5 Best HMB and Vitamin D3 Supplements 2025

There are many studies showing positive results after using HMB and vitamin D3 properly. Typically, John A Rathmacher et al. (2020) demonstrated the effectiveness of improving muscle health when using HMB and vitamin D3 for 117 people over 60 years old, who do not exercise [1].

Or William D Fairfield et al. (2022) studied that HMB can be difficult to fully absorb if the body lacks vitamin D3, so combining the two substances together with a balanced content is extremely important.

The researchers recommended a combination of 3 g of calcium HMB and 2,000 IU of vitamin D3 per day, used for 12 weeks, showing a significant improvement in endurance (Fairfield et al., 2022).

These findings highlight the importance of using HMB and vitamin D3 together. As a result, many products now combine both nutrients. However, variations in ingredients, prices, dosages, and preparation methods make it hard for users to choose the right supplements.

The article below will share quality functional foods containing HMB and vitamin D3 from reputable brands. Let's explore the details in the following article!

Comparison Table of the Best HMB and Vitamin D3 Supplements

How Do We Choose the Best HMB and Vitamin D3 Supplements?

Ingredients & Dosage

Currently, there is no fixed dosage of HMB and vitamin D3 when combined together. However, Healthline indicates that 3 g of HMB, continuously for 3 - 8 weeks can be effective [3].

For vitamin D3, this is a form of vitamin D that the body can produce when exposed to sunlight (such as when sunbathing). Therefore, you only need to supplement vitamin D through food or if not enough, use at least 15 mcg/day (51 - 70 years old) or 20 mcg/day (over 70 years old) up to a maximum of 100 mcg/day [5].

Based on this information, you should look at the product's ingredient list to see if it meets this recommended dosage. This is considered a safe and effective dosage range for most individuals.

In addition, you should check the ingredient list to see if there are any other nutrients besides HMB or vitamin D3. Because, depending on the intended use and intended effect, the manufacturer will consider adding other substances. For example, calcium, phosphorus,...

Form of Supplement

There are many forms of dietary supplements containing HMB and vitamin D3 such as capsules/tablets, powders, solutions, etc.

Each type will have its own advantages and limitations, but currently, most manufacturers choose to design soft capsules or hard tablets. Because this type allows users to carry it out easily without worrying about affecting the quality of the product.

At the same time, each tablet is measured with just enough content according to daily needs, without the user having to calculate much. Also, this is a form that the body can easily metabolize and absorb safely.

Purity & Certifications

In addition to checking the product’s ingredients, users should also consider the purity of each nutrient—specifically, whether the product contains unnecessary additives or fillers. One way to assess purity is by looking for third-party safety and quality certifications, such as NSF or Non-GMO Project Verified.

Consumers should also verify whether the product is manufactured in a facility that complies with FDA standards, as this plays a crucial role in ensuring product safety.

Transparency in the manufacturing process and independent third-party testing of the final product are additional indicators of a trustworthy supplement. Altogether, these factors help build consumer confidence in the supplement’s quality, safety, and reliability.

Intended Use

While all of these products contain both HMB and vitamin D3, the intended use may influence the appropriate dosage and duration. For instance, healthy individuals aiming to enhance muscle mass may require a lower dosage and shorter duration compared to those with compromised bone and joint health.

Additionally, for older adults seeking to improve muscle strength and mobility, HMB supplementation—particularly in the form of calcium HMB—may not be sufficient on its own.

It is often combined with vitamin D3, even in the absence of resistance training (i.e., without lifting weights or engaging in strenuous physical activity) [7]. However, for precise recommendations, it is essential to consult a doctor or nutritionist.

Brand Reputation & Reviews

Another factor that helps you choose the right functional food is based on the reputation of the brand. Usually, brands that have been in operation for a long time can be a good sign that this is a trustworthy brand.

Or if this brand is new but has a lot of positive feedback, it is recommended by many people, even by highly discerning customers. Evaluating both brand heritage and current consumer trust can help guide your decision.

Cost per Serving

The selling price of HMB and vitamin D3 supplements on the market is very diverse, ranging from approximately $0.1/tablet to about $0.25/tablet.

This price range is determined based on the nutrient content in each tablet, production technology, preparation method,... Depending on your personal budget, you can choose the right product.

5 Best HMB and Vitamin D3 Supplements 2025

Nutricost HMB (1500mg) and Vitamin D3 (6000 IU) - 80 servings| $21.97

Review

Nutricost HMB with Vitamin D3 features a well-formulated combination designed to support muscle maintenance and overall bone health, making it particularly beneficial for active individuals and fitness enthusiasts.

Each serving delivers 1500 mg of HMB and 150 mcg (6000 IU) of vitamin D3 to aid muscle recovery, boost energy levels, and maintain skeletal strength.

In particular, the product uses myHMB®. This is a type of HMB that binds to calcium, which is better absorbed by the body than the free form of HMB (HMB-FA) and suitable for most people, even those with poor absorption (Ribeiro et al., 2024).

With 240 capsules per bottle providing up to 120 servings, this supplement delivers both quantity and performance at a competitive price point.

The product comes in a durable, hard plastic bottle with a secure lid, making it both travel-friendly and convenient for daily use.

Customers frequently mention fast shipping and noticeable improvements in workout recovery. Some even reported quick results — one user noted muscle gains within a week, while another mentioned improvements in digestive comfort.*

One verified user - USTech noted that the supplement “helps with muscle recovery and energy levels, especially after intense workouts,” emphasizing how well the HMB and Vitamin D3 work together as a potent combo. Another reviewer, Daniella, praised the clean energy boost without any jittery side effects: “Gives me energy without racing heartbeat... very effective and healthy.”*

Manufactured in a GMP-compliant, FDA-registered facility and verified as Non-GMO and gluten-free, Nutricost ensures quality and transparency. Backed by a 60-day money-back guarantee and positive feedback from over 180 verified buyers, it has earned a solid reputation on the market.

Pros

• Provides 1000mg of HMB and 4000 IU of Vitamin D3 per serving.
• Supports muscle recovery, strength, and bone health.
• Non-GMO, gluten-free, and manufactured in a GMP, FDA-registered facility.
• Comes in a sturdy, travel-friendly container.
• 60-day money-back guarantee for customer satisfaction.
• Using cellulose capsules, no fragrance, no unpleasant odor.

Cons

• Only suitable for use with water, limiting consumption flexibility.
• Some users may find capsule count per serving slightly high (2 capsules).*

Life Extension Wellness Code Muscle Strength & Restore Formula - 30 servings | $24.24

Review

Life Extension’s Wellness Code® Muscle Strength & Restore Formula combines HMB and Vitamin D3 to support muscle health and strength, especially with age.

HMB, derived from leucine, helps maintain muscle mass and promote growth during resistance training, while Vitamin D3 supports bone health and helps muscles function properly.

Although the product is labeled as “unflavored,” it contains mild ingredients like stevia and natural flavors that may give a very subtle taste. Most users describe it as nearly tasteless when mixed with drinks.

Notably, similar to Nutricost HMB, Life Extension also uses MyHMB due to its effectiveness. However, Life Extension contains six times less vitamin D3 than Nutricost (25 mcg [1,000 IU] – 125% DV vs. 150 mcg [6,000 IU] – 750% DV).

On the other hand, Life Extension provides twice the HMB content (3,000 mg vs. 1,500 mg) and a higher amount of calcium (360 mg – 28% DV vs. 210 mg – 16% DV).

This makes it a flexible option for users with different preferences. One satisfied customer named Joe Smith noted, “Being over 50, I feel the difference after putting in the work at the gym. It mixes well with my shakes and doesn’t affect the taste — very convenient.”* This simple formulation meets the needs of users looking for both effectiveness and versatility.

Pros

• Contains research-backed HMB and vitamin D3 to support muscle strength and bone density.
• Manufactured with premium raw ingredients, the supplement is gluten-free, non-GMO, and produced in the USA.
• Easy-mix formula, especially beneficial for those over 50.*
• A Certificate of Analysis is available for transparency, reinforcing the brand’s commitment to quality and scientific integrity.

Cons

• Only available in powder form, which may not appeal to those who prefer capsules.
• No included scoop may make serving measurements less convenient.

Vinatura HMB 3000 mg and Vitamin D - 30 Servings | $29.89

Review

Vinatura HMB 3000 mg and Vitamin D supplement delivers a high-potency blend designed for individuals seeking significant improvements in muscle strength, recovery, and overall physical performance.

Similar to Life Extension, Vinatura also provides 3,000 mg of HMB per serving. However, a key difference is that Vinatura contains up to 390 mg of calcium—much higher than the two products mentioned above—meeting 30% of the Daily Value (DV).

Manufacturing takes place in a U.S. facility that complies with stringent cGMP standards and holds FDA registration.

With third-party testing and Certificates of Analysis provided, Vinatura emphasizes product integrity and transparency.

The combination of HMB and Vitamin D3 has shown particular benefit not only for athletes and active individuals but also for older adults looking to preserve muscle mass and strength, even without an intense training program.

The product is also vegan and free from soy, tree nuts, wheat, and dairy—making it suitable for a variety of dietary needs.

Users consistently report positive outcomes. One customer named Albert remarked, “Recovery time after workouts has improved, and I feel stronger during my lifts. Definitely recommend it if you’re serious about performance.”

Another called Roman shared, “Easy-to-take capsules, no mess... great for serious training or just staying strong.” These reviews underscore the product's effectiveness and convenience.

With a 90-day refund or replacement policy, Vinatura stands confidently behind its supplement, offering both performance and peace of mind.

Pros

• Delivers 3000mg of HMB and 1600 IU of vitamin D3 per serving—a researched dosage.
• Uses myHMB®, a patented and highly regarded HMB form.
• Manufactured in the USA in a cGMP-certified, FDA-registered facility.
• Third-party tested for purity and potency with available Certificates of Analysis.
• Vegan capsules; free of soy, tree nuts, wheat, and dairy.
• Backed by a 90-day refund or replacement policy.
• Easy-to-swallow capsules, no need to mix, saving time.
• Choosing a cellulose capsule shell (vegetable capsule shell) instead of animal gelatin makes the capsule durable, easy to swallow, and friendly to vegetarians.
• The product is stored in high-quality HDPE plastic bottles and inner seals to keep the product inside airtight or leak-proof, limiting transportation risks before reaching consumers.

Cons

• Requires taking four capsules daily, which may be inconvenient for some users.

Prime Powder HMB and Vitamin D3 Supplement 1500mg - 40 Servings | $29.99

Review

Prime Powder’s HMB and Vitamin D3 Supplement offers a balanced formula to support muscle health, strength, and recovery. Each serving contains 1500mg of HMB and 2000 IU of Vitamin D3, a moderate dosage suitable for daily use.

This blend helps maintain lean muscle and physical performance, and the powder format allows easy mixing into beverages...

Although the product does not have a high content like the 3 products mentioned above, it can still provide a moderate amount of HMB & Vitamin D3, and is enough for each day when combined with a scientific diet and lifestyle.

But for those with limited budget, this is an ideal choice when you can supplement HMB & vitamin D3 safely but at a cost-effective cost.

Below are some real feedbacks from customers who have used the product:

Suzy Jones: “The capsules are not too big and don’t leave a nasty aftertaste. The container did not have any broken capsules which is a big plus, so quality control is good. HMB is a well researched supplement and I find it particularly helpful when I’m cutting/trying to lose weight. I feel like it helps preserve muscle mass and speed up recovery. Would definitely buy the Prime Powders version of HMB again.”*

Maine: “I’ve been using this for a few weeks and I have been very active in my workouts between lifting and running and I’ve been taking these daily as recommended.”*

Pros

• Provides 1500mg of HMB per serving to support muscle recovery and strength.
• Powder form allows for flexible and customizable use.
• 40 servings per container offers a relatively good value.
• Unflavored—easily mixes into various beverages or protein shakes.

Cons

• Powder format may be less convenient for users preferring ready-to-use capsules.
• Limited available product and user data to assess long-term effectiveness.

Wild Fuel HMB and Vitamin D3 1000mg - 90 Servings | $39.89

Review

Wild Fuel provides 1000mg of HMB and 375 IU (9 mcg) of Vitamin D3 per serving — a lower but effective dose for beginners or those new to HMB/D3 supplementation.

Designed for those experiencing reduced activity or aging, it promotes strength maintenance in a simple, effective formula. With 90 servings per container, it offers a long-lasting, economical option.

The minimalist ingredient profile—free from unnecessary additives—caters to users seeking a clean supplement. While specific Vitamin D3 dosage and manufacturing details aren't disclosed, the moderate HMB level suits beginners or those preferring a lighter daily dose.

Because the product has a lower content of HMB and vitamin D3 than the above types, it is suitable for those who start using these two nutrients in combination and want to test their body's reaction.

The product is positioned as the product is reasonably priced, but still ensures a reputable source of raw materials; it is odorless and tasteless, so it does not cause discomfort when used.

With benefits like muscle recovery support and enhanced energy, many customers are highly satisfied with Wild Fuel’s HMB and Vitamin D3 supplement. For instance:

• Tyler H. shares, "It kicks in quickly—you can feel the difference. Whether it’s for recovery or a general energy boost, it delivers. Just follow the recommended dose, ideally 30 minutes before a workout with plenty of water."*
• Robert Chow adds, "Fantastic supplement. I’ve used it for six months—easy on the body and essential if you’re active. Highly recommend it, especially with the auto-delivery option for extra savings and convenience."*

Pros

• Contains 1000mg of HMB per serving for daily muscle maintenance.
• Paired with Vitamin D3 to support bone health and muscle strength.
• 90 servings per container offers excellent long-term value.
• Simple formulation may appeal to users looking for minimal ingredients.

Cons

• Specific Vitamin D3 dosage is not disclosed.
• No information available on third-party testing or manufacturing standards.
• May be less effective for advanced users who require higher HMB doses.

Conclusion

Above are the key criteria to consider when choosing dietary supplements containing HMB and vitamin D3, along with top suggestions from reputable brands. Hopefully, this helps you make the safest and most suitable choice for your needs. However, regardless of the brand you choose, always consult your doctor or nutritionist for advice tailored to your health condition. Also, remember to maintain a healthy diet and lifestyle to maximize the supplement's effectiveness.