Lactobacillus Gasseri Benefits

Lactobacillus Gasseri Benefits - Dosage & Side Effects

Lactobacillus gasseri is a type of "good" bacteria that naturally exists in our bodies. It is predominantly found in the digestive tract, urinary tract, and genital area. This probiotic strain has been extensively studied for its potential health benefits, including improving gut health, boosting immunity, and aiding weight loss. This article will explore the numerous benefits of Lactobacillus Gasseri, its recommended dosage, and its potential side effects.

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What Is Lactobacillus Gasseri?

Lactobacillus gasseri is a type of probiotic bacteria that naturally resides in the human gastrointestinal tract. It is also often found in fermented foods like yogurt, kefir, and kimchi. Lactobacillus gasseri has been studied extensively for its potential health benefits. 

What Is Lactobacillus Gasseri

About Probiotic:

Probiotics consist of living microorganisms that offer health advantages when ingested in sufficient quantities. They are often referred to as "good" or "friendly" bacteria, and they work by helping balance the levels of bacteria in the gut. Probiotics have been found to support digestive health, boost the immune system, and even improve mental health. 

Lactobacillus is a type of several other probiotics. Other probiotics include:

  • Lactobacillus Acidophilus
  • Lactobacillus Rhamnosus
  • Bifidobacterium Bifidum
  • Streptococcus thermophilus
  • Saccharomyces boulardii

While Lactobacillus gasseri is naturally found within our bodies, it is also a common component in many fermented foods. Let's delve into how this beneficial probiotic is utilized in the food industry.

How Is Lactobacillus Gasseri Used In Food?

Lactobacillus gasseri is a probiotic bacterium frequently employed in various food items. This advantageous microorganism has demonstrated numerous health advantages, including enhancing digestive well-being and fortifying the immune system.

One of the prevalent applications of Lactobacillus gasseri in the food industry is as an initial culture in the fermentation of dairy products like yogurt, kefir, and cheese. These bacteria play a pivotal role in transforming lactose (the sugar found in milk) into lactic acid, which imparts the characteristic tangy taste to these products and assists in their preservation.

In addition to dairy products, Lactobacillus gasseri can also be found in other fermented foods like sauerkraut, kimchi, and pickles. These foods also undergo a similar fermentation process where Lactobacillus gasseri produces lactic acid, giving them their distinct tangy taste.

Lactobacillus Gasseri Can Be Found In Yogurt

In addition to its role in enhancing taste and preserving food, Lactobacillus gasseri offers potential health advantages to those who include it in their diet. As a probiotic, it contributes to maintaining a healthy gut microbiome by boosting the population of beneficial bacteria while decreasing the presence of harmful ones. This can result in better digestion, improved absorption of nutrients, and a reinforced immune system.

Besides its traditional uses in fermented foods, Lactobacillus gasseri is also being incorporated into a variety of functional food and beverage products. These include probiotic drinks, supplements, and even chewing gums. These products are marketed as a convenient way to get the benefits of Lactobacillus gasseri without consuming traditional fermented foods.

To explore the benefits of lactobacillus gasseri and how science talks about this, keep scrolling.

Lactobacillus gasseri Benefits

Handling Endometriosis And Supporting Vaginal Health

Lactobacillus Gasseri Supports Vaginal Health

Summary: Lactobacillus gasseri has been indicated to play a vital role in managing endometriosis, a condition that can lead to pain and fertility problems. Its probiotic activity aids in reducing inflammation, thereby potentially alleviating endometriosis symptoms. Furthermore, its beneficial effects extend to supporting vaginal health. L. gasseri contributes to maintaining a healthy vaginal microbiome, potentially preventing infections and promoting overall vaginal wellness.

Scientific Studies About Lactobacillus Gasseri Managing Endometriosis

Several studies suggest that Lactobacillus gasseri holds promising potential for inhibiting the development of endometriosis. One notable study by Hiroyuki Itoh [26] found that the continuous oral administration of L. gasseri OLL2809 for 21 days showed signs of inhibiting the development of ectopic endometrial lesions in a manner similar to that of IL-12. 

Additionally, another study conducted in mice observed complete healing results in two out of nine mice, while none in the control group showed such results. This finding infers the potential inhibitory effects of Lactobacillus gasseri OLL2809 (OLL2809) on the development of endometrial tissue [27]. 

In a randomized clinical trial assessing the efficacy of Lactobacillus gasseri OLL2809 in patients with endometriosis-related menstrual pain and abdominal pain, it was reported that the use of supplements containing L. gasseri OLL2809 contributed to the improvement of these conditions [28]. 

Promoting a Healthy Gut and Managing Diarrhea

Summary: The gut microbiome is a fragile equilibrium of both beneficial and harmful bacteria. When this equilibrium is disturbed, it can result in a range of health issues, including digestive issues, inflammation, and even chronic diseases. Lactobacillus gasseri fosters the development of advantageous bacteria in the gut, aiding in the preservation of a healthy balance.

Lactobacillus Gasseri Benefits For Promoting a Healthy Gut and Managing Diarrhea

Scientific Studies About Lactobacillus Gasseri Gut Health Benefits

Numerous scientific studies have unearthed the gut health benefits of Lactobacillus gasseri. A research piece titled "Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress" conducted on 60 Japanese medical students revealed that long-term usage of Lactobacillus gasseri CP2305 tablets could enhance mood, sleep, and gut microbiota in healthy adults under stressful conditions [1]. This finding holds particular promise for individuals with irritable bowel syndrome.

Another study discussed the significant improvements in cell toxicity in feces, the adherence of Salmonella bacteria to intestinal mucus in feces, and acute diarrhea due to the influence of L. gasseri. This evidence strengthens the potential usefulness of L. gasseri in enhancing specific gut health parameters [2].

A separate study titled "Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function" conducted on 120 individuals aged 20-63 observed noticeable enhancements in gut function and environment for healthy individuals prone to constipation or frequent urination [3].

Experimental studies on mice have also demonstrated the effectiveness of Lactobacillus gasseri. A study by Manabu Kawase and colleagues noted the favorable outcomes of Lactobacillus gasseri TNC0356 on immune responses in the gut and respiratory tract, thereby playing an essential role in virus resistance [4]. 

Another 2022 study conducted on mice with dextran sodium sulfate (DSS)-induced colitis concluded that the dosage of Lactobacillus gasseri G098 could reduce DSS-associated colitis by modulating the host's immune response and gut microbiota [5]. This research further suggests that Lactobacillus gasseri G098 treatment could be a potential strategy for managing inflammatory bowel disease (IBD).

Combating Fatigue And Improving Mental State, Sleep Quality

Summary: Persistent fatigue and stress can exert a substantial influence on mental well-being, potentially resulting in conditions like anxiety and depression. Research has indicated that Lactobacillus gasseri can play a role in alleviating these symptoms by diminishing inflammation in the body and stimulating the generation of mood-enhancing chemicals.

Lactobacillus Gasseri Improve Your Mental Health And Sleep Quality

Scientific Studies About Lactobacillus Gasseri Mental Health Benefits

A study conducted on Japanese male students to investigate the effects of Lactobacillus Gasseri CP2305 on improving mental and physical well-being, as well as sleep quality over a period of 4 weeks, reported significant changes in gene expression in peripheral blood leukocytes during the supplementation period. 

Additionally, the study observed substantial improvements in anxiety, depression, and overall sleep quality compared to the placebo group [6].

In a double-blind, randomized clinical trial involving two groups consuming yogurt containing probiotics Lactobacillus gasseri SBT22055 and Bifidobacteria longum SBT2928, positive results were achieved in the group consuming probiotic yogurt. This study recognized their benefits in enhancing innate immunity and reducing stress [7].

Supporting this hypothesis, another study conducted over five weeks on 21 men and 11 women also acknowledged the stress-reducing effects of CP2305. Specifically, the research noted improved sleep quality and diarrhea-related symptoms in males. 

Notably, while the study supported the effectiveness of Para-psychobiotic Lactobacillus gasseri CP2305 for both genders, it also mentioned that the impact on males was higher, and some stress symptoms were more severe in some female students. This was explained by specific cellular components of the body, leading to different reactions and outcomes [8].

Maintaining A Healthy Weight And Body Fat Percentage

Summary: Lactobacillus gasseri is touted for its potential role in weight management and reducing body fat. Studies have indicated that regular consumption of this probiotic can help regulate appetite and enhance metabolism, supporting healthy weight maintenance. It's believed to inhibit the absorption of dietary fat, steering it out of the body through feces rather than allowing the body to metabolize it. Furthermore, it may help to reduce abdominal fat and BMI, making it a promising adjunct in a comprehensive weight management plan.

Scientific Studies About Lactobacillus Gasseri Weight Management Benefits

The role of Lactobacillus gasseri in weight control has been investigated in numerous research studies. A study conducted by Ji-Hee Kang on mice demonstrated that Lactobacillus gasseri BNR17 could prevent weight gain caused by a high-fat diet, suggesting its potential as an alternative method to address weight and obesity issues [12].

A meta-analysis encompassing 17 human studies, 51 animal studies, and 14 experimental models also indicated an association between Lactobacillus gasseri and weight loss in obese humans and animals [13]. However, it was noted that different species of Lactobacillus may have varying effects, underscoring the need for consumers to exercise caution when purchasing products claiming to facilitate weight loss [13].

Another study aimed at evaluating the effect of Lactobacillus on weight loss and/or fat mass in overweight adults identified Lactobacillus gasseri as one of the strains influencing weight [14]. 

Furthermore, a paper by L. Crovesy and colleagues recognized the anti-obesity effects of L. gasseri BNR17 and highlighted its potential in managing diabetes [15]. This research adds another dimension to the health benefits of Lactobacillus gasseri, extending beyond gut health and mental wellness to weight management and metabolic health.

Managing Diabetics

Lactobacillus gasseri Aslo Benefits For Managing Diabetic

Summary: Lactobacillus gasseri shows promising results in managing diabetes. It aids in glucose metabolism, improving insulin resistance, and stabilizing blood sugar levels. Research has suggested its potential to reduce the risk of diabetes-related complications, making it a valuable addition to a comprehensive diabetes management plan.

Scientific Studies About Lactobacillus Gasseri Diabetes Management Benefits

A study conducted on diabetic mice noted that Lactobacillus gasseri BNR17 inhibited blood sugar levels and improved diabetes symptoms in mice. Consequently, the study also mentioned that lactic acid fermentation is expected to be beneficial as a therapy for type 2 diabetes in humans [9]. 

Additionally, research by M. Niibo and colleagues concluded that the LB2055 diet improved insulin secretion in diabetic mice by enhancing the pancreatic islet and serum inflammation status [10]. 

Furthermore, another study conducted on mice through oral administration for 14 days on Fermented Maillard Reaction Products by Lactobacillus gasseri 4M13 recognized the effectiveness of FMRP not only for type 2 diabetes but also for chronic inflammatory bowel disease (IBD) [11].

Moreover, another mouse study acknowledged the potential impact of L. gasseri CKCC1913 on metabolic health and highlighted its promising potential for diabetes. The study also suggested the need for further research in the future to focus on determining the optimal dosage and duration for this therapy [12].

While most studies on the effects of Lactobacillus gasseri have been conducted on animals and limited research on humans, the positive results and support from these studies have opened a potential avenue for supporting this condition.

Strengthening The Immune System

Lactobacillus Gasseri Plays A Vital Role In Bolstering The Immune System

Summary: Lactobacillus gasseri plays a vital role in bolstering the immune system. It aids in enhancing innate immunity and reducing stress, as demonstrated by a study involving probiotic yogurt [7]. Not only does it help in managing gut health and mental wellness, but it also shows promise in weight management, metabolic health, and diabetes management. Its potential as a therapeutic agent for type 2 diabetes is further emphasized by its ability to improve insulin secretion and regulate blood sugar levels [9][10][12].

Scientific Studies About Lactobacillus Gasseri Immune System Enhancement Benefits

Research has been conducted to explore the effectiveness of Lactobacillus gasseri in boosting the human immune system. One key study, titled "The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans", aimed to assess the impact of a fermented product containing Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711. 

The results suggested that the combination of these two strains enhances the activity of natural killer (NK) cells and the concentration of IgA. Notably, the efficacy of these effects was higher after two weeks of treatment compared to four weeks [16].

In another double-blind trial, researchers explored the potential of Lactobacillus gasseri TMC0356 to influence the immune response in elderly individuals. The outcomes of the study demonstrated that TMC0356 could increase the count of CD8+ T cells and decrease the expression of CD28 in CD8+ T cells among the elderly, thereby potentially augmenting their natural defense mechanisms against infectious diseases [17].

Dealing With H. Pylori Infection

Summary: Lactobacillus gasseri exhibits potential in addressing H. pylori infections, a common cause of peptic ulcers and certain types of stomach cancer. It's known to inhibit the growth of H. pylori, mitigate its virulence, and alleviate infection-induced inflammation. The probiotic properties of L. gasseri also help in restoring the gut microbiota balance disrupted by the infection. 

Scientific Studies About Lactobacillus Gasseri Combatting H. Pylori Infection

Various studies have further investigated the beneficial effects of Lactobacillus gasseri OLL 2716 (LG21) on H. pylori infection and gastritis. For instance, a research study conducted by Ichiko Sakamoto and colleagues demonstrated that LG21 not only suppresses the growth of H. pylori but also mitigates gastric mucosal inflammation [20]. 

Another research attested that a 4-week regimen of yogurt containing L. gasseri markedly improved the efficacy of triple therapy in patients with H. pylori infection [21]. 

Moreover, a study titled "Lactobacillus gasseri OLL2716 as a bioactive probiotic strain in Helicobacter pylori infection resistant to clarithromycin" discovered that L. gasseri functioned as a probiotic in cases of H. pylori infection that showed resistance to CAM (clarithromycin) [22]. 

Research has also delved into understanding the role of Lactobacillus gasseri OLL2716 in addressing Helicobacter pylori, a major contributor to a range of gastrointestinal illnesses, including gastric ulcers, duodenal ulcers, and gastric mucosa-related mucosa-associated lymphoid tissue (MALT) lymphoma. 

A particular study [19] concluded that Lactobacillus gasseri OLL2716 combats H. pylori by converting it into a coccoid form using dl-lactic acid. This mechanism of action effectively suppresses the pathogenic H. pylori, thereby providing a promising strategy to manage conditions associated with H. pylori infection.

These findings further underscore the potential of L. gasseri in managing conditions associated with H. pylori infection.

Addressing Ulcers

Summary: Lactobacillus gasseri demonstrates significant effectiveness in addressing ulcer-related issues, particularly those induced by H. pylori infections. Its probiotic properties facilitate the restoration of gut microbiota balance, thereby alleviating inflammation associated with peptic ulcers. Notably, it also mitigates gastric mucosal inflammation, augmenting the health of the stomach lining. The strain OLL2716 specifically suppresses H. pylori by converting it into a less harmful coccoid form, making L. gasseri a promising adjunct therapy in ulcer management.

Scientific Studies About Lactobacillus Gasseri Ulcer Prevention Benefits

Several scientific studies have shed light on the beneficial effects of Lactobacillus gasseri in relation to ulcers. A particular study on the effects of Yogurt Containing Lactobacillus gasseri OLL2716 recognized its efficacy in guarding the stomach and preventing the onset of acute gastric injury and gastric ulcers in mice [17]. This research also described endogenous prostaglandin as one of the protective mechanisms of LG21 yogurt for the stomach [17]. 

Additionally, a separate study on yogurt containing Lactobacillus gasseri OLL 2716 found an inhibition of acute gastric injury formation and a reduction of gastric mucosal damage caused by HCl. The findings suggest the necessity for live bacteria in accelerating the healing process of chronic gastric ulcers while not inhibiting the injuries to the gastric mucosa [18]. 

This evidence further underscores the diverse health advantages Lactobacillus gasseri offers, extending its therapeutic potential to include ulcer prevention and treatment.

Managing Allergies And Inflammatory Reactions

Summary: Lactobacillus Gasseri shows promise in managing allergies and inflammatory responses. It helps regulate immune responses, thus potentially reducing allergic reactions. Furthermore, its anti-inflammatory qualities may soothe inflamed tissues in the body, alleviating symptoms of various inflammatory conditions. This probiotic strain, therefore, holds potential for inclusion in allergy and inflammation management strategies, necessitating further research in these areas.

Scientific Studies About Lactobacillus Gasseri Allergy and Inflammation Management Benefits

Substantial research supports the effectiveness of Lactobacillus gasseri in managing inflammatory reactions and allergies. A representative study involving Lactobacillus gasseri MG4247 and Lactobacillus paracasei MG4272 and MG4577 in conditions such as hives, itching, runny nose, and allergy-related cough has shown that MG4272 and MG4577 exhibit probiotic characteristics capable of reducing cytokines associated with allergic inflammation [23]. 

Moreover, a specific study [24] provides evidence that oral consumption of L. gasseri can reduce key characteristics of respiratory allergy conditions caused by allergens and pre-inflammatory immune responses, such as IL-17, in asthmatic mice. 

Miao-Hsi Hsieh and colleagues' research also supports the notion that Lactobacilli can prevent early allergies in children and asthma. The study focused on the mechanism of L. gasseri and found that it can act through a newly activated PPARγ pathway in DCs to alleviate allergic respiratory inflammation in asthma [25]. 

These scientific findings enhance our understanding of the diverse health benefits offered by Lactobacillus gasseri, including its potential role in managing allergies and inflammation.

Lactobacillus gasseri Side Effects

Summary: Lactobacillus gasseri is a probiotic bacterium found in the human gut, and it has garnered attention for its potential health benefits, particularly in relation to digestive well-being and weight management. While it is generally regarded as safe, there may be some potential side effects associated with its consumption.

Potential Side Effects of Lactobacillus gasseri

  • Digestive Issues: As with any probiotic supplement, there is a possibility of experiencing digestive issues when taking lactobacillus gasseri. This may include symptoms such as bloating, gas, diarrhea, or constipation [29] [21]. These effects are usually temporary and should subside as your body adjusts to the supplement. If they persist, it is best to consult with your healthcare provider.
  • Allergic Reactions: While rare, some individuals may have an allergic reaction to lactobacillus gasseri. This can manifest as hives, itching, swelling, or difficulty breathing. If you experience these symptoms after taking lactobacillus gasseri, stop using immediately and seek medical attention.
  • Interference with Medications: Lactobacillus gasseri may interact with certain medications, particularly antibiotics. This is because probiotics can alter the balance of bacteria in the gut, potentially affecting the effectiveness of antibiotics [31]. 
  • Risk for Infection: While rare, there is a small risk of infection when taking probiotic supplements, including lactobacillus gasseri. This is more likely to occur in individuals with weakened immune systems or recently undergoing surgery [29].

How to Minimize Side Effects

To minimize the potential side effects of lactobacillus gasseri, it is important to follow these tips:

  • Start with a low dosage: Begin by taking a small dose of lactobacillus gasseri and gradually increase over time. This will allow your body to adjust to the supplement more easily.
  • Take it with food: Taking lactobacillus gasseri with a meal can help reduce the risk of digestive issues.
  • Consult with your healthcare provider: If you are experiencing side effects or have any concerns, it is important to discuss them with your healthcare provider. They can provide guidance on how to best incorporate lactobacillus gasseri into your health routine.

How Much Lactobacillus Gasseri Should I Take?

The appropriate dosage of lactobacillus gasseri may vary depending on your individual health needs and the specific supplement you are taking. It is always best to follow the recommended dosage on the product label, but here are some general guidelines to keep in mind:

  • For digestive health: The recommended daily dose for improving digestive health is typically between 1-10 billion CFUs (colony-forming units) per day [32].
  • For weight management: Studies have shown that taking 1 - 10 billion CFUs of lactobacillus gasseri daily may help reduce belly fat and body weight in overweight individuals [33].
  • For specific conditions: If you are taking lactobacillus gasseri for a specific health condition, it is important to consult with your healthcare provider for the appropriate dosage.

It is also important to note that the benefits of lactobacillus gasseri may not be seen immediately. It can take several weeks or even months of consistent use to see results, so it is important to be patient and continue taking the supplement as directed.

Who Should And Shouldn't Take Lactobacillus Gasseri?

As with any supplement, it is important to consult with your healthcare provider before starting to take lactobacillus gasseri. They can help determine if it is safe and appropriate for you based on your individual health status and any medications you are currently taking.

Generally, lactobacillus gasseri is considered safe for most healthy individuals. However, some groups of people should exercise caution or avoid taking it altogether, including:

  • Those with compromised immune systems: Probiotic supplements may not be safe for individuals with weakened immune systems, as they may increase the risk of infection [35].
  • People with certain medical conditions: If you have a serious medical condition such as cancer or an autoimmune disorder, it is important to consult with your healthcare provider before taking lactobacillus gasseri.
  • Pregnant or breastfeeding women: While there is limited research on the safety of lactobacillus gasseri during pregnancy and breastfeeding, it is best to avoid caution and consult with a healthcare provider before taking this supplement [21].

It is also important to carefully read product labels and avoid taking lactobacillus gasseri if you have any known allergies to the ingredients in the supplement.

How To Store Lactobacillus Gasseri?

To ensure the effectiveness of lactobacillus gasseri, it is important to store it properly. Here are some tips for storing this supplement:

  • Follow the manufacturer's instructions: Some probiotic supplements may have specific storage instructions on the product label. Be sure to follow these guidelines carefully.
  • Keep in a cool, dry place: Probiotics are live organisms that can be affected by heat, moisture, and light. Storing them in a cool, dry place away from direct sunlight is best.
  • Avoid extreme temperatures: Do not expose lactobacillus gasseri to extreme temperatures, as this can kill the live bacteria and render the supplement ineffective.
  • Check expiration dates: Be sure to check the expiration date on the product label and discard any expired supplements.

Conclusion

Lactobacillus gasseri is a probiotic supplement that holds the promise of various health advantages, such as enhanced digestion and weight control. Although generally deemed safe for most individuals in good health, it is crucial to seek advice from a healthcare professional before commencing this supplement. Adhering to appropriate storage instructions and beginning with a modest dosage can help reduce the potential adverse effects of lactobacillus gasseri while maximizing its potential advantages for your overall health and wellness.

FAQs

Is It Advisable For Everyone To Use Probiotics?

Probiotics, including lactobacillus gasseri, can be beneficial for most individuals, particularly in supporting digestive health. However, those with compromised immune systems or certain severe health conditions should consult a healthcare provider before starting any new supplement regimen. Pregnant or breastfeeding women should also seek medical advice prior to use.

What Products Contain Lactobacillus Gasseri?

Lactobacillus gasseri can be found in various probiotic supplements and fermented food products. Some of these include yogurts, sauerkraut, and specific types of cheese. Always check the product label for specific probiotic strains, including Lactobacillus Gasseri.

Can Lactobacillus Gasseri Help In Reducing Abdominal Fat?

Some studies suggest that Lactobacillus gasseri can aid in reducing abdominal fat. However, these findings are based on limited research, and more comprehensive studies are needed. Combining probiotic use with a balanced diet and regular exercise is essential for optimal health.

How Can You Naturally Obtain Lactobacillus Gasseri?

Lactobacillus Gasseri can be naturally obtained through the consumption of certain fermented foods. These include traditional Korean kimchi, certain types of yogurt, and fermented sausages. Always check the product label to ensure it contains this specific probiotic strain.

Is It Possible To Consume Too Much Lactobacillus Gasseri?

It is possible to consume too much Lactobacillus gasseri, which may lead to side effects like bloating, gas, or upset stomach. Always adhere to the recommended dosage and consult with a healthcare provider if you experience any adverse reactions.

Does Lactobacillus Gasseri Promote Hair Growth?

While no direct evidence suggests that Lactobacillus gasseri promotes hair growth, a healthy gut biome can positively impact overall health, including hair health. However, more research is required to fully understand the potential connection between probiotics such as Lactobacillus gasseri and hair growth.

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Author

Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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