Researcher Dr. Mohammad Khaksari Hadad

Overview of Dr. Mohammad Khaksari Hadad

Dr. Mohammad Khaksari Hadad

Dr. Mohammad Khaksari Hadad is a distinguished Professor of Physiology at Kerman University of Medical Sciences (KMU) in Kerman, Iran. His research contributions span various areas, with a focus on traumatic brain injury, neuroprotection, and hormonal effects.

Education and Work

Brain Edema and Neuroprotection:

  • Dr. Khaksari’s research investigates the effects of sex steroid hormones on brain edema, intracranial pressure, and neurological outcomes following traumatic brain injury. His work sheds light on potential therapeutic interventions to mitigate brain damage.

Opium Addiction and Diabetes:

  • He has explored the impact of opium addiction on serum factors in individuals with non-insulin-dependent diabetes mellitus. Understanding these interactions is crucial for managing health conditions in addicted populations.

Hormonal Influence on Inflammatory Responses:

  • Dr. Khaksari’s studies delve into the neuroprotective effects of sex steroid hormones, particularly estradiol, in modulating inflammatory cytokines after brain injury. These findings contribute to our understanding of gender-specific responses to trauma.

Cardioprotective Effects of Calorie Restriction:

  • His research extends beyond brain injury to explore cardioprotective mechanisms. Dr. Khaksari has investigated the impact of calorie restriction on inflammation and apoptosis, emphasizing the role of estrogen receptors and SIRT.

Collaborative Efforts:

  • Dr. Khaksari collaborates with other researchers to explore topics such as the effects of saffron consumption, garlic, and melatonin on health indices. His work contributes to the broader scientific community.


Mohammad Khaksari, Reza Mahmmodi, Nader Shahrokhi, Mohammad Shabani, Siavash Joukar and Mobin Aqapour. (2013). The Effects of Shilajit on Brain Edema, Intracranial Pressure and Neurologic Outcomes following the Traumatic Brain Injury in Rat. Iran J Basic Med Sci. 2013 Jul; 16(7): 858–864

Shahrokhi, N., Khaksari, M., Soltani, Z., Mahmoodi, M., & Nakhaee, N. (2010). Effect of sex steroid hormones on brain edema, intracranial pressure, and neurologic outcomes after traumatic brain injury. Canadian Journal of Physiology and Pharmacology, 88(4), 414-421.

Karam, G. A., Reisi, M., Kaseb, A. A., Khaksari, M., & Mohammadi, A. (2004). Effects of opium addiction on some serum factors in addicts with non-insulin-dependent diabetes mellitus. Addiction Biology, 9(1), 53-58.

Sarkaki, A. R., Khaksari Haddad, M., Soltani, Z., Shahrokhi, N., & Mahmoodi, M. (2013). Time-and dose-dependent neuroprotective effects of sex steroid hormones on inflammatory cytokines after traumatic brain injury. Journal of Neurotrauma, 30(1), 47-54.

Litwak, S. A., Wilson, J. L., Chen, W., Garcia-Rudaz, C., Khaksari, M., Cowley, M. A., & Enriori, P. J. (2014). Estradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice. Endocrinology, 155(11), 4447-4460.

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Journal of Neurology & Neurophysiology

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