How Long After Taking Tudca Can I Drink Alcohol

How Long After Taking Tudca Can I Drink Alcohol?

Tudca stands for Tauroursodeoxycholic acid. It is a water-soluble bile acid that is naturally present in the body and is derived from the conjugation of ursodeoxycholic acid (UDCA) with taurine, an amino acid. Bile acids, including Tudca, play essential roles in the digestion and absorption of dietary fats. Tudca has gained attention for its potential therapeutic properties, mainly supporting liver health. In this article, we will explore the question: "How long after taking Tudca can I drink alcohol?"


How Long After Taking Tudca Can I Drink Alcohol?

Studies do not specify how long after taking Tudca one can drink alcohol. Various online sources report different suggested times, with some indicating a minimum of 6 hours, while others suggest waiting a few hours or days.

The general consensus is that one should limit alcohol intake after using Tudca for safety purposes. In case alcohol is consumed, it is recommended to wait for at least three days to ensure no adverse effects occur.

However, it is essential to note that this is the author’s subjective opinion based on the gathered information. TUDCA users must seek the advice of healthcare professionals for an accurate assessment.

drink alcohol after taking tudca

Besides, based on a study conducted on patients using Tudca to treat liver disease, all participants had no history of alcohol abuse. Furthermore, the study also said to limit alcohol consumption in the months before and during the study [2].

Therefore, it is recommended to abstain from alcohol during treatment with Tudca for liver-related conditions.

However, for those using Tudca to support liver health daily, there is currently no research on the ideal amount of time to wait before drinking alcohol after taking Tudca.

After drinking, however, you can take Tudca – in fact, it may help protect your liver, reversing the adverse effects alcohol has on the vital organ.

The Relationship Between TUDCA and Alcohol

Tudca, a bile acid, has gained recognition for its potential to protect the liver. While it is well-known for its hepatoprotective effects, it is essential to note that it does not eliminate or negate the negative impact of alcohol on the liver.

Drinking alcohol can negatively impact the liver, causing inflammation, fatty liver disease, and, in severe cases, cirrhosis. [3] On the contrary, Tudca has been extensively researched for its ability to support liver cell health and potentially act as an antioxidant. [4]

However, it's essential to understand that Tudca does not provide a complete safeguard against the harmful effects of alcohol on the liver. Alcohol can still cause damage and stress to the liver, even if Tudca is being taken.

Why Do You Shouldn't Use Tudca Before Drinking Alcohol?

Many researchers mentioned avoiding taking Tudca (tauroursodeoxycholic acid) before drinking alcohol, as it can potentially cause liver damage.

Combining alcohol with Tudca may increase the risk of liver harm compared to alcohol consumption alone. Therefore, it is crucial to refrain from taking Tudca on any day when you plan to consume alcohol.

Alcohol itself can cause significant damage to the liver, leading to conditions such as fatty liver disease, hepatitis, and cirrhosis. Adding Tudca into the mix may further strain the liver's ability to process alcohol and metabolize its byproducts, potentially exacerbating liver damage.

Does Tudca Protect Liver From Alcohol?

Tauroursodeoxycholic acid (Tudca) has been identified for its potential protective effects on the liver, particularly in the context of alcohol-related damage. Tudca is suggested to exhibit liver-protective properties.

When present in relatively high concentrations, this acid can mitigate the toxic effects of ethanol and acetaldehyde, substances associated with alcohol metabolism. [1]

The protective mechanisms employed by Tudca are contributing to the reduction of toxicity resulting from alcohol consumption. While the exact tools require further investigation, these findings suggest a potential role for Tudca in safeguarding the liver against the harmful impacts of alcohol. [1]

potential role of Tudca for liver

Other Precautions And Side Effects Of Tudca

Although Tudca is generally safe for most individuals, it is essential to be aware of potential side effects and take necessary precautions. Some individuals may encounter digestive problems, including nausea, diarrhea, or stomach discomfort when using Tudca.

TUDCA can have adverse effects, such as hepatotoxicity, when taken in high doses. [5] Digestive issues, including diarrhea or constipation, are common side effects that some individuals may experience when using Tudca. [6]

When using TUDCA, pregnant or breastfeeding women need to avoid its use due to limited research on its safety in these populations. [7] Additionally, Tudca supplements are generally considered safe when taken in the recommended amounts.

How Much Tudca Should You Take?

It is worth noting that Tudca is generally well tolerated, and the majority of users do not experience any side effects when supplementing with the recommended 500 mg dose [9].

The recommended dosage of Tudca for patients with primary biliary cholangitis (PBC) is typically between 500 to 1,500 mg per day, as suggested by research [8].

To ensure optimal tolerance, it is advisable to begin with a lower dose and gradually increase it as tolerated. Taking Tudca with fatty meals can help support digestion and enhance its effectiveness.


In conclusion, the answer for “How many hours after taking Tudca can I drink alcohol?” is not specific because there are many reports about the timing. Also, Tudca has been studied extensively and has shown positive results in protecting the liver from various toxins, including alcohol. However, it is essential to exercise caution when combining Tudca with alcohol consumption and remember that Tudca should not be used as a means to protect the liver from alcohol consumption.


[1] Henzel, K., Thorborg, C., Hofmann, M., Zimmer, G., & Leuschner, U. (2004). Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1644(1), 37–45.
[2] Piero Portincasa, Palmieri, V. O., F. Doronzo, Gianluigi Vendemiale, Altomare, E., Sabbà, C., Palasciano, G., & Albano, O. (1993). Effect of tauroursodeoxycholic acid on serum liver enzymes and dyspeptic symptoms in patients with chronic active hepatitis. Current Therapeutic Research, 53(5), 521–532.
[3] Rocco, A., Compare, D., Angrisani, D., Marco Sanduzzi Zamparelli, & Nardone, G. (2014). Alcoholic disease: Liver and beyond. World Journal of Gastroenterology, 20(40), 14652–14652.
[4] Kusaczuk, M. (2019). Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives. Cells, 8(12), 1471–1471.
[5] Drack, A. V., Dumitrescu, A. V., Bhattarai, S., Gratie, D., Stone, E. M., Mullins, R. F., & Sheffield, V. C. (2012). TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice. Investigative Ophthalmology & Visual Science, 53(1), 100–100.
[6] Ashish Atreja, Fasihuddin, F., Shashank Garge, Davidoff, L., Rubin, J. M., Kakkar, S., Wedel, N., Divya Madisetty, Rohit Singhania, Jain, C., Sravya Kurra, & Sands, B. E. (2021). A POPULATION-BASED APPROACH TO DIGITAL OUTREACH, TRIAGE, AND MONITORING OF IBD PATIENTS DURING THE COVID-19 PANDEMIC. Inflammatory Bowel Diseases, 27(Supplement_1), S5–S5.
[7] Elia, A. E., Lalli, S., Maria Rosaria Monsurrò, Sagnelli, A., Alfonsa Claudia Taiello, Reggiori, B., Vincenzo La Bella, Tedeschi, G., & Albanese, A. (2015). Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis. European Journal of Neurology, 23(1), 45–52.
[8] Ma, H., Zeng, M., Han, Y., Hu, Y., Tang, H., Sheng, J., Hu, H.-P., Cheng, L., Xie, Q., Zhu, Y., Chen, G., Gao, Z., Xie, W., Wang, J., Wu, S., Wang, G., Miao, X., Fu, X., Duan, L., & Xu, J. (2016). A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine, 95(47), e5391–e5391.
[9] Larghi, A., Crosignani, A., Pier Maria Battezzati, Valle, G., Allocca, M., Pietro Invernizzi, Massimo Zuin, & Podda, M. (1997). Ursodeoxycholic and tauro‐ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. Alimentary Pharmacology & Therapeutics, 11(2), 409–414.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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