Can You Take Serrapeptase And Lumbrokinase Together

Can You Take Serrapeptase And Lumbrokinase Together?

Serrapeptase and Lumbrokinase are advanced enzymes that can support health and are beneficial in reducing inflammation, preventing blood clots, and improving blood circulation.

So, can you use Serrapeptase and Lumbrokinase together? The answer is yes. However, further research is needed. Follow more reasons and specific instructions in the article below.


Key Takeaways

  • Studies have mentioned the benefits of combining Serrapeptase and Lumbrokinase; however, few studies have discussed the side effects and how to combine them.
  • Serrapeptase and lumbrokinase are compounds beneficial for health, reducing inflammation, preventing blood clots, and improving blood circulation.
  • These compounds also cause few side effects but are not too dangerous.
  • The combined dosage has not been released but should not be used separately in overdose.

Can You Take Serrapeptase And Lumbrokinase Together?

you can take nattokinase and serrapeptase together

There is not enough scientific evidence to determine whether Serrapeptase and Lumbrokinase can be used safely and effectively together.

However, a few studies show the combination potential of Serrapeptase and Lumbrokinase in treating Prion disease and preventing Alzheimer's disease.

One study combined the enzyme Lumbrokinase isolated from earthworms and the enzyme Serratiopeptidase (Serrapeptase), taking Nattokinase as a standard.

The results showed that the formation of amyloid PrP 106-126 (region within PrPSc peptide related to trembling and Prion disease) was inhibited by both Lumbrokinase and Serrapeptase.

Furthermore, the size of the small fibers was also lower at different times after incubating the prion amyloid with LK and SP.

Overall, the study concluded that serine proteases such as Lumbrokinase and Serrapeptase can degrade amyloid PrP 106-126 with improved cell survival [1].

The second study talks about the potential of Lumbrokinase and Serratiopeptidase for Alzheimer's disease.

The study with a similar implementation method between Lumbrokinase and Serratiopeptidase not only shows promising results in degrading amyloid Aβ 1-42 (insoluble plaques in the brain cells leading to memory loss) but can also reduce toxicity, making them suitable candidates for AD drug [2].

What Are Serrapeptase?

what are serrapeptase

Serrapeptase, also known as serratiopeptidase, is a chemical compound found in silkworms and is regarded as a powerful protein-breaking enzyme that helps promote healthy respiratory, lung, joint, muscle, sinus, and tissue systems.

It has been widely used as a safe and effective dietary supplement for over 50 years worldwide, with popular consumption in Japan and Europe.

Serrapeptase has also been proven to be an alternative solution, supporting the body's natural response to inflammation and promoting the breakdown of dead tissues.

What Does Serrapeptase Do for Health?

Originating from the bacteria Serratia found in the intestines of silkworms, they bring great health benefits such as:

  • Reducing symptoms of ear, nose, and throat diseases: Studies evaluating the anti-inflammatory, local antifibrinolytic, and sputum-thinning effects of Serrapeptase help address local inflammation in patients, significantly reducing symptoms of ear, nose, and throat diseases [3].
  • Improving mucus and its viscosity in the respiratory system: Japanese studies conclude that the ability to reduce the amount of mucus and its viscosity secreted, as well as the number of neutrophils in the mucus significantly reduced, helping to reduce cough and prevent respiratory diseases [4].
  • Removing excess Fibrin: Serrapeptase helps heal the body's damaged tissues, retaining red blood cells and preventing oxygen from reaching the tissues, causing blood clots. Serrapeptase is proven to be able to cleanse, remove toxic waste in the blood, and reduce the threat of blood clot formation [5].
  • Supporting arthritis: Research has also proven the equivalent effectiveness of treating arthritis with enzymes compared to conventional drugs, improving pain symptoms in patients with arthritis [6].
  • Anti-venous inflammation: A study proves Serrapeptase helps reduce 63% spontaneous pain and 57% pain with pressure in patients with venous inflammation [7].

What Are Lumbrokinase?

what are lumbrokinase

Lumbrokinase is a type of fibrinolytic enzyme found in earthworm saliva, including Lumbricus bimastus and Lumbricus rubellus.

These enzymes are recognized as fibrinolytic agents, which can be used to treat various conditions related to thrombosis.

This enzyme was first discovered in 1991 by Dr. Mihara and scientists in Japan from the earthworm species Lumbricus rubellus and named collectively Lumbrokinase (LK) after the earthworm genus Lumbricus.

What Do Lumbrokinase Do for Health?

Similar to Serrapeptase, Lumbrokinase also brings many health benefits, most notably its mechanism of dissolving Fibrin and increasing the natural activity of t-PA to dissolve Fibrin clots.

In addition, it also helps reduce the whole blood viscosity and platelet aggregation without causing any side effects on the function of the nervous, respiratory, cardiovascular, liver, and kidney systems [8].

Moreover, Lumbrokinase has effects on preventing stroke due to local ischemia by reducing blood viscosity, preventing reperfusion injury, and minimizing possible defects in the nervous system [9].

Lumbrokinase is also being studied for other health effects such as preventing cancer [10], reducing chronic blood infections related to biofilms [11], improving diabetes-related kidney disease [12], preventing heart damage from smoke [13], promoting strong bone and new cell regeneration [14].

Are There Side Effects When Taking Serrapeptase and Lumbrokinase Together?

As mentioned above, there is currently little evidence to suggest that combining Serrapeptase and Lumbrokinase is safe or if they can cause any side effects.

This article can only provide some common symptoms experienced when using Serrapeptase or Lumbrokinase individually for you to be aware of and to exercise caution.

For Serrapeptase, it can cause conditions such as pneumonia in older adults due to a sudden decrease in white blood cells [15].

It may also lead to symptoms such as nausea, vomiting, stomach discomfort, cough, loss of appetite, muscle pain, joint pain, loss of appetite, and skin rashes.

Additionally, patients suffering from bleeding disorders should consult with a specialist before using Serrapeptase to not worsen bleeding or clotting conditions.

With Lumbrokinase, mild side effects may occur, including nausea, vomiting, black stools (stable hemoglobin levels), and dizziness [16]. Furthermore, it does not cause any other serious side effects.

How to Take Serrapeptase and Lumbrokinase Together?

how to take serrapeptase and lumbrokinase

Similar to the above, the safety of combining Serrapeptase and Lumbrokinase is uncertain.

You may use supplements containing a combination of Serrapeptase and Lumbrokinase, provided that reputable agencies approve the product and you consult a doctor for the most accurate advice based on your specific health condition.

However, according to research, the effective dosage of Serrapeptase is 10mg (equivalent to 20,000 FU), with a minimum of 5mg and a maximum of 60 mg depending on the health status and usage purpose.

The dosage for Lumbrokinase is 460-490 mg divided into three doses per day, continuously used from 2 weeks to 3 months without raising any health concerns. [17] [18].

The recommended dosage of Lumbrokinase is 460-490mg, divided into 3 doses throughout the day. It can be used continuously from 2 weeks to 3 months without raising any health concerns. [19].


Using Serrapeptase and Lumbrokinase offers significant health benefits, especially for cardiovascular health and the circulatory system. However, can you take Serrapeptase and Lumbrokinase together? The answer depends on many factors, and there's not much research on this issue. It is advisable to consult experts to ensure that usage is safe and suitable for you.


[1] Metkar, Sanjay Kisan, et al. “The Potential of Serratiopetidase and Lumbrokinase for the Degradation of Prion Peptide 106-126 - an in Vitro and in Silico Perspective.” CNS & Neurological Disorders Drug Targets, vol. 18, no. 9, 2019, pp. 723–731,, Accessed 14 May 2024.
[2] Metkar, Sanjay Kisan, et al. “The Potential of Lumbrokinase and Serratiopeptidase for the Degradation of Aβ 1-42 Peptide - an in Vitro and in Silico Approach.” The International Journal of Neuroscience, 27 June 2022, pp. 1–12,, Accessed 13 Nov. 2023.
[3] Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.
[4] Nakamura S, Hashimoto Y, Mikami M, et al. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003; 8(3):316-20.
[5] Prevent Heart Attack and Stroke with a Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, 2002.
[6] Klein G, Kullich W. Reducing pain by oral enzyme therapy in rheumatic diseases. Wien Med Wochenschr. 1999; 149(21-22):577-80.
[7] Bracale G, Selvetella L. Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase[Article in Italian] Minerva Cardioangiol. 1996; 44(10):515-24.
[8] Wang, Kevin Yueju, et al. “Recombinant Protein Production of Earthworm Lumbrokinase for Potential Antithrombotic Application.” Evidence-Based Complementary and Alternative Medicine, vol. 2013, 2013, pp. 1–8,
[9] Yang M, et al. Eisenia fetida lumbrokinase research VI – thrombolytic effect in rabbits and protective effects in experimental stroke model in hamsters. Biotechnology. 1995;5(3):9-11.
[10] De Cicco M. The prothrombotic state in cancer: pathogenic mechanisms. Crit Rev Oncol Hematol. 2004 Jun;50(3):187-96.
[11] Levi M, et al. Infection and inflammation and the coagulation system. Cardiovasc Res. 2003 Oct 15;60(1):26-39.
[12] Song WG, et al. Clinical observation of Boluoke with Lotensin, a new therapy for early stage diabetic nephropathy. Jiangxi Medical Journal. 2010 July; 45(7): 667-668.
[13] Liao HE, et al. Cardio Protective Effects of Lumbrokinase and Dilong on Second-Hand Smoke-Induced Apoptotic Signaling in the Heart of a Rat Model. Chin J Physiol. 2015 Jun 30;58(3):188-96.
[14] Fu YT, et al. Porous gelatin/tricalcium phosphate/genipin composites containing lumbrokinase for bone repair. Bone. 2015 Sep;78:15-22.
[15] 克己平原, et al. “セラペプターゼによる薬物性肺臓炎の1例.” 日本胸部疾患学会雑誌, vol. 27, no. 10, 1989, pp. 1231–1236,, Accessed 14 May 2024.
[16] Chen, Ying, et al. “Efficacy and Safety of Lumbrokinase plus Aspirin versus Aspirin Alone for Acute Ischemic Stroke (LUCENT): Study Protocol for a Multicenter Randomized Controlled Trial.” Trials, vol. 23, no. 1, 11 Apr. 2022,, Accessed 13 Nov. 2023.
[17] Yamaguchi T. Perspectives on enzyme products in the Japanese Pharmacopoeia. Presented at: USP Enzyme Workshop Meeting; July 8, 2009; Rockville, MD.
[18] Government of Canada, Health Canada. “Natural Health Products Ingredients Database.”, 26 July 2004, Accessed 11 May 2024.
[19] Agoncillo. “Meta-Analysis on the Safety and Efficacy of Lumbrokinase in Peripheral Arterial Disease.” Watermark.silverchair, Accessed 14 May 2024.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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