Best Nattokinase Supplements

7 Best Nattokinase Supplements for Cardiovascular Health

Nattokinase is increasingly being used widely for its effects on normalizing blood, improving circulation, and improving cardiovascular health.

Below are the 7 best Nattokinase Supplements for cardiovascular health that you can refer to:

  • Vinatura Supplements Lumbrokinase Nattokinase Serrapeptase
  • Doctor’s Best Nattokinase 2000FU
  • Double Wood Supplements Nattokinase Supplement 4000FU
  • Nutricost Nattokinase 2000FU
  • Solaray Deep Vein Support
  • Now Nattokinase
  • Pure Encapsulations NSK-SD Dietary Supplement

Vinatura Supplements Lumbrokinase Nattokinase Serrapeptase

Vinatura Supplements Lumbrokinase Nattokinase Serrapeptase


Vinatura's Lumbrokinase Nattokinase Serrapeptase supplement supports cardiovascular health, reduces oxidative stress, and maintains a healthy blood flow.

It represents a scientific blend of protein-digesting enzymes and other blood-beneficial supplements. It offers circulatory system benefits and reduces stress and fatigue during the day while improving sleep quality at night.

The formula includes ingredients like Nattokinase, a traditional Japanese food supplement without vitamin K, blended with Serrapeptase (an anti-inflammatory, anti-infection agent) and Lumbrokinase enzyme units (good for the heart and circulation) sourced from natural sources, known for their blood circulation benefits. Packaged in a single capsule for easy use and cost savings.

The highlight is that with just one Vinatura Supplements Lumbrokinase Nattokinase Serrapeptase capsule, users can get the full daily dosage needed, including 2000 F.U. of Nattokinase, beetroot powder for lowering blood pressure, Rutin for circulation, 800,000 units of Lumbrokinase, and triple the amount of Serrapeptase compared to other products.

Some individuals may experience high blood pressure, constipation, or breathing difficulties at high doses or if the body cannot adapt to the ingredients.

  • Dosage: 60 capsules per serving. Use 1 capsule per day, can be combined with more capsules if necessary, not exceeding 6 capsules a day, and can be used with or without food.
  • Highlight Benefits: Maintains cardiovascular health, supports circulation, enhances immune function, reduces oxidative stress, and alleviates stress.
  • Form: Capsules
  • Main Ingredients: Lumbrokinase, Nattokinase, Serrapeptase, Beetroot, Rutin.


  • A blend of diverse protein-digesting enzymes beneficial for heart health, like Serrapeptase and 2000 F.U. Nattokinase.
  • Features many units of Lumbrokinase, supporting smooth flow and addressing adrenal fatigue.
  • Encapsulated in an easy-to-consume form, offering a more affordable option than purchasing separately.
  • Tested and manufactured in the USA, ensuring purity and quality.
  • Certificate of Analysis (COA) issued.


  • May cause side effects if used at high doses or not suited to the body.

Doctor’s Best Nattokinase 2000FU

Doctor’s Best Nattokinase 2000FU


Doctor's Best Heart Health and Circulation Support dietary supplement is extracted from fermented soybeans, using traditional Japanese "Natto.”

This product does not contain Vitamin K2, is non-GMO, and is fermented with Bacillus subtilis bacteria. It helps maintain normal fibrinogen levels in the blood, supports circulation, and regulates necessary blood flow throughout the body.

  • Dosage: 90 vegan capsules per serving. Take one capsule daily between meals. Remember to follow the nutritionist's instructions.
  • Highlight Benefits: Supports blood circulation, maintains normal blood levels, and balances fibrinogen levels in the blood.
  • Form: Capsules
  • Main Ingredients: Nattokinase, modified cellulose, maltodextrin, magnesium stearate.


  • Supplements Nattokinase, a protein-digesting enzyme beneficial for the circulatory system.
  • Supported by research and made with pure ingredients.
  • Non-GMO, gluten-free, suitable for vegetarians.


  • Overdosing may lead to side effects.
  • May irritate if not suited to the body.
  • Takes time to notice benefits.

Double Wood Supplements Nattokinase Supplement 4000FU

Double Wood Supplements Nattokinase Supplement 4000FU


Double Wood's Nattokinase Supplement, derived from Japanese Natto, provides enzymes that support cardiovascular and circulatory health.

The capsule contains nutritious ingredients like Nattokinase 4000 FU, Hypromellose, Rice Flour, Microcrystalline Cellulose, and Silica, which are noted for their palatable taste and ease of swallowing.

Double Wood Supplements Nattokinase Supplement is great for cardiovascular health, stabilizes blood flow, and maintains the circulatory system's health.

  • Dosage: 120 vegan capsules per serving. Take one capsule daily, with or without food.
  • Highlight Benefits: Enhances cardiovascular health and promotes a healthy circulatory system.
  • Form: Capsules
  • Main Ingredients: Nattokinase, Hypromellose, Rice Flour, Microcrystalline Cellulose và Silica


  • Supplements Nattokinase are beneficial for the circulatory system, easing blood flow.
  • Manufactured and tested in the USA.
  • Non-GMO and gluten-free.


  • Not suitable for those with soy allergies.
  • Nattokinase enzymes may stimulate acid production in the stomach, causing some mild stomach pain or discomfort.
  • May cause heartburn, muscle cramps, constipation.
  • The pills do not have the distinctive smell of Natto.

Nutricost Nattokinase 2000FU

Nutricost Nattokinase 2000FU


This product contains Nattokinase 2000 F.U. to promote healthy blood flow and circulation. Nutricost Nattokinase helps direct calcium to the bones instead of forming plaques around the heart.

  • Dosage: 120 vegan capsules per serving. Take one capsule daily with 8-12 oz of water, as directed by a healthcare professional.
  • Highlight Benefits: Promotes blood flow, facilitating a smoother circulatory process.
  • Form: Capsules
  • Main Ingredients: Nattokinase, Rice flour, Hypromellose cellulose


  • Non-GMO, gluten-free. Vegan-friendly.
  • Small, flavorless capsules, easy to swallow.
  • Third-party tested with ISO-certified laboratories.


  • The product may cause side effects.
  • Not suitable for pregnant and breastfeeding women, individuals on medication, or with underlying health conditions.

Solaray Deep Vein Support

Solaray Deep Vein Support


Solaray Deep Vein Support features a formula with essential elements such as Nattokinase, yellow sweet clover, bromelain, and other ingredients designed to improve the circulatory system, maintain healthy blood vessels, and offer overall health benefits.

It is highly regarded for its effectiveness in enhancing vein strength, reducing the appearance of veins on legs, and promoting good blood circulation.

  • Dosage: 60 vegetarian capsules per serving, with 2 capsules daily with water or a meal, following the directions provided.
  • Highlight Benefits: Improved circulation, maintained health of blood vessels, and supported blood flow.
  • Form: Capsules
  • Main Ingredients: Nattokinase, Hesperidin, Bromelain.


  • Free of artificial colors, preservatives, and flavorings.
  • Tested and tried to ensure purity and safety.
  • The plant-based formula is suitable for vegetarians.


  • May not be effective for some individuals.
  • Can cause flatulence.
  • Be aware of the ingredients to avoid allergies or sensitivities.

Now Nattokinase

Solaray Deep Vein Support


Now, Nattokinase is a dietary supplement extracted from non-GMO soybeans, containing Nattokinase (an enzyme derived from fermented Japanese soy food) that promotes heart health and circulatory system through balancing and maintaining normal blood flow.

The product contains 2000FU per 100 mg serving and has received high customer satisfaction for its health benefits.

  • Dosage: 60 vegetarian capsules per serving. Daily value not established.
  • Highlight Benefits: Improves circulation, prevents blood clots, enhances blood flow speed, and stimulates nutrient transportation to muscle cells.
  • Form: Capsules
  • Main Ingredients: Nattokinase, Microcrystalline Cellulose, Hypromellose, Stearic Acid and Silicon Dioxide.


  • Manufactured and quality tested in the USA.
  • It is free from wheat, gluten, milk, eggs, fish, tree nuts, and sesame, making it allergy-free from these ingredients.


  • Natural color variation may occur.
  • Not suitable for pregnant women, nursing mothers, and those on blood thinners or with clotting or bleeding disorders.
  • Contains soy, which may cause allergic reactions in sensitive individuals.

Pure Encapsulations NSK-SD Dietary Supplement

Pure Encapsulations NSK-SD Dietary Supplement


Each Pure Encapsulations capsule packs pure NSK-SD, providing 100 mg Nattokinase to support blood circulation and vascular health. NSK-SD packaging technology maximizes fibrinolytic activity.

  • Dosage: 60 capsules per serving. Take one capsule twice daily, 12 hours apart, with or between meals.
  • Highlight Benefits: Improves circulation, prevents blood clots, enhances blood flow speed, and stimulates nutrient transportation to muscle cells.
  • Form: Capsules
  • Main Ingredients: NSK-SD Nattokinase, hypoallergenic plant fiber, vegetarian capsule and ascorbyl palmitate.


  • The small capsule is easy to swallow.
  • Packed with pure ingredients, free from common allergens, artificial components, and GMOs.
  • The product's sustainability has been certified.


  • May cause insomnia in some users.
  • Not suitable for individuals allergic to soy.
  • Not for use by pregnant or nursing women.

Buying Guide for Choosing the Best Nattokinase Supplements for Cardiovascular Health

To select a quality Nattokinase product that fits your health needs and budget, here are some criteria to consider:


Each product and supplier offers Nattokinase dietary supplements at different prices, usually from $19.00 to $30.00.

Some products may be more expensive (78,60$ - 146,20$) due to certifications and quality testing, even if they have the same nutritional content as others.

Additional Ingredients

The additional ingredients in Nattokinase Supplements include Lumbrokinase, Serrapeptase, BeetRoot, Rutin, modified cellulose, maltodextrin, magnesium stearate, Stearic Acid, and Silicon Dioxide.

It is important to consider the accompanying ingredients alongside Nattokinase in Nattokinase Supplements to prevent allergies and side effects. If necessary, do not forget to consult a doctor.

Ratio of Nattokinase

Choose a product that offers at least 2000FU of Nattokinase per serving. This necessary nutrient amount should be listed on the product packaging, so close attention should be paid to ensure effective consumption.

Brand Reputation

Brand reputation is also an important factor. Look for a company or brand with a good track record in functional food production or has received many prestigious awards and high ratings from previous customers.

Check FDA certification (U.S. Food and Drug Administration) and food safety certifications (GMP, BRC, or ISO 22000...).

Additionally, you can refer to Amazon Choice's recognized brands. Additional expert opinions can be sought on reputable brands that offer Nattokinase supplements.

Review & Rating

Consider the evaluations and opinions of those who have already used the product to make a suitable choice for your needs. Connecting with people who share your health condition is best to get the most accurate answers.


Each body adapts and prefers different forms of medication. Consider your needs, lifestyle, and habits to choose between capsules, powders, or liquids. Capsules are recommended for ease of consumption, portability, and preservation.

Third-Party Testing

The assessment and testing by a third party are crucial for a quality product. Prioritize products that are well-reviewed and certified by reputable third parties to get an objective view of each product.

Health Goals

The last but most important factor is carefully considering your health improvement goals. Consult with specialists to find the most suitable and effective combination of ingredients.


What Are The Risks Involved With Taking Nattokinase Supplements?

Similar to other supplements, Nattokinase can cause potential side effects such as skin allergies, respiratory symptoms, and digestive issues. Those on blood thinners or with bleeding disorders should consult a doctor before use.

How Can I Assess The Reliability Of Nattokinase Supplement Reviews?

To assess the reliability of Nattokinase supplements, when considering customer reviews through online sales pages or getting advice directly from them, you should compare various opinions to obtain the most comprehensive overview. Ideally, seeking advice from a physician or healthcare professional is the best way to get an accurate assessment.

What Potential Health Improvements Can I Expect From Nattokinase?

Nattokinase, extracted from the Japanese soy food Natto, has been studied for its effects on cardiovascular health, and blood flow.

Do Nattokinase Supplements Contribute To Better Heart Health?

Nattokinase dietary supplements are highly regarded for enhancing heart health, maintaining normal blood circulation, and reducing oxidative stress. However, more studies are needed to prove these benefits conclusively.

Should I Choose A Nattokinase Supplement With Or Without Vitamin K2, And Why?

For those lacking Vitamin K2 and seeking to improve heart health, Nattokinase with Vitamin K2 is appropriate. However, individuals with bleeding disorders or on blood thinners should consult with healthcare professionals before adding Vitamin K2.

For The Best Results, When Should I Take Nattokinase Supplements Each Day?

The efficacy of Nattokinase supplements varies with food and product type. Each product provides dosage information and directions for usage on its packaging. However, the best time to use Nattokinase is after dinner, before sleep. Natto's natural smell and taste may make it difficult for you to consume before bedtime, but do not worry; Nattokinase Supplements will make it easier for you to take.

Can You Safely Combine Nattokinase Supplements With Other Medications You Are Taking?

Nattokinase supplements should be avoided with blood thinners (Warfarin), antiplatelet drugs (Aspirin, Clopidogrel), and certain supplements (Vitamin E, Fish oil) due to their blood-thinning mechanism.

What's The Proper Dosage For Nattokinase Supplements?

Although standard dosage evidence is limited, experts recommend a daily dosage of 2000FU-4000FU, equivalent to 100mg-200mg. However, consult a doctor to ensure effective and safe consumption.

Is It Safe To Take Nattokinase Supplements While Pregnant Or Breastfeeding?

The safety of Nattokinase supplements for pregnant or nursing women has not been proven. Consult a doctor or healthcare professional for safety.

How Long Should I Take Nattokinase?

Research suggests Nattokinase supplements should be consumed for a maximum of 3 years [1] to ensure safety and effectiveness in enhancing heart health and managing high blood pressure.

How Long Does It Take Nattokinase To Effects?

Nattokinase supplements typically show effects within 2 months of consistent use, alongside a healthy diet and regular exercise [2].


Nattokinase supplements aid in improving heart health and blood circulation and are widely used by many consumers. The information above can help you find the best product for your needs.


[1] “Nattokinase: Uses, Side Effects, Interactions, Dosage, and Warning.”,
[2] Kurosawa, Yuko, et al. “A Single-Dose of Oral Nattokinase Potentiates Thrombolysis and Anti-Coagulation Profiles.” Scientific Reports, vol. 5, no. 1, 25 June 2015, p. 11601,,
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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