Is NMN Better Than NMNH As A NAD+ Enhancer?
Is NMN better than NMNH? This is probably what those who are interested in cell health care and longevity are interested in. These are two compounds that are widely studied and used in the healthcare community.
Although they both have similar effects, these two compounds still have certain differences. In the following article, we will learn about the differences between these two compounds to see if NMN is better than NMNH.
Before exploring further, please read the disclaimer located at the end of this webpage.
Key Takeaways
- NMN and NMNH are both precursors that help increase NAD+, a molecule that plays an important role in regenerating energy for cells and prolonging life.
- NMNH allows for a faster and more effective increase in NAD+ than NMN, thanks to its direct metabolism without the need for supplementation.
- Depending on the purpose of use (anti-aging or rapid energy recovery), you can choose NMN or NMNH accordingly.
What Is the Difference Between NMN and NMNH?
About NMN
Nicotinamide Mononucleotide (NMN) is a nucleotide containing a nicotinamide group linked to a ribose and phosphate group. It is an important NAD+ precursor in the body and plays a core role in the production of cellular energy.
When supplemented with NMN, the body converts this compound into NAD+ through a series of enzymatic reactions, thereby helping the body increase cellular energy, restore DNA function and improve overall cellular health [1].
About NMNH
NMNH (Nicotinamide Mononucleotide Hydride) is an improved variant of NMN with an additional hydrogen atom, making this variant a more efficient energy carrier. Thanks to this property, NMNH can convert into NAD+ directly and faster than NMN without going through intermediate steps.
With the ability to convert directly into NAD+ without going through metabolic enzyme steps, NMNH helps the body regenerate energy quickly, increasing the ability to resist the effects of free radicals and oxidative stress more strongly [2].
NMN Vs NMN Comparison Table
To have a more general and objective view of the structure, metabolism,... of the two compounds NMN vs NMNH, please follow our comparison table below:
Characteristic |
NMN |
NMNH |
Chemical Structure |
Nicotinamide Mononucleotide |
Nicotinamide Mononucleotide Hydride |
Conversion Process |
Requires an intermediate conversion step |
Converts directly to NAD+ |
NAD+ Boosting Ability |
Gradual and stable increase |
Rapid increase with immediate effects |
Strength |
Suitable for long-term health enhancement and cell health improvement |
Quick energy recovery in the short term |
Is NMN Better Than NMNH?
If your goal is to increase NAD+ for long-term health improvement, then NMN is better for your body than NMNH. As we mentioned above, NMN has the ability to increase NAD+ through enzymatic reactions, and this helps your body's energy regeneration take place slowly and steadily.
Meanwhile, an animal model study has shown that NMNH helps to dramatically increase NAD+ levels in cells up to 10 times. At the same time, this study also noted the ability to increase NAD+ after supplementing NMNH extremely quickly within just 15 minutes [3].
However, NMNH is still a relatively new compound, and the research just mentioned was conducted on mammalian and mouse models. Therefore, more research on this compound is needed to confirm the effectiveness and ability of NMNH.
As a NAD+ Enhancer: Choose NMN Or NMNH?
As an NAD+ booster, whether NMN is better than NMNH depends on individual needs and health status. However, it is undeniable that NMNH seems to have stronger and broader effects on the body than NMN [3].
NMNH is noted for its ability to affect many tissues, and maintaining NAD+ enhancement will bring more comprehensive and obvious health benefits such as improved metabolism, restoring DNA function, and better energy regeneration.
In addition, the FDA has decided to ban NMN as a dietary supplement, and this compound is being studied as a new drug. Meanwhile, NMNH is also a factor that you need to consider carefully before deciding to choose NMN or NMN supplements.
Because of these factors, you can carefully consider which compound to use to increase NAD+. Remember, no matter which product you choose, your health condition and suitability to your body must always be the top priorities.
NMNH And NMN: Things To Note
Although these are both compounds that are considered safe to use, there are still some undesirable side effects, some symptoms that may occur, such as digestive disorders, nausea, diarrhea, hypoglycemia due to the use of NMN, or high blood pressure, and nervous system stimulation caused by NMNH.
In addition, some contraindications are recommended for pregnant and lactating women; NMNH is contraindicated for people with a history of cardiovascular disease and NMN for people who are using diabetes medication.
However, there is currently not enough research on the effects of these two compounds on contraindicated subjects, nor have there been any recorded adverse cases of the effects of these two substances. Therefore, to ensure your safety, please consult a medical expert before using.
Best Way To Supplement NMN And NMNH
Both NMN and NMNH are currently prepared in capsule, powder and liquid form, which can be easily used and stored. To achieve optimal results, you should prioritize using products from reputable suppliers.
Make sure you have carefully checked the information on ingredients, content, dosage, place of manufacture, certification labels, expiration date, and usage before purchasing the product.
This is the basic information that must be on the packaging of each dietary supplement product. This information will help you verify the safety of your health, so don't ignore it!
In addition, you can refer to reviews from users to make sure that the product you buy is really reputable and effective. At the same time, don't forget to ask medical experts before using to ensure your own health.
Conclusion
So, through the above article, we have helped you understand that NMNH has the ability to work faster and more widely in enhancing NAD + for our body.
However, confirming whether NMN is better than NMNH will depend on your body and your purpose of use. We hope that through the article, you can choose the most suitable supplement for yourself.
References
- [1] Cantó, C., Menzies, K. J., & Auwerx, J. (2015). NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC4487780/
- [2] Liu Y;Luo C;Li T;Zhang W;Zong Z;Liu X;Deng H; (n.d.). Reduced Nicotinamide Mononucleotide (NMNH) Potentially Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. Retrieved from https://pubmed.ncbi.nlm.nih.gov/33793246/
- [3] Zapata‐Pérez, R., Tammaro, A., Schomakers, B. V., Scantlebery, A. M., Denis, S., Elfrink, H. L., … Houtkooper, R. H. (2021). The FASEB Journal, 35(4). doi:10.1096/fj.202001826r
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