lactobacillus salivarius benefits

Lactobacillus Salivarius Benefits & Side Effects And Dosage

Lactobacillus salivarius is a type of probiotic bacteria naturally found in the human body, particularly in the digestive tract. It belongs to the genus Lactobacillus and is one of the most common probiotic strains used in supplements and fermented foods. In this article, we will discuss the Lactobacillus salivarius benefits, side effects and its recommended dosage.

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What Is Lactobacillus Salivarius?

Lactobacillus salivarius is a type of bacteria that belongs to the Lactobacillus genus, which also includes other beneficial probiotic strains such as Lactobacillus acidophilus and Lactobacillus rhamnosus. It is an anaerobic, Gram-positive bacterium naturally found in the human body, especially in the mouth and gastrointestinal tract.

Lactobacillus Salivarius Benefits

Halitosis

The Effects Of Lactobacillus Salivarius On Halitosis

Halitosis, commonly known as bad breath, affects around half of the adult population worldwide and is often caused by bacteria in the mouth. L. salivarius has been studied for its potential use in treating halitosis due to its ability to inhibit the growth of certain oral bacteria.

In an open-label pilot trial involving 20 patients, the effects of Lactobacillus salivarius WB21 on halitosis and oral health were examined.

The results showed improved physiological halitosis and beneficial effects on gum bleeding when probing from the gingival pockets [11]. In this study, Lactobacilli were orally administered in tablet form with a daily dose of 2 billion CFU, along with xylitol, for a duration of 4 weeks [11].

Another study, which involved the treatment of L. salivarius G60 with or without inulin, also demonstrated promising results in subjective assessments of halitosis improvement [12].

It should be noted that some minor side effects, such as headaches, tongue discomfort, and diarrhea, were reported, although they were temporary [12].

Asthma

Lactobacillus Salivarius Benefits For Asthma

Asthma is a chronic respiratory condition that causes inflammation and constriction of the airways, leading to breathing difficulties.

Studies have shown that supplementation with Lactobacillus salivarius may help improve asthma symptoms by promoting anti-inflammatory effects and modulating immune responses.

A study conducted on mice examined the impact of Lactobacillus salivarius on Th1/Th2 cytokines, which are proteins that regulate immune responses in asthma patients.

The study suggests that giving Lactobacillus salivarius orally before allergen exposure could help reduce asthma symptoms in mice by balancing immune responses.

A trial with children with asthma investigated the effects of Ligilactobacillus salivarius LS01 and Bifidobacterium breve B632 alongside standard asthma medication. [3].

The trial's results documented the safety and efficacy of reducing the frequency of acute asthma exacerbations by one-third in 422 children using this probiotic combination for 8 weeks, with a combined dosage of more than 1 billion live cells per strain [3].

Cancer

Efficacy Of Lactobacillus Salivarius In Combating Cancer Cells

Numerous studies have examined the Lactobacillus salivarius benefits in combating cancer cells in humans and animals.

Encouragingly, inhibitory effects on the growth of cancer cells have been observed, particularly in colorectal, colon, and oral cancers.

It the inhibitory effects on cell proliferation, coupled with the apoptosis process of L. salivarius.

Significant reductions in the incidence rate of cancer were noted in a mouse study investigating the effects of Lactobacillus salivarius Ren on cancer prevention and gut microbiota.

When mice were administered a daily dose of 50 CFU/kg, the cancer incidence rate dropped from 87.5% to 25% [4].

Another study also concluded that LS inhibits the colorectal cancer process by suppressing the AKT signaling pathway.

This, in turn, hinders cell proliferation and triggers apoptosis—an immune process causing aging and death of cancer cells, resulting in the fragmentation and disappearance of their DNA [5].

The effectiveness of L. salivarius REN has also been explored in oral cancer. A mouse study revealed a significant 65% reduction in oral cancer incidence when administering a daily high dose of 50 billion CFU/kg [6].

Yajun Wang's study on oral cancer further supports this mechanism [7]. Both studies underscore the potential of Lactobacillus salivarius in combating oral cancer.

Atopic Dermatitis

Lactobacillus Salivarius Probiotic For Atopic Dermatitis

Atopic Dermatitis (AD) is a persistent inflammatory skin ailment that impacts approximately 15% to 20% of children globally. It is commonly referred to as eczema, recognized by red, itchy, and irritated skin.

AD can manifest at any point in life, but it predominantly emerges during infancy and childhood.

A placebo-controlled study investigated the therapeutic effects of Salivarius lactobacillus LS01 (DSM 22775) in treating atopic dermatitis (AD) in 38 adults.

The study utilized probiotics and placebos over a span of 16 weeks, with a dosage of 1 billion CFU twice daily.

The findings suggest that this specific probiotic strain may significantly modulate the Th1/Th2 cytokine profile, making it a potentially valuable complementary therapy for AD in adults [8].

In a preliminary assessment, 43 children with atopic dermatitis were treated with L. salivarius LS01 (DSM 22775) in freeze-dried form at a dosage of 2 sachets per day containing 1 billion CFU per sachet. After 20 weeks, significant improvements were observed [9].

 

Pylori Infection

L. Salivarius Inhibits The Growth Of H. Pylori

 

In addition to its potential use in treating gastrointestinal disorders, Lactobacillus salivarius has also been researched for its impact on H. pylori infection.

H. pylori is a common bacterium that can cause various digestive issues, such as gastritis and ulcers.

The mechanism by which L. salivarius inhibits the growth of H. pylori is believed to involve the production of bacteriocins and lactic acid. These substances create an unfavorable environment for the bacteria to thrive [13].

A study conducted by Yuji Aiba and colleagues utilized in vitro culture systems and a gnotobiotic mouse model infected with H. pylori.

The study discovered that Lactobacillus salivarius demonstrated a high capacity for lactic acid production, effectively inhibiting the growth of H. pylori in the body [13].

This inhibitory effect was achieved through the oral administration of Lactobacillus salivarius, resulting in reduced inflammation [13].

Another study focused on the specific inhibition of various Helicobacter pylori strains by Lactobacillus salivarius and other lactobacilli.

The research revealed that 9 out of 28 strains of L. salivarius and 3 out of 12 Lactobacillus species effectively inhibited H. pylori growth [14].

 

Mastitis

Lactobacillus salivarius Probiotic Benefits In Supporting Maternal Health

 

A study was conducted to evaluate the potential of Lactobacillus salivarius PS2 in preventing mastitis in women with a history of post-pregnancy infectious mastitis.

The findings concluded that oral consumption of L. salivarius PS2 during the late pregnancy period effectively prevents infectious mastitis in at-risk individuals [16].

In another trial, twenty women with staphylococcal mastitis were involved.

Promising results were observed after they were administered 1 billion CFU of Lactobacillus salivarius CECT5713 and a certain amount of Lactobacillus gasseri CECT5714 for four weeks [17].

Furthermore, a separate study with 352 women experiencing infectious mastitis reported positive outcomes about the effects of two probiotic strains, namely L. fermentum CECT5716 and L. salivarius CECT5713 [18].

Through these researches, various strain s of probiotic bacteria, including L. Salirius PS2, L. Salirius CECT5713, and L. fermentum CECT5716, have shown promising results in clinical trials.

Liver Function

In a study conducted by Cheng-Hung Chuang and colleagues, titled "Heat-Killed Lactobacillus salivarius and Lactobacillus johnsonii Reduce Liver Injury Induced by Alcohol In Vitro and In Vivo," promising findings were observed.

The study revealed a notable decrease in serum AST levels by up to 39.2%. These results support the assertion that both Lactobacillus salivarius and Lactobacillus johnsonii possess liver-protective properties against alcohol-induced damage, in laboratory and living organism experiments [19].

Additionally, the researchers evaluated the effects of L. salivarius Li01 consumption on mice with induced thioacetamide-induced acute liver damage. The findings displayed a significant reduction in serum ammonia and feces concentration in the Li01 group, accompanied by improvements in cognitive function and neuroinflammation [20].

Furthermore, a separate study investigated liver damage caused by D-galactosamine in mice. The study concluded that the remarkable properties of L. salivarius LI01 and P. pentosaceus LI05 make them potential biotherapeutics for the prevention and treatment of acute liver failure.

Notably, pretreatment with L. salivarius LI01 or P. pentosaceus LI05 significantly decreased alanine aminotransferase and aspartate aminotransferase levels [22].

How To Take Lactobacillus Salivarius Effectively?

Lactobacillus salivarius is available in various forms, including capsules, powders, and liquids. When selecting a product, reading the label and following the recommended dosage instructions is essential.

Lactobacillus salivarius supplements are commonly taken once or twice daily, with or without meals. The recommended dosage may differ based on the particular product and individual requirements. It's crucial to bear in mind that probiotics are not regulated by the FDA, making it vital to select a reputable brand from a trustworthy source.

Lactobacillus salivarius is also naturally present in specific fermented foods like yogurt, sauerkraut, and kefir. Regularly including these foods in your diet can serve as a natural source of this probiotic strain.

In addition to supplements and food sources, Lactobacillus salivarius can also be found in oral health products such as mouthwash or toothpaste. These products are specifically designed to promote oral health by introducing beneficial bacteria into the mouth.

With its potential benefits for various health concerns, this probiotic strain can be valuable to one's overall wellness plan. However, more research is needed to understand the lactobacillus salivarius side effects, benefits, and appropriate usage fully.

Lactobacillus Salivarius Side Effects and Dosage

The recommended Lactobacillus salivarius dosage varies depending on the specific product and intended use. The suggested daily intake ranges from 1-10 billion CFU for adults to avoid side effects.

Probiotics may have different effects on individuals, and in some cases, they can cause mild side effects such as gas or bloating. If these symptoms persist or become severe, it is recommended to discontinue use and consult a healthcare professional.

Individuals with compromised immune systems or chronic health conditions should consult a healthcare professional before taking Lactobacillus salivarius.

Moreover, pregnant or lactating women need to exercise caution as there is a lack of scientific studies regarding its safety for this specific group.

In addition, it is important to ensure the quality and safety of Lactobacillus salivarius supplements by purchasing them from reputable sources.

While this probiotic strain is generally considered safe for most individuals, exercising caution and seeking medical advice when needed is always advisable.

Conclusion

Lactobacillus salivarius is a promising probiotic strain that addresses health concerns. Extensive studies show its therapeutic effects, including support for maternal health, liver function, and oral well-being.

While more research is needed for a complete understanding of Lactobacillus salivarius side effects and benefits, incorporating Lactobacillus salivarius into a healthy lifestyle offers numerous benefits.

With its wide availability in various forms, integrating this probiotic strain into your wellness routine is a simple and practical choice.

FAQs

Where Does Lactobacillus Salivarius Come From?

Lactobacillus salivarius is a naturally occurring bacterium that primarily resides in the gastrointestinal tract of humans and animals. It's also found in certain fermented foods like yogurt and sauerkraut and oral health products such as toothpaste and mouthwash.

Where Can I Get Lactobacillus Salivarius?

Lactobacillus Salivarius can be obtained through dietary supplements available at health food stores, online retailers, and some pharmacies. It's also found in certain fermented foods like yogurt, hard cheese, and sauerkraut. Moreover, some mouthwash and toothpaste products contain this probiotic for oral health benefits.

Is Salivarius A Probiotic?

Lactobacillus Salivarius belongs to the probiotic family, which comprises live bacteria and yeasts beneficial for your well-being, particularly in terms of digestive health. Notably, L. Salivarius is recognized for its capacity to promote a healthy gut and enhance immunity.

Is Salivarius Harmful?

Lactobacillus Salivarius is generally safe for the majority of individuals. This probiotic naturally inhabits the human gastrointestinal tract and can offer various health advantages. Nevertheless, those with weakened immune systems should seek advice from a healthcare expert before initiating any new supplementation plan.

References:

[1]. Yun, X., Shang, Y., & Li, M. (2015). Effect of Lactobacillus salivarius on Th1/Th2 cytokines and the number of spleen CD4+ CD25+ Foxp3+ Treg in asthma Balb/c mouse. International Journal of Clinical and Experimental Pathology, 8(7), 7661–7674. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555661/
[2]. Drago, L., Elena De Vecchi, Gabrieli, A., Roberta De Grandi, & Toscano, M. (2015). Immunomodulatory Effects ofLactobacillus salivariusLS01 andBifidobacterium breveBR03, Alone and in Combination, on Peripheral Blood Mononuclear Cells of Allergic Asthmatics. Allergy, Asthma and Immunology Research, 7(4), 409–409. https://doi.org/10.4168/aair.2015.7.4.409
[3]. Drago, L., Cioffi, L., Giuliano, M., Pane, M., Amoruso, A., Schiavetti, I., Reid, G., Giorgio Ciprandi, & PROPAM Study Group. (2022). The Probiotics in Pediatric Asthma Management (PROPAM) Study in the Primary Care Setting: A Randomized, Controlled, Double-Blind Trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706). Journal of Immunology Research, 2022, 1–7. https://doi.org/10.1155/2022/3837418
[4]. Zhang, M., Fan, X., Fang, B., Zhu, C., Zhu, J., & Ren, F. (2015). Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1, 2-dimethylhydrazine-induced rat model. Journal of Microbiology, 53(6), 398–405. https://doi.org/10.1007/s12275-015-5046-z
[5]. Dong, Y., Zhu, J., Zhang, M., Ge, S., & Zhao, L. (2020). Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition. Applied Microbiology and Biotechnology, 104(17), 7377–7389. https://doi.org/10.1007/s00253-020-10775-w
[6]. Zhang, M., Wang, F., Jiang, L., Rui Hai Liu, Zhang, L., Xin Gen Lei, Li, J., Jiang, J., Guo, H., Fang, B., Zhao, L., & Ren, F. (2013). Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide. Cancer Prevention Research, 6(7), 686–694. https://doi.org/10.1158/1940-6207.capr-12-0427
[7]. EBSCOhost | 117271517 | Effects of Lactobacillus salivarius on oral cancer cell proliferation and apoptosis in vitro. (2016). Ebscohost.com. https://web.s.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=20666845&asa=Y&AN=117271517&h=%2bgvN18Eh1feRO2gYQTQ3J6t6%2bJ3hUJsfkyGEWOlXUf%2bCM1DzjJTdlodD0H9wuzT3Zz4UsfGesHwze4rpPd500g%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d20666845%26asa%3dY%26AN%3d117271517
[8]. De, N., E. (2016). Effects of Lactobacillus Salivarius LS01 (DSM 22775) Treatment on Adult Atopic Dermatitis: A Randomized Placebo-Controlled Study - L. Drago, E. Iemoli, V. Rodighiero, L. Nicola, E. De Vecchi, S. Piconi, 2011. International Journal of Immunopathology and Pharmacology. https://journals.sagepub.com/doi/abs/10.1177/039463201102400421
[9]. Niccoli, A., Artesi, A. L., Candio, F., Ceccarelli, S., Cozzali, R., Ferraro, L., Donatella Fiumana, Mencacci, M., Maurizio Morlupo, P Pazzelli, Rossi, L., Toscano, M., & Drago, L. (2014). Preliminary Results on Clinical Effects of Probiotic Lactobacillus salivarius LS01 in Children Affected by Atopic Dermatitis. Journal of Clinical Gastroenterology, 48(Supplement 1), S34–S36. https://doi.org/10.1097/mcg.0000000000000233
[10]. Wu, K.-C., Li, T.-H., & Peng, H.-J. (2011). Lactobacillus salivarius plus fructo-oligosaccharide is superior to fructo-oligosaccharide alone for treating children with moderate to severe atopic dermatitis: a double-blind, randomized, clinical trial of efficacy and safety. British Journal of Dermatology, 166(1), 129–136. https://doi.org/10.1111/j.1365-2133.2011.10596.x
[11]. Iwamoto, T., Suzuki, N., Tanabe, K., Takeshita, T., & Takao Hirofuji. (2010). Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 110(2), 201–208. https://doi.org/10.1016/j.tripleo.2010.03.032
[12]. Camila Rafaela Mousquer, Álvaro Della Bona, Daiane Cristina Milani, Sídia Maria Callegari-Jacques, Ishikawa, K., Pinto, M., Cassiano Kuchenbecker Rösing, & Fornari, F. (2019). Are Lactobacillus salivarius G60 and inulin more efficacious to treat patients with oral halitosis and tongue coating than the probiotic alone and placebo? A randomized clinical trial. Journal of Periodontology, 91(6), 775–783. https://doi.org/10.1002/jper.19-0089
[13]. Yuji Aiba, Suzuki, N., Kabir, A., Takagi, A., & Koga, Y. (1998). Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model. The American Journal of Gastroenterology. https://doi.org/10.1016/s0002-9270(98)00481-x
[14]. Ryan, K., Daly, P., Yin, L., Hooton, C., & O’Toole, P. W. (2008). Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli. Journal of Antimicrobial Chemotherapy, 61(4), 831–834. https://doi.org/10.1093/jac/dkn040
[15]. Hsieh, P.-C., Tsai, Y., Chen, Y., Teh, S.-F., Ou, C.-M., & V. An-Erl King. (2012). Eradication of Helicobacter pylori Infection by the Probiotic Strains Lactobacillus johnsonii MH‐68 and L. salivarius ssp. salicinius AP‐32. Helicobacter, 17(6), 466–477. https://doi.org/10.1111/j.1523-5378.2012.00992.x
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[19]. Chuang, C., Cheng Chih Tsai, En Shyh Lin, Chin Shiu Huang, Yun Yu Lin, Chuan Ching Lan, & Huang, C. (2016). Heat-Killed Lactobacillus salivarius and Lactobacillus johnsonii Reduce Liver Injury Induced by Alcohol In Vitro and In Vivo. Molecules, 21(11), 1456–1456. https://doi.org/10.3390/molecules21111456
[20]. Yang, L., Bian, X., Wu, W., Longxian Lv, Li, Y., Ye, J., Jiang, X., Wang, Q., Shi, D., Fang, D., Wu, J., Wang, K., Xia, J., Xie, J.-J., & Lu, Y. (2020). Protective effect of Lactobacillus salivarius Li01 on thioacetamide‐induced acute liver injury and hyperammonaemia. Microbial Biotechnology, 13(6), 1860–1876. https://doi.org/10.1111/1751-7915.13629
[21]. Longxian Lv, Hu, X., Qian, G., Zhang, H., Haifeng Lü, Zheng, B., Jiang, L., & Li, L. (2014). Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 improves acute liver injury induced by d-galactosamine in rats. Applied Microbiology and Biotechnology, 98(12), 5619–5632. https://doi.org/10.1007/s00253-014-5638-2
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Author

Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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