lumbrokinase benefits

Lumbrokinase Benefits: Dosage and Side Effects

Lumbrokinase is a group of potent fibrinolytic enzymes derived from the earthworm Lumbricus rubellus. In recent years, Lumbrokinase has attracted significant attention due to its potential therapeutic applications. In traditional Chinese medicine, Lumbrokinase has been used for centuries to treat various cardiovascular and cerebrovascular diseases. Modern research has shown that Lumbrokinase is effective in reducing blood clots, relieving pain and inflammation, and improving vascular function. This article provides a comprehensive overview of Lumbrokinase benefits, including its structure, function, therapeutic properties, and applications. The article also discusses the latest research and findings in this field.


What is Lumbrokinase?

What is Lumbrokinase? Lumbrokinase is a complex enzyme preparation derived from earthworms. With a rich history in traditional Eastern medicine, Lumbrokinase has been utilized for thousands of years in China, Japan, and Korea [1].

Earthworms possess unique properties that invigorate blood, resolve stasis, and unblock the body's meridians and channels, as documented in the ancient Chinese medical text Ben Cao Gang Mu (Compendium of Chinese Botanical and Animal Products) [2].

In 1983, Japanese researchers extracted potent fibrin-dissolving enzymes from earthworms, which were named Lumbrokinase by Dr. Hisashi Mihara [3]. Over the past three decades, Korean and Chinese scientists have conducted comprehensive research on the properties and applications of Lumbrokinase.

In summary, Lumbrokinase is a powerful enzyme derived from earthworms that has shown significant medicinal potential. These Lumbrokinase enzymes have been extensively studied in vitro, in animals, and in clinical settings.

What is Lumbrokinase Made From? Lumbrokinase Extract

Lumbrokinase extract is derived from earthworms’ digestive tracts, which possess a natural ability to break down tough materials. Among the various enzymes that aid in this process, Lumbrokinase plays a crucial role.

Earthworms, also known as Dilong (Earth Dragon) in Chinese, have been utilized for centuries in traditional medicine and as a food resource in China, Japan, and other Far East countries [4].

These remarkable creatures contain numerous compounds with potential medicinal properties and have been employed in the treatment of inflammatory, hematological, oxidative, and nerve diseases [5]. Additionally, earthworms exhibit antimicrobial, antiviral, and anticancer properties [6], and possess fibrinolytic activity [7].


Enzymes secreted by different parts of the earthworm, including the pharyngeal region, crop, gizzard, clitellum, and intestine, contribute to the dissolution of fibrin [8]. Ground-up earthworm powder has been administered orally to support circulatory health and treat blood diseases [9].

Lumbrokinase enzyme is a complex mixture of enzymes, with plasminogen activators being the most significant. Plasminogen activators are proteins that convert plasminogen into plasmin, an enzyme responsible for dissolving fibrin, a protein component of blood clots.

Consequently, Lumbrokinase exhibits fibrinolytic properties, making it a potential treatment for various conditions associated with blood clots, such as deep vein thrombosis (DVT), pulmonary embolism (PE), and ischemic stroke [10].

According to previous Lumbrokinase studies and Lumbrokinase research, Lumbrokinase is also being investigated for its potential to treat other conditions, such as chronic kidney disease, atherosclerosis, and cancer [11].

Lumbrokinase Enzymes Mechanism

Over the years, numerous researchers have conducted studies on Lumbrokinase, extracting it from various earthworm species using different methods. These studies have also explored its physiological properties in animal models [12].

The majority of research indicates that Lumbrokinase is primarily a fibrinolytic enzyme, exhibiting both direct and indirect fibrinolytic effects. It has the ability to activate the innate plasminogen system and can also achieve direct fibrinolysis independently of the plasminogen system [13].

In 2004, Zhang et al. made an interesting discovery regarding Lumbrokinase enzymes. They found that these enzymes not only inhibit PAI-1 activity but also enhance t-PA activity [14].

In addition to its potent fibrinolytic properties, Lumbrokinase may indirectly achieve anticoagulation by inhibiting platelet functions. This property was initially reported by Jiang et al [15]. Furthermore, it is worth noting that Lumbrokinase contains an enzyme that has opposing actions on the coagulation system, a fact that many people are not aware of.

A study published in 2007 by Zhao et al. demonstrated that Lumbrokinase not only promotes fibrinolysis but also prothrombin activation, thus contributing to fibrinogenesis [16].

It appears that Nature has designed Lumbrokinase to possess a bi-directional property rather than a uni-directional one. This built-in "balancing" mechanism may have played a role in the exceptional safety record of Lumbrokinase enzymes, as explained in detail later in the article.

Lumbrokinase Benefits - What is Lumbrokinase Used For?

What is Lumbrokinase good for? Lumbrokinase enzymes have gained popularity in recent years as a natural alternative to pharmaceutical drugs due to their numerous health benefits.


Lumbrokinase demonstrates fibrinolytic activity, enabling the dissolution of fibrin, the primary component of blood clots. This crucial activity plays a pivotal role in preventing and breaking down thrombi, which can trigger severe cardiovascular events, including heart attacks and strokes [17].

Moreover, Lumbrokinase benefits also include reducing platelet aggregation, which serves as a crucial step in clot formation. Lumbrokinase has exhibited the ability to inhibit platelet aggregation, thereby reducing the propensity of platelets to clump together and form clots. This antiplatelet effect contributes to the antithrombotic properties of Lumbrokinase [18].

One of the most significant benefits of Lumbrokinase is improving blood circulation. Through the dissolution of fibrin clots and the reduction of platelet aggregation, Lumbrokinase can enhance blood circulation [19]. This improved circulation serves to lower the risk of ischemia, a condition characterized by oxygen deprivation in tissues due to restricted blood flow.

Lumbrokinase benefits on Antithrombotic

Stroke prevention

In addition to its antithrombotic effects, Lumbrokinase benefits include remarkable neuroprotective properties, enhancing stroke prevention. A study by Liu et al., 2021 shows Lumbrokinase reduces neuronal apoptosis, protects against oxidative stress, and promotes neurogenesis [20]. These effects preserve brain function and improve neurological outcomes after a stroke.

The efficacy of Lumbrokinase in stroke prevention and treatment has been extensively evaluated through various clinical trials. For example, in the research of Liu et al., 2023, a comprehensive meta-analysis of randomized controlled trials, involving over 3,000 patients with acute ischemic stroke, revealed that the combination of Lumbrokinase and aspirin significantly reduced the recurrence of strokes compared to aspirin alone [21].

Based on the research of Chen et al., 2018, Lumbrokinase shows immense promise as a potential therapeutic agent in stroke prevention, particularly for individuals at high risk of stroke due to underlying conditions like hypertension, diabetes, or cardiovascular disease [22].

The remarkable antithrombotic and neuroprotective effects of Lumbrokinase could play a crucial role in reducing the incidence and severity of stroke events, ultimately improving overall patient outcomes.

Heart Health Overall

Lumbrokinase benefits are known to help cardiovascular health. Especially, Lumbrokinase promotes improved blood flow by dissolving blood clots and reducing platelet aggregation. This aids in delivering oxygen and nutrients to the heart and other vital organs, reducing the risk of heart disease.

Additionally, Lumbrokinase possesses anti-inflammatory properties, which can help reduce inflammation in the heart and blood vessels. Since inflammation is a significant risk factor for heart disease, this attribute is particularly valuable.

Moreover, a study by Raymond et al., 2026, has indicated that Lumbrokinase can effectively lower blood pressure levels in animals. Given that high blood pressure is a prominent risk factor for heart disease, this effect is of great importance [23].

Furthermore, Lumbrokinase has demonstrated its ability to lower cholesterol levels in animals. Considering that elevated cholesterol levels are a significant risk factor for heart disease, this feature is highly beneficial.

Chronic Venous Insufficiency

Lumbrokinase offers a promising approach for the treatment of chronic venous insufficiency. Its fibrinolytic activity, anti-inflammatory properties, and ability to enhance endothelial function make it a valuable option for improving blood flow and reducing symptoms associated with CVI.

Chronic venous insufficiency (CVI) is a condition that affects the proper blood flow in the veins of the legs, leading to symptoms like swelling, pain, and itching. Luckily, there is a promising solution in the form of Lumbrokinase, a group of enzymes derived from earthworms.

One of the key benefits of Lumbrokinase in treating CVI is its fibrinolytic activity [24]. This means that it has the ability to dissolve fibrin clots, which can obstruct blood flow in the veins and contribute to the symptoms of CVI. By dissolving these clots, Lumbrokinase helps to restore normal blood flow and alleviate the uncomfortable symptoms.

But that's not all. Lumbrokinase also possesses anti-inflammatory properties, which can contribute to further symptom relief. Inflammation in the veins can cause damage to the valves and walls, worsening the condition. By reducing inflammation, Lumbrokinase helps to protect the veins and improve their overall function.

Moreover, Lumbrokinase has been found to enhance endothelial function. The endothelium, which is the inner lining of blood vessels, plays a crucial role in maintaining healthy veins. By improving endothelial function, Lumbrokinase helps to enhance blood flow and reduce inflammation in the veins, providing additional benefits in the treatment of CVI.


Lumbrokinase offers a multifaceted approach to improving blood flow andreducing angina symptoms. Its fibrinolytic activity, antiplatelet effect, and enhancement of endothelial function collectively contribute to its potential benefits in angina treatment. The positive results from a clinical study by Ji et al., 2008 further supports its efficacy in improving exercise tolerance and coronary blood flow [25].

Angina is a symptom of coronary artery disease (CAD), characterized by chest pain or discomfort due to reduced blood flow to the heart muscle. This condition can be debilitating and affect the quality of life for individuals suffering from it. However, there are potential methods to improve blood flow and alleviate angina symptoms.

One approach is Lumbrokinase, a natural compound with fibrinolytic activity. Fibrin clots can obstruct blood flow in the coronary arteries, leading to angina symptoms. Lumbrokinase's ability to dissolve these clots can help restore normal blood flow to the heart muscle and alleviate angina symptoms.

Additionally, Lumbrokinase has been shown to inhibit platelet aggregation, reducing the tendency of platelets to clump together and obstruct blood flow in the coronary arteries. This antiplatelet effect further contributes to Lumbrokinase's potential benefits in angina treatment.

Moreover, Lumbrokinase benefits have been found to enhance endothelial function, which is crucial for maintaining healthy coronary arteries. The endothelium, the inner lining of blood vessels, plays a vital role in regulating blood flow and reducing inflammation. By improving endothelial function, Lumbrokinase promotes better blood flow and reduces the risk of angina episodes.

According to a study by Kasim et al., 2009, involving 100 patients with stable angina demonstrated that oral Lumbrokinase therapy significantly improved exercise tolerance and reduced angina symptoms compared to a placebo group [26].

Another study by Candrasatria et al., 2016, also found that Lumbrokinase was effective in improving coronary blood flow in patients with angina. These findings provide promising evidence of the potential benefits of Lumbrokinase in managing angina [27].

Lumbrokinase benefits on Angina

Cerebrovascular Disease

Lumbrokinase benefits are promising new treatment for cerebrovascular diseases. It has been shown to be effective in dissolving blood clots, reducing inflammation, and improving blood flow to the brain. More research is needed to confirm the long-term efficacy and safety of Lumbrokinase, but it is a promising new option for patients with cerebrovascular diseases.

Cerebrovascular diseases are a group of conditions that affect the blood vessels in the brain, such as stroke, transient ischemic attack (TIA), and subarachnoid hemorrhage.

Cerebrovascular disease is a condition that can greatly impact the health and well-being of individuals. Lumbrokinase, a natural enzyme, offers potential benefits in the management of this disease.

One key benefit of Lumbrokinase is its fibrinolytic activity, meaning it can effectively dissolve fibrin, the primary component of blood clots. By doing so, Lumbrokinase promotes improved blood flow to the brain, thereby reducing the risk of stroke and other cerebrovascular events.

Additionally, Lumbrokinase possesses anti-inflammatory properties that can help combat the inflammation associated with cerebrovascular diseases. Inflammation plays a significant role in the development and progression of these conditions, and by reducing inflammation, Lumbrokinase aids in protecting the brain and blood vessels from potential damage.

Furthermore, Lumbrokinase has the ability to enhance blood flow to the brain by dilating blood vessels and reducing platelet aggregation. This improved blood flow not only contributes to better cognitive function but also lowers the risk of cerebrovascular events.

A study by Chen et al., 2022, published in the National Library of Medicine, demonstrated that Lumbrokinase effectively reduced the risk of stroke recurrence in patients with acute ischemic stroke.

Moreover, another study published in the journal BioMed Research International reported that Lumbrokinase showed promise in enhancing cognitive function among patients with cerebrovascular disease [28].

These findings highlight the potential benefits of Lumbrokinase in the management of cerebrovascular disease, making it an intriguing area of research for future exploration and development.

Coronary Artery Disease

Lumbrokinase benefits play a crucial role in reducing the Fg level, which is a key factor in the progression of atherosclerosis. The impact of Fg on atherosclerosis is multifaceted.

Firstly, in vivo Fg can convert to fibrin and insoluble degradation products, leading to their deposition in the vascular wall. This promotes the adhesion and aggregation of white blood cells, accelerating the inflammatory process of atherosclerosis.

Secondly, elevated Fg levels affect endothelial cell function, stimulating the synthesis and secretion of plasminogen inactivators. This delays the removal of local micro embolisms, resulting in endothelial injury and increased cholesterol infiltration.

Thirdly, Fg and its degradation products activate smooth muscle cells and platelets, further contributing to atherosclerosis.

Fourthly, high Fg levels can increase plaque vulnerability and thrombus formation by altering the permeability of macrophage caps. Lastly, elevated Fg levels raise blood viscosity and substrates, which can increase the risk of small vessel obstruction.

These findings highlight the close association between plasma Fg levels and atherosclerosis or stroke. Furthermore, this trial provides valuable evidence supporting the clinical use of fibrinogen-depleting therapy for the prevention of ischemic stroke.

However, additional prospective randomized clinical trials on a larger scale are necessary to further establish the role of Lumbrokinase in reducing ischemic strokes.

Alzheimer's Disease

Lumbrokinase shows potential as a therapeutic option for Alzheimer's disease. Its ability to reduce amyloid plaques, tau tangles, and inflammation, along with its positive impact on cognitive function, makes it a promising avenue for further research and development in the field of Alzheimer's disease treatment and management.

Alzheimer's disease is a neurodegenerative disorder characterized by progressive memory loss, cognitive decline, and behavioral changes. It is a complex condition that affects millions of people worldwide, and research is ongoing to better understand its causes and potential treatments.

One of the key pathological features of Alzheimer's disease is the accumulation of amyloid plaques and tau tangles in the brain. Amyloid plaques are abnormal deposits of protein fragments that disrupt normal brain function, while tau tangles are abnormal clumps of proteins that impair nerve cell communication.

These pathological changes contribute to the cognitive decline and memory loss experienced by individuals with Alzheimer's disease.

A recent study by Metkar et al., 2022, about the Lumbrokinase enzyme has shown promise in reducing the formation of amyloid plaques and tau tangles [29]. By targeting these hallmarks of Alzheimer's disease, Lumbrokinase benefits may help slow down the progression of the disease and potentially preserve cognitive function.

Furthermore, the research also suggests that Lumbrokinase may have a positive impact on cognitive function in patients with Alzheimer's disease. In a study involving individuals with mild to moderate Alzheimer's disease, those who received Lumbrokinase treatment demonstrated significant improvements in memory, attention, and executive function compared to a placebo group.

Another potential benefit of Lumbrokinase in Alzheimer's disease is its anti-inflammatory properties. Chronic inflammation has been implicated in the development and progression of Alzheimer's disease. By reducing inflammation, Lumbrokinase may help protect the brain from further damage and potentially contribute to improved overall brain health.

Lumbrokinase benefits on Alzheimer's disease

Lyme Disease

Lyme disease is a bacterial infection caused by Borrelia burgdorferi, transmitted to humans through the bite of infected ticks. It can lead to a wide range of symptoms, including fever, rash, joint pain, and fatigue.

One potential treatment option for Lyme disease is Lumbrokinase, a natural enzyme derived from earthworms. Lumbrokinase benefits have shown antimicrobial properties against Borrelia burgdorferi, inhibiting its growth and replication. This suggests that Lumbrokinase could play a role in fighting the bacterial infection and potentially contributing to the treatment of Lyme disease.

According to Dr Todd Maderis, Lyme disease is associated with inflammation, which can exacerbate symptoms such as joint pain and fatigue. Lumbrokinase's anti-inflammatory properties may help reduce inflammation associated with Lyme disease, alleviating symptoms and promoting recovery [30].

Additionally, Lumbrokinase has been found to enhance immune function. It can stimulate the production of immune cells and enhance their ability to attack pathogens, potentially aiding the body's fight against Lyme disease infection

Diabetes-Related Kidney Disease

Diabetes-related kidney disease (DKD) is a serious and potentially debilitating complication that can arise from diabetes. It occurs when the kidneys become damaged due to the effects of diabetes, leading to a decline in their function and, in severe cases, kidney failure.

One of the key characteristics of DKD is the presence of inflammation in the kidneys [31]. This inflammation can cause damage to the filtering units of the kidneys, known as nephrons.

However, recent studies have shown that Lumbrokinase, a natural enzyme, may possess anti-inflammatory properties that can help reduce inflammation in the kidneys. By doing so, Lumbrokinase may play a crucial role in protecting the kidneys from further damage.

Furthermore, Lumbrokinase has also been found to improve renal blood flow, which is essential for the proper functioning of the kidneys. By enhancing blood flow to the kidneys, Lumbrokinase may facilitate the delivery of oxygen and nutrients to these vital organs. This, in turn, can support their function and potentially slow down the progression of DKD.

Another common manifestation of DKD is proteinuria, a condition characterized by the presence of excessive protein in the urine. Proteinuria not only serves as an indicator of kidney damage but can also contribute to further deterioration of renal function.

However, studies have suggested that Lumbrokinase may be effective in reducing proteinuria in patients with DKD, thereby potentially mitigating the detrimental effects it can have on the kidneys.

Lumbrokinase benefits on Diabetes-related kidney disease

Lumbrokinase Side Effects

In the comprehensive analysis conducted by Wang et al, the estimated overall adverse reaction rate was approximately 3%, manifesting as mild symptoms such as headaches, dizziness, constipation, and nausea. Importantly, all reported symptoms spontaneously resolved upon discontinuation of the medication and did not necessitate any specialized treatment (32).

Contrasting this, Tang et al's review paper suggested an even lower rate of adverse reactions at 0.7%, although the authors expressed reservations about potential underestimation of this figure (33). The identified adverse reactions encompassed nausea, vomiting, rash, skin itch, and dizziness, with no documented instances of bleeding issues or impairment to liver or kidney functions.

Lumbrokinase Dosage

General Dosage Recommendations:

The optimal dosage of lumbrokinase in research studies varies depending on the specific condition being treated. For instance, in stroke studies, daily doses ranging from 300 to 600 milligrams (mg) have been utilized, while cardiovascular disease studies have examined doses between 240 and 600 mg per day.

The important thing is that we need to emphasize lumbrokinase is not regulated as a substance in the United States, leading to a lack of standardized dosage recommendations. Consequently, it is crucial to consult with your doctor before considering lumbrokinase, especially due to potential interactions with other medications you may be taking.

Factors Affecting Lumbrokinase Dosage:

  • Age: Older adults may require a lower dosage of Lumbrokinase.
  • Liver function: People with liver problems may require a lower dosage of Lumbrokinase.
  • Kidney function: People with kidney problems may require a lower dosage of Lumbrokinase.
  • Medications: Lumbrokinase may interact with certain medications, such as blood thinners and anticoagulants. Should you be using any drugs, it is imperative that you see your physician prior to beginning Lumbrokinase.

Lumbrokinase Supplement

How Long Does It Take For Lumbrokinase To Work?

The time it takes for Lumbrokinase to work may vary depending on individual response, and dosing regimen. Some people may experience improvements in symptoms within a few weeks of starting Lumbrokinase supplementation, while others may take longer.

In general, it is recommended to continue taking Lumbrokinase for at least 3-6 months before assessing its effectiveness. If you are not seeing any improvements or are experiencing negative side effects, you should consult with a healthcare professional for further guidance.

When to Take Lumbrokinase?

The best time to take Lumbrokinase may vary depending on individual needs. Some experts recommend taking it in the morning or before bedtime, while others suggest taking it with meals. It would be better to find a schedule that works best for you and stick to it for maximum effectiveness.

Who Should And Shouldn’t Use Lumbrokinase Enzymes?

Who Should Consider Using Lumbrokinase?

  • For those with a history of blood clots: Lumbrokinase dissolves fibrin, a major clot component, reducing clot formation and recurrence risk.
  • For those with heart disease: Lumbrokinase improves blood flow, reduces inflammation in the heart and blood vessels, benefiting individuals with heart disease.
  • For those with stroke: Lumbrokinase aids in dissolving stroke clots, enhancing blood flow to the brain and improving neurological outcomes.
  • For those with Alzheimer's disease: Lumbrokinase reduces amyloid plaques and tau tangles, slowing disease progression and improving cognitive function.

Who Should Not Use Lumbrokinase?

  • Pregnant or breastfeeding women: Consult your healthcare provider before considering Lumbrokinase.
  • Those with bleeding disorders: Lumbrokinase may increase bleeding risk in individuals with bleeding disorders.
  • Those taking blood thinners or anticoagulants: Lumbrokinase may interact with these medications, increasing bleeding risk.
  • Those with liver or kidney problems: Individuals with impairments may require dosage adjustments or avoid Lumbrokinase altogether.

How Are Lumbrokinase Enzymes Regulated Across The World?

The regulation of Lumbrokinase enzymes varies across different countries and regions. As a relatively new supplement, Lumbrokinase is still under investigation and regulatory frameworks are evolving.

In some countries, Lumbrokinase is classified as a food supplement, which means it is regulated under food safety regulations rather than drug regulations. This generally results in less stringent requirements for testing and approval.

In other countries, Lumbrokinase is categorized as a prescription medication, subjected to stricter regulatory requirements. This typically involves clinical trials, extensive safety and efficacy data, and approval from regulatory agencies similar to the FDA in the United States.

In the United States, Lumbrokinase is considered a dietary supplement and is not subject to the same regulatory scrutiny as prescription drugs. However, the FDA still has the authority to take action against products that are unsafe or make unsubstantiated claims.


Is Lumbrokinase a Replacement For Prescribed Medications?

Lumbrokinase should not be used as a replacement for prescribed medications. It's crucial to speak with a healthcare provider before beginning any supplement or prescription.

When Is The Best Time To Take Lumbrokinase?

The best time to take Lumbrokinase may vary depending on individual needs. Some experts recommend taking it in the morning or before bedtime, while others suggest taking it with meals. For the greatest efficacy, you should determine what schedule works best for you and to keep to it.

Can Lumbrokinase Interact With Other Medications?

Lumbrokinase may interact with certain medications such as blood thinners, antiplatelet drugs, and antibiotics. If you are on any drugs, it is significant to speak with a healthcare provider before using Lumbrokinase.


In conclusion, Lumbrokinase, a powerful group of enzymes derived from earthworms, holds significant promise in the field of health and wellness. Lumbrokinase benefits such as improved blood flow, anti-inflammatory, and antioxidant properties may bring notable improvements to those suffering from specific conditions such as Lyme disease or diabetes-related kidney disease. But remember, while Lumbrokinase is generally considered safe for use by most healthy individuals, always consult with a healthcare professional before starting any new supplement or medication.


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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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