How Much Milk Thistle Per Day On Cycle

How Much Milk Thistle Per Day On Cycle?

Milk thistle is a popular choice for protecting the liver during steroid cycles. However, its usage requires proper dosage and timing adherence to ensure adequate liver protection and minimize unwanted side effects. Typically, daily milk thistle dosage during a cycle ranges from 30mg to 40mg daily for four weeks to maintain the stability and effectiveness of liver protection. Refer to the article below for more details on safe and effective milk thistle use.

Before exploring further, please read the disclaimer located at the end of this webpage.

Key Takeaways

  • Currently, no studies prove harmful effects when using milk thistle alongside steroids.
  • It's advisable to use milk thistle both during and after steroid cycles with a dosage of 30mg to 40mg daily for four weeks for liver protection and recovery.
  • Ensure correct dosage, consult a doctor before use, and maintain consistency for effectiveness.

Should You Take Milk Thistle While On Steroids?

milk thistle can be used during steroid use

Currently, no studies indicate harm when using milk thistle with steroids. Some users find milk thistle beneficial for steroid users with excellent results.

As known, steroids (corticosteroids) are anti-inflammatory drugs that treat conditions like arthritis, asthma, rashes, and immune-related diseases. However, improper steroid use can harm the liver, causing elevated serum enzymes, acute liver syndrome, liver blood vessel damage, and tumor formation [1].

In contrast, milk thistle benefits the liver due to its anti-inflammatory, antimicrobial properties. Studies also show its potential protective effects against gene damage, enhancing liver cell protein synthesis, reducing tumor-promoting activities, stabilizing mast cells, iron chelation, and slowing calcium metabolism [2].

In summary, milk thistle can be used during steroid use, as using multiple steroids can adversely affect the liver. Milk thistle protects the liver from toxins and steroid-containing drugs, promoting new liver cell development and enhancing overall liver health.

How Much Milk Thistle To Take On Cycle?

It should be noted that no study or source provides accurate milk thistle dosages necessary for the cycle.

Milk thistle can be used continuously for up to 41 months at a dosage of 420 mg/day split into daily doses by a 2013 study by Milić [3] for silymarin's antioxidant and UV protection effects.

In addition, milk thistle can be used in an 8-week cycle with a dosage of 600 mg/day (divided into three doses/day) in a 2010 study by Sayyah [4] for adults with obsessive-compulsive disorder.

When To Take Milk Thistle On Cycle: During Or After Cycle?

milk thistle can be used during and after the cycle

As mentioned above, milk thistle can be used concurrently with anabolic-androgenic steroid cycles (AAS). However, should it be used during or after the cycle? The fact is both.

Milk thistle can be used in conjunction with steroids to minimize liver damage and support liver function during steroid use. This may help reduce the development of liver issues such as hepatitis and enzyme increases caused by steroids.

After stopping steroid use, supplementing milk thistle helps support liver recovery. This is a stage that requires special liver care as the liver may have been damaged due to steroid use. Milk thistle may help regenerate liver cells and minimize liver damage after using steroids.

How to Take Milk Thistle On Cycle

Milk thistle is beneficial for the liver in high-dose steroid users; however, not all uses are practical. To maximize its benefits, consider the following use:

  • Dosage: 30mg to 40mg daily for four weeks
  • Usage: Use with food to improve absorption and reduce discomfort in the stomach
  • Note: Choose quality products from a reputable source

What Should You Be Aware of When Taking Milk Thistles For Steroids?

What Should You Be Aware of When Taking Milk Thistles For Steroids

The emphasis on all types of supplements, in general, and milk thistle, in particular, is the right dose. Ensure the correct daily dosage is used and persist in using it to see results.

Milk thistle can cause gastrointestinal problems (diarrhea, constipation, nausea, stomach discomfort), headaches, and itching rashes on the skin. Milk thistle should be used with caution in patients with diabetes because it affects estrogen levels; in addition, breast cancer, cervix, and allergies should be considered [5].

In addition, using milk thistle while using steroids should be under the direction of a specialist. The physician will evaluate your health status and give guidelines on dosage and appropriate use time. Always adhere to medical advice and instructions to ensure safe and effective treatment.


In conclusion, milk thistle is an effective and safe method to supplement during steroid use. Along with adherence to dosage and the combination of milk thistle and steroids, to ensure the appropriateness and effectiveness of the treatment, consult a physician or specialist for specific and detailed advice.


  • [1] “Androgenic Steroids.” PubMed, National Institute of Diabetes and Digestive and Kidney Diseases, 2012,
  • [2] “Milk Thistle (Silybum Marianum) for the Therapy of Liver Disease.” The American Journal of Gastroenterology, vol. 93, no. 2, 2021, pp. 139–143,,
  • [3] Milić, Natasa, et al. “New Therapeutic Potentials of Milk Thistle (Silybum Marianum).” Natural Product Communications, vol. 8, no. 12, 1 Dec. 2013, pp. 1801–1810, Accessed 24 June 2024.
  • [4] Sayyah, Mehdi, et al. “Comparison of Silybum Marianum (L.) Gaertn. With Fluoxetine in the Treatment of Obsessive−Compulsive Disorder.” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 34, no. 2, 17 Mar. 2010, pp. 362–365,, Accessed 1 June 2023.
  • [5] “Milk Thistle.” Mayo Clinic, 2017,
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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