7 Best Dihydroberberine Supplements for Metabolism Health 2025

According to research, Dihydroberberine (DHB) helps the body absorb berberine more effectively than standard berberine or even a placebo (Moon et al., 2021). With this superior bioavailability, DHB has become a popular choice for metabolic and cardiovascular support. Leading brands such as Nutricost, Double Wood, and Vinatura Supplements now offer DHB products, but quality and transparency remain key. In this article, we review some of the best options available to help you make an informed decision.

Comparison Table of Dihydroberberine Supplements

How Do We Choose the Best Dihydroberberine Supplements?

Understanding Common Forms of Berberine

• Berberine HCl: A natural extract that is affordable and well-researched. However, it has poor oral bioavailability, often requiring high doses that may cause digestive discomfort.
• Berberine + Bioenhancer: Combined with absorption boosters (such as piperine or milk thistle) to improve bioavailability and add supportive benefits.
• Dihydroberberine (DHB): An active metabolite with higher absorption, less digestive upset, and usually effective at lower doses → making it more tolerable (Moon et al., 2021).
• Berberine Phytosome (Cyclodextrin): Uses phytosome technology for superior absorption and strong effects at low doses. Typically more expensive, and further independent data is still needed (Petrangolini et al., 2021).

Verified Active Form

Dihydroberberine is the active, more bioavailable form of berberine, offering faster absorption and better efficacy. Choose products labeled clearly as “Dihydroberberine” with transparent formulas.

Effective Dosage

With higher absorption, the typical dose is only 100–300 mg/day. Look for supplements that state the active amount per serving, not just capsule weight.

Purity and Quality

Dihydroberberine requires independent third-party testing to ensure purity and safety. Certifications like GMP, NSF, Non-GMO, or Gluten-Free indicate high manufacturing standards.

Trusted Brands & Patents

Prioritize reputable brands in metabolic or cellular health. Patented forms such as Glucovantage® ensure quality, traceability, and scientific backing.

Transparency & Reviews

Choose brands that disclose sourcing, formulas, and certifications. Customer reviews on Amazon, iHerb, and health forums provide insights into real-world results.

Value for Money

Usually more expensive than standard berberine ($0.60–$1.50/serving). Compare cost per serving against dosage, purity, and brand reputation for long-term value.

7 Best Dihydroberberine Supplements:

Black Forest 5X Berberine a Dihydroberberine Supplement 450mg - 30 Servings | $25.16

Black Forest 5X Berberine combines 250mg of Dihydroberberine with a 200mg of Ceylon Cinnamon, creating a unique blend aimed at enhancing metabolic health and supporting weight management.

For those wondering how Dihydroberberine stacks up against regular Berberine in terms of weight loss effectiveness, our detailed comparison in DihydroBerberine Vs Berberine: Which Is Best For Weight Loss? offers valuable insights.

This supplement stands out not only for its potent cinnamon content but also for its user-friendly formulation. The moderate dose of Dihydroberberine makes it a suitable option for individuals looking for a lower, more manageable amount of the compound, possibly to avoid gastrointestinal discomfort sometimes associated with higher doses.

Manufactured in a GMP-certified facility in the USA and third-party tested for quality assurance, the product is Non-GMO, gluten-free, and vegan-friendly.

One notable feature is its black-sealed bottle, which protects the capsules from moisture, light, and oxygen—an uncommon but appreciated detail that helps maintain product integrity without the need for refrigeration.

With over 800 monthly purchases and an Amazon’s Choice badge, Black Forest 5X has built a strong reputation. Around 82% of users gave it high ratings, praising its gentle effect on digestion, improved energy levels, and weight support.

Many customers noted the absence of side effects like stomach upset, which is often a concern with berberine products.

However, it's important to highlight that about 10% of reviewers reported dissatisfaction due to varying individual responses, underlining the importance of personal consideration when choosing supplements.*

Pros

• Vegan, gluten-free, and Non-GMO.
• Made in the USA in a GMP-certified facility and third-party tested.
• Unique black-sealed bottle for enhanced shelf-life without refrigeration.
• High user satisfaction (82%) with positive effects on energy and digestion.
• Gentle on the stomach with fewer reported side effects.

Cons

• Dihydroberberine content is moderate—may not meet needs of those seeking higher doses.
• Around 10% of users experienced less favorable outcomes, suggesting varied individual effectiveness.*

Double Wood Dihydroberberine Supplement 100mg - 60 Servings | $20.65

Double Wood’s Dihydroberberine Supplement is a well-regarded product that has earned the Amazon’s Choice badge and over 1,200 reviews, reflecting strong customer interest with more than 3,000 purchases each month.

Each serving provides 100mg of GlucoVantage® Dihydroberberine, offering a lighter dose than many competitors. With 60 servings per bottle, the supplement is designed to last for two months, making it an appealing choice for those looking for long-term use or beginning their journey with Dihydroberberine.

Manufactured in the USA in a GMP-certified facility and third-party tested for quality and purity, Double Wood ensures transparency and trustworthiness. Users frequently report that the supplement is easy to swallow, well-tolerated, and integrates seamlessly into daily routines.

One user, lponcefb, remarked, “My trainer put me on this and it works great. It does curb my appetite... Great price point, too. The capsules are small and easy to swallow.”*

However, customer opinions vary slightly when it comes to stomach sensitivity and perceived value. While many experience no digestive discomfort, a few have noted mild nausea.*

Similarly, although some consider the price fair given the quality and manufacturing standards, others feel the product could offer more value for money, especially when compared to higher-dosed alternatives.*

Pros

• Contains 100mg GlucoVantage® Dihydroberberine per serving.
• 60 servings per bottle – ideal for two-month use.
• Small capsule size, easy to swallow.
• Manufactured in the USA, GMP-certified, and third-party tested.
• Positive user sentiment reported about appetite control and minimal side effects.
• Amazon’s Choice product with strong user base and credibility.

Cons

• Lower dosage per serving may not suit those seeking higher potency.
• Mixed feedback regarding stomach comfort and overall value for money.*

Vinatura Dihydroberberine Supplement with Ceylon Cinnamon | 500mg - 30 Servings | $23.89

Vinatura GlucoVantage® DihydroBerberine with Ceylon Cinnamon is a premium dietary supplement designed to overcome the limitations of traditional berberine.

Each capsule delivers 250mg of DihydroBerberine (DHB), leveraging its superior bioavailability—up to five times more absorbable than standard berberine. This means users can experience noticeable benefits with a lower dosage and reduced risk of gastrointestinal discomfort.

The formula is further enhanced with 250mg of Ceylon Cinnamon, a natural ingredient known to support healthy blood sugar management.

Together, they create a well-rounded blend that promotes better metabolic health and steady daily energy. In addition to its functional benefits, the supplement is free of soy, tree nuts, wheat, and dairy, making it suitable for individuals with common dietary restrictions.

What sets Vinatura apart is not only its formula but also its commitment to transparency.

The product is manufactured in the USA at an FDA-registered facility, independently third-party tested, and provides full Certificates of Analysis directly on the website.

Notably, Vinatura has earned the Clean Label Project certification, one of the most rigorous standards for purity and safety in the supplement industry—demonstrating its dedication to delivering a trustworthy and clean product.

With a simple daily dosage of one capsule with 240–300ml of water, each bottle provides a 30-day supply. The retail price is $24.89, and with the “Subscribe & Save” option, customers receive a 15% discount, bringing the price down to $21.16 per bottle, a reasonable value for long-term use.

According to reviews on Amazon, most customers report positive results in supporting blood sugar control and maintaining steady energy levels, while also appreciating the capsule’s ease of use and minimal side effects.*

One customer, Brittany Kugler, shared: “I love this product and have tried many other berberine supplements. I haven’t been taking it for long, but I’ll definitely repurchase!”—a sentiment echoed by many other users.*

Overall, Vinatura GlucoVantage® DihydroBerberine with Ceylon Cinnamon stands out as a safe, effective, and transparent choice for those seeking a modern, science-backed supplement to naturally support metabolic health—backed by clear certifications and real customer satisfaction.

Pros

• Gentle digestion with fewer side effects than traditional berberine.*
• Clean Label certified, third-party tested, FDA facility
• Highly rated by users for appetite control and product effectiveness.*
• Easy daily use, allergen-free, affordable with subscription.*
  

Cons

• Some users may prefer a larger supply for long-term use.*

Peak Performance Dihydroberberine Super Berberine Supplement 200mg - 30 Servings | $29.95

Peak Performance Dihydroberberine Super Berberine delivers 200mg of GlucoVantage® Dihydroberberine per serving and has garnered over 1,100 reviews and 1,000 purchases monthly.

Designed with enhanced bioavailability in mind, this supplement leverages studies suggesting that Dihydroberberine can be up to five times more absorbable and twice as long-lasting as traditional berberine.

It's produced in a cGMP-compliant facility and free from common allergens and preservatives, aligning well with vegan, keto, and clean-label lifestyles.

What sets Peak Performance apart is its social impact initiative: for every bottle purchased, the company donates to Vitamin Angels, providing a year’s worth of vitamins to a child at risk of malnutrition.

This 1-for-1 program is a distinguishing feature for socially conscious consumers and reflects the brand’s commitment to global wellness.

The formula is third-party tested and formulated without soy, milk, egg, shellfish, corn, wheat, peanuts, gluten, or artificial preservatives. Many users praise the easy-to-swallow capsules and report improvements in energy and metabolic balance.*

However, it’s important to note that a small but vocal segment of users experienced gastrointestinal reactions.

For example, one reviewer, Adrienne W., shared a distressing experience, stating, “I bought this because Dihydroberberine is supposed to be easier on the stomach. It made me vomit within 20 minutes… I only took a half capsule 4 days ago and I'm still sick.”*

While this is not representative of most reviews, it does underscore the importance of individual sensitivity.*

Pros

• Contains 200mg GlucoVantage® Dihydroberberine per serving.
• Vegan, Non-GMO, allergy-free, keto-friendly.
• Manufactured in a USA-based cGMP facility.
• Third-party tested for purity and safety.
• 1-for-1 donation program with Vitamin Angels supports global child nutrition.
• Easy-to-swallow capsules with generally high user satisfaction.

Cons

• Reports of gastrointestinal side effects in some users.*
• May not be suitable for highly sensitive individuals despite DHB’s general GI-friendly profile.

Nutricost Dihydroberberine Capsules 200mg - 60 Servings | $22.45

Nutricost’s Dihydroberberine Capsules offer a focused and minimalist approach to supplementation, delivering 200mg of GlucoVantage® Dihydroberberine per serving across 60 servings—enough for a full two-month supply.

This product is uniquely formulated with Dihydroberberine as the sole active ingredient, making it an ideal choice for those who are sensitive to or prefer to avoid additional compounds such as cinnamon or black pepper.

The use of GlucoVantage®, a trademarked form of Dihydroberberine, ensures quality and bioavailability, while the lower 200mg dosage per serving caters well to beginners or individuals looking to start with a gentler approach.

Its smaller capsule size has been highlighted by many users as easy to swallow and less likely to cause discomfort, making it a user-friendly option.

Produced in a GMP-compliant facility and independently tested, Nutricost maintains high standards in manufacturing and transparency.

Although it does not include absorption enhancers like black pepper extract—a common addition in other supplements—this can be seen as a benefit for those with allergies or sensitivities. As one reviewer noted, the absence of black pepper made it possible for them to use this product effectively without adverse reactions.*

User feedback has been generally positive. Phillip L Johnson shared, “My wife and I have noticed a difference in our digestion with this product. Better than straight Berberine. Great price as well as high quality.”*

The combination of simplicity, tolerability, and affordability makes Nutricost's product a solid option for those seeking a clean Dihydroberberine supplement.

Pros

• Contains 200mg of GlucoVantage® Dihydroberberine per serving.
• Single-ingredient formula ideal for those avoiding other compounds.
• 60 servings per bottle – a full two-month supply.
• Small capsule size, easy to swallow
• GMP-compliant manufacturing and independently tested.
• No black pepper or cinnamon—good for users with sensitivities.
• Affordable price point with solid user feedback.

Cons

• Lower dose per serving compared to some competitors (e.g., 500mg).
• Lack of added absorption enhancers may be a drawback for some users seeking maximum potency.

Toniq Dihydroberberine Supplement 1000mg - 30 Servings | $16.96

Toniq Dihydroberberine Supplement is a high-demand product with over 1,000 monthly purchases and the Amazon’s Choice badge, reflecting strong consumer trust.

Each serving delivers a 1,000mg total formula that includes 200mg of GlucoVantage® Dihydroberberine, 400mg of Ceylon Cinnamon extract (10:1), and 400mg of Milk Thistle extract (50:1).

This thoughtfully curated blend is designed to provide comprehensive support for metabolic function, cardiovascular health, and liver wellness.

What sets Toniq apart is its unique formulation. While many Dihydroberberine supplements focus on a single active ingredient, Toniq enhances its metabolic support with antioxidant-rich Milk Thistle and Ceylon Cinnamon.

All ingredients are high-potency extracts, carefully sourced and third-party lab tested to ensure quality and purity. The supplement is manufactured in a GMP-certified, state-of-the-art facility in the USA.

Customers appreciate the product’s convenience and overall health benefits. Many find the supplement effective and well-rounded in terms of support for energy, digestion, and metabolic balance.

However, there are mixed opinions on efficacy. While some users note noticeable improvements, others report minimal or no effects, highlighting the individual nature of supplement response.

Pros

• 200mg GlucoVantage® Dihydroberberine per serving.
• Includes 400mg Ceylon Cinnamon and 400mg Milk Thistle for added benefits.
• High-potency extracts (10:1 and 50:1) for enhanced effectiveness.
• Third-party lab tested for quality and purity.
• Manufactured in a GMP-certified facility in the USA.
• Amazon’s Choice product with strong customer support.
• Supports metabolism, liver function, and cardiovascular health.

Cons

• Mixed user feedback regarding overall effectiveness.*
• Multi-ingredient formula may not suit those seeking Dihydroberberine-only options.

Nature's Fusions Dihydroberberine Supplement 200mg 60 Capsules | $27.95

Nature's Fusions Dihydroberberine Supplement offers a clean, streamlined formula featuring 200mg of Dihydroberberine alongside 300mg of organic Ceylon Cinnamon extract per capsule.

With 60 capsules per bottle, the product is positioned as a two-month supply and ranks #35 in the Cinnamon Herbal Supplement category, indicating a strong presence in the metabolic support market.

Manufactured in the USA in a GMP- and FDA-registered food-grade facility, this supplement undergoes third-party lab testing to ensure purity and safety. 

It’s designed with user comfort in mind—customers consistently describe the capsules as small and easy to swallow, a practical advantage for daily use. The inclusion of organic Ceylon Cinnamon also supports overall metabolic function.

In terms of performance, many users report positive effects on weight management and metabolic support*. However, results appear to vary considerably.

Some customers experience noticeable benefits, while others see little to no change, and a few report mild side effects. This wide range of feedback highlights the individual nature of supplement response and reinforces the importance of setting realistic expectations.*

Pros

• 200mg Dihydroberberine and 300mg Organic Ceylon Cinnamon per capsule.
• Third-party tested and produced in a GMP- and FDA-registered facility in the USA.
• Compact, easy-to-swallow capsules.
• Organic ingredients with good bioavailability.
• Ranked #35 in the Cinnamon Herbal Supplement category.
  

Cons

• Mixed feedback on effectiveness—results vary by individual.*
• Some users report minor side effects or no noticeable benefits.*

Conclusion

In conclusion, choosing the best Dihydroberberine supplement comes down to quality, dosage, and trusted sourcing. While research on DHB is still emerging, its superior bioavailability compared to traditional berberine makes it a promising option for metabolic health support.

Always opt for products that offer third-party testing, transparent labeling, and supported ingredients. As with any supplement, consult your healthcare provider to determine if DHB is right for your individual health needs.