their body composition and overall health.


[1] Panton, L. B., Rathmacher, J. A., Baier, S. M., & Nissen, S. (2000). Nutritional supplementation of the leucine metabolite β-hydroxy-β-methylbutyrate (hmb) during resistance training. Nutrition, 16(9), 734–739.
[2] Abolfazl Hashempour, Hooshmand, S., Mastaneh Rajabian Tabesh, & Alizadeh, Z. (2019). Effect of 6-week HMB (beta-hydroxy-beta methylbutyrate) supplementation on muscle strength and body composition in sedentary overweight women. Obesity Medicine, 15, 100115–100115.
[3] Wilson, G. J., Wilson, J. M., & Manninen, A. H. (2008). Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. Nutrition & Metabolism, 5(1).
[4] Muscaritoli. (2011). β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. International Journal of Oncology, 38(3).
[5] Slater, G. J., & Jenkins, D. G. (2000). ??-Hydroxy-F128b-Methylbutyrate (HMB) Supplementation and the Promotion of Muscle Growth and Strength. Sports Medicine, 30(2), 105–116.
[6] Wilson, J. M., Fitschen, P. J., Campbell, B., Wilson, G. J., Nelo Eidy Zanchi, Taylor, L., Wilborn, C., Kalman, D., Stout, J. R., Hoffman, J. R., Ziegenfuss, T. N., Lopez, H. L., Kreider, R. B., Smith‐Ryan, A. E., & José António. (2013). International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB). Journal of the International Society of Sports Nutrition, 10(1).
[7] Duan, Y., Zhong, Y., Xiao, H., Zheng, C., Song, B., Wang, W., Guo, Q., Li, Y., Han, H., Gao, J., Xu, K., Li, T., Yin, Y., Li, F., Yin, J., & Kong, X. (2019). Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets. The FASEB Journal, 33(9), 10019–10033.
[8] Park, B., Henning, P. C., Grant, S. C., Lee, W., Lee, S.-R., Arjmandi, B. H., & Kim, J. (2013). HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise. Metabolism, 62(12), 1718–1729.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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