lumbrokinase benefits

Lumbrokinase Benefits: Dosage and Side Effects

Lumbrokinase is a group of potent fibrinolytic enzymes derived from the earthworm Lumbricus rubellus. In recent years, Lumbrokinase has attracted significant attention due to its potential therapeutic applications. In traditional Chinese medicine, Lumbrokinase has been used for centuries to treat various cardiovascular and cerebrovascular diseases. Modern research has shown that Lumbrokinase is effective in reducing blood clots, relieving pain and inflammation, and improving vascular function. This article provides a comprehensive overview of Lumbrokinase benefits, including its structure, function, therapeutic properties, and applications. The article also discusses the latest research and findings in this field.

Before exploring further, please read the disclaimer located at the end of this webpage.

What is Lumbrokinase?

Lumbrokinase is a complex enzyme preparation derived from earthworms, specifically Lumbricus rubellus. Its use has deep roots in traditional Eastern medicine, particularly in China, Japan, and Korea. This enzyme has been celebrated for its ability to invigorate blood flow, resolve stasis, and unblock the body's meridians and channels, as described in the ancient Chinese text Ben Cao Gang Mu (Compendium of Chinese Botanical and Animal Products) [1].

In 1983, Dr. Hisashi Mihara and Japanese researchers isolated potent fibrin-dissolving enzymes from earthworms, naming this enzyme complex Lumbrokinase [2]. Since then, Lumbrokinase has garnered significant attention for its potential health benefits, especially in cardiovascular support. It is now available under various trade names, including Boluoke and Lumbrokinase Nattokinase.

Research on Lumbrokinase has been extensive and global. Institutions in China, Japan, and the United States have conducted numerous studies, focusing on its efficacy in breaking down fibrin—a protein involved in blood clotting. This action helps enhance blood flow and prevent clot formation, offering potential support in reducing the risk of cardiovascular events such as stroke and myocardial infarction.

What is Lumbrokinase Made From? Lumbrokinase Extract

Lumbrokinase extract is derived from earthworm Lumbricus rubellus digestive tracts, which have a natural ability to break down tough materials. Lumbrokinase is one of the key enzymes involved in this process.

Different parts of the earthworm, including the pharyngeal region, crop, gizzard, clitellum, and intestine, secrete enzymes that help dissolve fibrin [8]. Oral administration of powdered earthworm extract has been used to support circulatory health and treat blood disorders [9].

Lumbrokinase is a complex enzyme blend, with plasminogen activators being the most important. These activators convert plasminogen into plasmin, an enzyme that breaks down fibrin, a protein involved in blood clotting.

Thus, Lumbrokinase has fibrinolytic properties and may help treat conditions related to blood clots, such as deep vein thrombosis (DVT), pulmonary embolism (PE), and ischemic stroke [10].

Additionally, ongoing research is examining Lumbrokinase's potential to treat other conditions, such as chronic kidney disease, atherosclerosis [11].

Earthworms

Lumbrokinase Benefits - What is Lumbrokinase Used For?

What is Lumbrokinase good for? Lumbrokinase enzymes have gained popularity in recent years as a natural alternative to pharmaceutical drugs due to their numerous health benefits.

Stroke Prevention

Lumbrokinase is noted for its ability to reduce the risk of stroke by preventing the formation of blood clots. Clinical studies have demonstrated that it can lower the recurrence rates of strokes without increasing the risk of bleeding events.

Beyond its antithrombotic effects, Lumbrokinase also offers neuroprotective benefits. Research by Liu et al. (2021) highlights that Lumbrokinase can reduce neuronal apoptosis, protect against oxidative stress, and promote neurogenesis. These effects help preserve brain function and improve neurological outcomes following a stroke [20].

The effectiveness of Lumbrokinase in stroke prevention has been supported by various clinical trials.

For instance, Liu et al. (2023) conducted a meta-analysis involving over 3,000 patients with acute ischemic stroke, finding that Lumbrokinase combined with aspirin significantly reduced stroke recurrence compared to aspirin alone [21].

Lumbrokinase Benefits for Cardiovascular Health

Lumbrokinase is a powerful enzyme that plays a crucial role in supporting cardiovascular health. It primarily works by breaking down fibrin, a protein involved in blood clotting, which helps dissolve blood clots and enhances blood circulation. This action reduces the risk of conditions such as myocardial infarction (heart attack) and deep vein thrombosis (DVT).

Additionally, Lumbrokinase improves blood flow by reducing platelet aggregation, ensuring that oxygen and nutrients are efficiently delivered to the heart and other vital organs. This promotes overall heart health and lowers the risk of heart disease [23].

Moreover, studies have also indicated that Lumbrokinase can lower blood pressure and cholesterol levels, further supporting cardiovascular health and reducing the risk of heart-related conditions.

Chronic Venous Insufficiency

Lumbrokinase is a promising supplement for chronic venous insufficiency (CVI) due to its fibrinolytic activity, anti-inflammatory effects, and ability to improve endothelial function [24].

CVI occurs when blood flow in the leg veins is impaired, causing symptoms like swelling, pain, and itching.

One key benefit of Lumbrokinase is its ability to dissolve fibrin clots [24]. These clots can block blood flow in veins, leading to discomfort. By dissolving them, Lumbrokinase restores normal circulation and relieves symptoms.

Lumbrokinase also reduces inflammation, protects the veins, improves endothelial function, and enhances their function, which is crucial since inflammation can damage vein valves and walls, worsening CVI.

Angina

Lumbrokinase provides a multi-pronged approach to improving blood flow and reducing angina symptoms. Its ability to dissolve clots, prevent platelet aggregation, and enhance endothelial function makes it effective in treating angina.

Lumbrokinase also prevents platelets from clumping together, which reduces the risk of further blockages in the coronary arteries. Additionally, it improves the function of the endothelium—the inner lining of blood vessels—promoting better circulation and lowering the chances of angina episodes.

A study by Kasim et al., 2009, involving 100 patients with stable angina, found that Lumbrokinase significantly improved exercise tolerance and reduced symptoms compared to a placebo [26].

Another study by Candrasatria et al., 2016, showed that Lumbrokinase also improved coronary blood flow in angina patients, highlighting its potential in managing the condition [27].

Lumbrokinase benefits on Angina

Alzheimer's Disease

Lumbrokinase shows promise as a supplement for managing Alzheimer's disease. It reduces amyloid plaques, tau tangles, and inflammation, and it also improves cognitive function.

Alzheimer's disease is a neurodegenerative disorder that causes memory loss, cognitive decline, and behavioral changes. A key feature of Alzheimer's is the buildup of amyloid plaques and tau tangles in the brain.

A study by Metkar et al., 2022, found that Lumbrokinase can reduce amyloid plaques and tau tangles [29]. By targeting these aspects of Alzheimer's, Lumbrokinase may slow the disease's progression and preserve cognitive function.

You may also like: Is Lumbrokinase A Blood Thinner?

Lumbrokinase Side Effects

Lumbrokinase may cause some mild side effects, such as headaches, dizziness, constipation, nausea, and sometimes diarrhea. These symptoms usually go away on their own once you stop using the supplement and typically don’t require special treatment.

In rare cases, lumbrokinase can cause allergic reactions, like skin rashes or itching. If you experience these, you should stop using the product right away.

If you have allergies to earthworms or other ingredients in the supplement, you should avoid lumbrokinase. People with bleeding disorders, like hemophilia, or those taking blood-thinning or antiplatelet medications should be cautious and consult a healthcare provider before using it due to the increased risk of bleeding. Pregnant or breastfeeding women should also seek medical advice to ensure the supplement is safe for them.

Lumbrokinase Dosage

General Dosage Recommendations:

The optimal dosage of lumbrokinase in research studies varies depending on the specific condition being treated. For instance, in stroke studies, daily doses ranging from 300 to 600 milligrams (mg) have been utilized, while cardiovascular disease studies have examined doses between 240 and 600 mg per day.

The important thing is that we need to emphasize lumbrokinase is not regulated as a substance in the United States, leading to a lack of standardized dosage recommendations. Consequently, it is crucial to consult with your doctor before considering lumbrokinase, especially due to potential interactions with other medications you may be taking.

Factors Affecting Lumbrokinase Dosage:

  • Age: Older adults may require a lower dosage of Lumbrokinase.
  • Liver function: People with liver problems may require a lower dosage of Lumbrokinase.
  • Kidney function: People with kidney problems may require a lower dosage of Lumbrokinase.
  • Medications: Lumbrokinase may interact with certain medications, such as blood thinners and anticoagulants. Should you be using any drugs, it is imperative that you see your physician prior to beginning Lumbrokinase.

Lumbrokinase Supplement

How Long Does It Take For Lumbrokinase To Work?

The time it takes for Lumbrokinase to work may vary depending on individual response, and dosing regimen. Some people may experience improvements in symptoms within a few weeks of starting Lumbrokinase supplementation, while others may take longer.

In general, it is recommended to continue taking Lumbrokinase for at least 3-6 months before assessing its effectiveness. If you are not seeing any improvements or are experiencing negative side effects, you should consult with a healthcare professional for further guidance.

When to Take Lumbrokinase?

The best time to take Lumbrokinase may vary depending on individual needs. Some experts recommend taking it in the morning or before bedtime, while others suggest taking it with meals. It would be better to find a schedule that works best for you and stick to it for maximum effectiveness.

Who Should And Shouldn’t Use Lumbrokinase Enzymes?

Who Should Consider Using Lumbrokinase?

  • For those with a history of blood clots: Lumbrokinase dissolves fibrin, a major clot component, reducing clot formation and recurrence risk.
  • For those with heart disease: Lumbrokinase improves blood flow, reduces inflammation in the heart and blood vessels, benefiting individuals with heart disease.
  • For those with stroke: Lumbrokinase aids in dissolving stroke clots, enhancing blood flow to the brain and improving neurological outcomes.
  • For those with Alzheimer's disease: Lumbrokinase reduces amyloid plaques and tau tangles, slowing disease progression and improving cognitive function.

Who Should Not Use Lumbrokinase?

  • Pregnant or breastfeeding women: Consult your healthcare provider before considering Lumbrokinase.
  • Those with bleeding disorders: Lumbrokinase may increase bleeding risk in individuals with bleeding disorders.
  • Those taking blood thinners or anticoagulants: Lumbrokinase may interact with these medications, increasing bleeding risk.
  • Those with liver or kidney problems: Individuals with impairments may require dosage adjustments or avoid Lumbrokinase altogether.

How Are Lumbrokinase Enzymes Regulated Across The World?

The regulation of Lumbrokinase enzymes varies across different countries and regions. As a relatively new supplement, Lumbrokinase is still under investigation and regulatory frameworks are evolving.

In some countries, Lumbrokinase is classified as a food supplement, which means it is regulated under food safety regulations rather than drug regulations. This generally results in less stringent requirements for testing and approval.

In other countries, Lumbrokinase is categorized as a prescription medication, subjected to stricter regulatory requirements. This typically involves clinical trials, extensive safety and efficacy data, and approval from regulatory agencies similar to the FDA in the United States.

In the United States, Lumbrokinase is considered a dietary supplement and is not subject to the same regulatory scrutiny as prescription drugs. However, the FDA still has the authority to take action against products that are unsafe or make unsubstantiated claims.

Read more: Can You Take Serrapeptase And Lumbrokinase Together?

Frequently Asked Questions

Is Lumbrokinase a Replacement For Prescribed Medications?

Lumbrokinase should not be used as a replacement for prescribed medications. It's crucial to speak with a healthcare provider before beginning any supplement or prescription.

When Is The Best Time To Take Lumbrokinase?

The best time to take Lumbrokinase may vary depending on individual needs. Some experts recommend taking it in the morning or before bedtime, while others suggest taking it with meals. For the greatest efficacy, you should determine what schedule works best for you and to keep to it.

Can Lumbrokinase Interact With Other Medications?

Lumbrokinase may interact with certain medications such as blood thinners, antiplatelet drugs, and antibiotics. If you are on any drugs, it is significant to speak with a healthcare provider before using Lumbrokinase.

Conclusion

In conclusion, Lumbrokinase, a powerful group of enzymes derived from earthworms, holds significant promise in the field of health and wellness. Lumbrokinase benefits such as improved blood flow, anti-inflammatory, and antioxidant properties may bring notable improvements to those suffering from specific conditions such as Lyme disease or diabetes-related kidney disease. But remember, while Lumbrokinase is generally considered safe for use by most healthy individuals, always consult with a healthcare professional before starting any new supplement or medication.

References

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Author

Ralph S Albert
Ralph S Albert
Ralph S. Albert is an esteemed professional with a remarkable career spanning over 15 years in the dynamic and ever-evolving realm of the food and nutrition industry. Currently, Ralph proudly serves as the Head of Research at Vinatura Supplements, a leading company in the dietary supplement industry. His work is characterized by a dedication to innovation, compliance, and the application of scientific research to create natural, yet practical solutions for consumers.
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