5 Best GR-1 and RC-14 Probiotic Supplements for Women

Did you know that a woman’s vaginal microbiome can be influenced by everyday factors such as stress, diet, and even the type of underwear worn? Maintaining balance in this delicate ecosystem is essential for long-term comfort and feminine wellness.

In a large-scale study involving 348 women, oral supplementation with Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 over 28 days received overwhelmingly positive feedback-with over 90% of participants reporting noticeable improvements in their personal well-being (Cheng et al., 2022) [5].

With growing interest in the role of probiotics in women’s health, GR-1 and RC-14 have become two of the most researched and trusted strains. In this article, we’ve handpicked five top-rated GR-1 and RC-14 probiotic supplements based on quality, formulation, and customer satisfaction.

Comparison Table Of 5 Best GR-1 and RC-14 Probiotic Supplements for Women

How Do We Choose the Best Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 Supplements?

Brand Reputation

A reputable brand is often associated with strict manufacturing processes, transparent ingredient sourcing, and positive customer feedback.

We prioritize brands that have stood the test of time, possess clear certifications, and are not involved in quality-related controversies. Some of the leading brands in this field include THORNE, RepHresh, Integrative Therapeutics, and Vinatura Supplements.

Ingredients Quality

Probiotics are only effective when they contain the right bacterial strains in sufficient amounts. We evaluate products based on the following criteria:

• Must contain Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 – these are two well-researched probiotic verified strains to support women’s health.
• Sufficient CFU (Colony Forming Units) count – Depending on the product, probiotic counts can range from 1 billion to over 50 billion CFU. Studies suggest that a minimum of 1–10 billion CFU is necessary for benefits.
• Presence of prebiotics or supporting ingredients – Some products include prebiotics (fiber that helps probiotics grow) or additional vitamins and minerals to enhance effectiveness.

Form and Dosage

Probiotics come in various forms, such as capsules, powders, lozenges, or liquid solutions. We prefer capsules for their convenience and ease of use, but it's essential to check whether they have protective coatings to help the probiotics survive stomach acid.

We also consider the recommended dosage, ensuring that the product delivers an effective CFU count with just 1–2 doses per day rather than requiring multiple inconvenient servings.

Manufacturing Standards and Certifications

A trustworthy probiotic supplement must be manufactured under strict safety and quality standards. We assess products based on the following criteria:

• Produced in a cGMP (Current Good Manufacturing Practice) certified facility – a high-level safety standard for dietary supplements.
• Third-party tested – to verify the purity and effectiveness of probiotic strains.
• Free from allergens or harmful additives – Some products are gluten-free, dairy-free, soy-free, and free from artificial flavors, making them suitable for individuals with special dietary needs.

Price and Value for Money

The most expensive product isn’t always the best! We assess the price-to-quality ratio to ensure consumers get their money’s worth. Important factors include:

• Cost per serving – A high-priced product with a potent probiotic count may offer better value than a cheaper but less effective alternative.Number of capsules per bottle – Some products contain 30 capsules (one month’s supply), while others offer 60–90 capsules, providing better long-term savings.

Formula

In addition to GR-1 and RC-14, some products also include other beneficial probiotic strains for gut and vaginal health, such as:

• Lactobacillus crispatus – Helps maintain a healthy vaginal pH balance.
• Lactobacillus gasseri – Supports digestion and reduces bloating.
• Lactobacillus acidophilus – Common in many probiotics, aiding gut microbiome balance.

A well-balanced blend of multiple probiotic strains can enhance effectiveness, but it’s crucial to ensure proper balance to avoid potential side effects.

5 Best Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 Supplements for Women:

Integrative Therapeutics Pro-Flora Women's Probiotic 1 Billion CFUs - 30 Servings | $33.00

Integrative Therapeutics Pro-Flora Women's Probiotic is a highly-rated women’s health supplement on Amazon, with a 4.1/5-star rating from 710 reviews and an "Amazon’s Choice" label, affirming its quality and reliability.

In terms of ingredients, Pro-Flora Women's Probiotic is free from salt, soy, artificial flavors, and preservatives. It is also gluten-free, making it suitable for a wide range of users. Each bottle contains 30 capsules, providing a one-month supply for easy integration into a personal wellness routine.

Cole shares that this product has been a game-changer for her feminine wellness. She had previously struggled to find a long-term solution for feeling consistently balanced and tried several approaches with limited results.*

After taking this product daily for two years, she has experienced noticeable improvements in comfort and stability. On the rare occasions she feels off, taking two capsules for a few days helps her feel back on track.*

However, some customers had negative experiences with the product. Leah (1/5 stars) complained that the bottle had no safety seal, the cap was difficult to open, and even injured her while trying.*

Pros

• Supports vaginal & urinary health – Encourages a healthy balance of beneficial bacteria and contributes to long-term intimate wellness.
• Effectiveness – Many users report feeling more balanced and experiencing positive changes in comfort and overall vaginal wellness.*
• No refrigeration needed – Convenient for travel and storage.
• Improves pH balance & body odor – Some users feel fresher, experience less odor, and have better overall balance.

Cons

• Inconsistent quality – Some capsules have unusual colors, raising concerns about product consistency.
• Difficult to use – The bottle cap is hard to open and may cause damage.
• Ingredient concerns – Contains maltodextrin, which may negatively affect digestion.
• Possible side effects – Some users report stomach pain, frequent urination, and discomfort.*

Jarrow Formulas Fem-Dophilus® - 5 Billion CFU - 30 Servings | $32.49

Jarrow Formulas Fem-Dophilus is a probiotic supplement specifically designed for women, with a 4.5/5-star rating from 394 reviews.

It supports vaginal and urinary microbiome balance with scientifically studied Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14, backed by over 30 years of research and more than 20 scientific studies.

Each serving delivers 5 billion CFU, ensuring that live bacteria survive stomach acid to be effective. Recognized by ConsumerLab as the #1 probiotic brand for customer satisfaction, Fem-Dophilus is also suitable for vegetarians and vegans.

Locon rated it 5/5 stars, sharing that Fem-Dophilus has been the most effective addition to her routine for supporting balance after taking antibiotics. She noted feeling noticeably better overnight after using it both orally and vaginally. Now, with just one capsule daily, she feels confident in maintaining a healthy and balanced feminine environment.*

With 77% of users giving 5-star reviews, the product is praised for its ability to support vaginal and urinary health. Many users report quick improvements in fungal overgrowth and bacterial imbalance. However, 6% of reviewers gave 1 star, mostly due to improper shipping conditions that may have compromised the product’s effectiveness. Some users saw no improvement and opted for alternatives like vitamin C.*

Pros

• Highly effective – Supports relief from fungal overgrowth, vaginal imbalance, and quickly helps restore pH balance.
• Natural & safe – Does not cause antibiotic-like side effects.
• Easy to use – Oral supplement, no need for topical treatments or suppositories.
• Digestive support – Beneficial for gut health and immune function.

Cons

• Not effective for everyone – Some users did not experience the expected results.
• Poor shipping conditions – Lack of refrigeration during transport may reduce effectiveness.
• Allergy risk – May contain casein, making it unsuitable for those with dairy allergies.

Vinatura Lactobacillus (38B CFU Probiotics) 30 servings | $26.89

VINATURA Probiotics is a comprehensive wellness supplement designed to support women’s health, providing 38 billion CFU from six well-researched probiotic strains: Lactobacillus rhamnosus, L. reuteri, L. gasseri, L. plantarum, L. crispatus, and L. acidophilus.

These strains are recognized for their role in supporting microbiome balance, digestive function, and overall well-being.

The product is manufactured in the United States in a cGMP-certified facility and undergoes third-party testing. A Certificate of Analysis (CoA) is available to verify safety and quality, confirming that the product is free from unnecessary harmful bacteria and heavy metals. It is also free from soy, wheat, and dairy, making it suitable for a wide range of users.

Customer reviews highlight various benefits. Geeta Lee describes it as an essential part of her daily routine for women’s health. Another user, Keep Shopping, appreciates the 38 billion CFU formulation from six strains and notes the convenience of not requiring refrigeration.*

In addition to product quality, VINATURA is recognized for its strong customer service. The company offers a 90-day satisfaction guarantee with no need to return the product for a refund. Customers may also exchange unopened items within 90 days or request a replacement within 14 days if a manufacturing defect is found.

One notable example is from a reviewer, Kat J, who experienced an unexpected personal reaction. After posting a neutral review, she was contacted by VINATURA’s customer support team with a prompt apology and a full refund offer—without any request to revise or remove her feedback. She commented:

"It’s rare to see this level of professionalism. I truly appreciated it and updated my rating accordingly."*

With an average rating of 4.6 out of 5 stars, 80% five-star reviews, and 89% overall positive feedback, VINATURA Probiotics is viewed as a trusted choice for women seeking daily support for microbiome health and personal comfort.

Pros

• Highly effective – Many customers experience improvements in gut health and microbiome balance.
• Top-quality production – Manufactured in the USA, GMP-certified, and third-party tested.
• Easy to take – Only one capsule per day, with no unpleasant odor.
• No refrigeration needed – Convenient for travel and long-term storage.
• Supports women’s health – Users report improvements in digestion and vaginal health.

Cons

• The diverse blend of probiotic strains may not be ideal for individuals specifically seeking only Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14.

THORNE Women's Daily Probiotic 10 Billion CFUs - 30 Servings | $37

Thorne is trusted by champions, a partner of the U.S. National Team, and the #1 scientifically recommended brand by healthcare professionals.

THORNE Women's Daily Probiotic is rated 4.6/5 stars from 209 global reviews, with 82% of users giving it 5 stars. Customers praise its noticeable effects within a week, helping with digestion, reducing bloating, and alleviating digestive discomfort. The formula contains high-quality probiotics, specifically designed for women's health.

Users consider THORNE Women's Daily Probiotic the best probiotic for women they have ever used*. Within 3-4 days, unpleasant odors disappeared. The product is of high quality and contains Lactobacillus reuteri, which is beneficial for health.

Pros

• High-quality product with no unpleasant smell or taste.
• Fast-acting, improving gut health within a week.
• Easy to digest, does not cause discomfort or strong reactions.
• Supports digestion.
• Specially formulated for women's health, promoting microbiome balance.

Cons

• May cause stomach pain, bloating, or digestive discomfort in some cases.*
• Some customers report side effects like brain fog.*
• Customer service and return policy could be better, with some users not receiving responses.

RepHresh Pro-B Probiotic Supplement for Women 5 Billion CFUs - 30 Servings | $23.19

As one of the most trusted brands in women’s health, RepHresh Pro-B is highly rated not only by consumers but also by medical professionals.

RepHresh Pro-B Probiotic Supplement for Women is a trusted option formulated to support the natural balance of bacteria and yeast in the vaginal microbiome. By promoting a stable environment, it helps maintain overall feminine wellness and comfort.

The product has received a 4.6/5 star rating from 1,172 global reviews, with 84% of users giving it 5 stars. Many customers report that this probiotic is effective, with some noticing results within just a week of use.*

Users appreciate its ability to support a consistent pH environment and overall comfort, considering it a valuable addition to their routine. The small capsule size is also praised for being easy to swallow.*

However, a small number of users report mild side effects such as stomach discomfort.*

Pros

• Fast results – Many customers see effects within a week.
• Supports pH balance – Helps promote overall vaginal wellness and daily comfort.
• Small, easy-to-swallow capsules – Convenient for daily use.
• Endorsed by many gynecologists.

Cons

• Not effective for everyone – Some people saw no significant changes even after finishing a bottle.*
• May cause adverse reactions – Some users reported itching, pH disruption, and even fungal overgrowth after use.*

Conclusion

Supplementing with Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 through high-quality probiotic products may help support vaginal health, maintain microbial balance, and helps with fungal overgrowth.

However, the effectiveness of probiotics depends on diet, lifestyle, and consistent use. When choosing a product, consider reputable brands, additional ingredients, and probiotic count to maximize health benefits. If you experience any vaginal health concerns, it is advisable to consult a doctor before using probiotics.