Bromelain Vs. Serrapeptase

Bromelain Vs. Serrapeptase: The Comprehensive Comparison

Bromelain and serrapeptase are two enzymes known for their anti-inflammatory and pain-relieving properties.

While bromelain is extracted from pineapples, serrapeptase is an enzyme produced by bacteria in the intestines of silkworms.

Both are widely used to treat inflammatory conditions, aid digestion, and improve various health issues.

This article comprehensively compares the two enzymes, helping you understand their uses, effectiveness, and how to use them.


Key Takeaways

  • Bromelain is a protease enzyme mixture extracted from the stems and fruit of the pineapple plant.
  • Bacteria in the intestines of silkworms produce Serrapeptase.
  • Both bromelain and serrapeptase have anti-inflammatory and digestive support properties.
  • Both enzymes can be used to treat post-surgical symptoms and other inflammatory conditions.
  • Using bromelain and serrapeptase together can enhance therapeutic effects.
  • Attention should be paid to dosage and timing when using both enzymes.

What is Bromelain?

Bromelain, extracted from the stems of pineapples

Bromelain, extracted from the stems of pineapples (Ananas comosus), possesses several biological properties, including promoting cell growth, circulation, and anti-inflammation [1].

Bromelain is a plant extract containing multiple active components whose proportions can vary based on soil conditions, climate, pineapple variety, and production process. These factors can affect the pharmacological activity of bromelain.

This enzyme breaks down proteins, helping to reduce inflammation, swelling, and pain. Bromelain is widely used in medicine to treat sinusitis and arthritis, particularly to reduce swelling and pain after surgery.

Main Benefits of Bromelain [2]:

  • Cardiovascular and Circulatory System: Bromelain helps relieve angina and transient ischemic attacks and is useful in preventing and treating thrombotic vein inflammation. It can also break down cholesterol plaques and has strong fibrinolytic activity, protecting muscles against ischemic and reperfusion injury.
  • Arthritis Relief: Bromelain can reduce pain and inflammation in arthritis, comparable to diclofenac, a nonsteroidal anti-inflammatory drug (NSAID). This makes bromelain a potential alternative to NSAIDs in treating arthritis.
  • Immune System: Bromelain is recommended as an adjunct treatment for chronic inflammatory diseases, cancer, and autoimmune diseases. It helps enhance immune response.
  • Clotting and Fibrinolysis: Bromelain increases fibrinolytic activity, prolongs clotting time, and helps prevent blood clots.
  • Diarrhea: Bromelain combats diarrhea-causing agents by preventing bacteria from adhering to the intestinal mucosa, reducing diarrhea symptoms.
  • Cancer: Bromelain reduces cancer cell growth and invasion, inhibits cancer-promoting factors, and helps reduce tumor growth.
  • Surgery: Bromelain reduces post-surgical pain and inflammation, helping decrease swelling, bruising, and pain after childbirth, and supports the treatment of acute inflammation and sports injuries.

What is Serrapeptase?

Serrapeptase, also known as serratiopeptidase

Serrapeptase, also known as serratiopeptidase, is a protease enzyme produced by the Serratia bacteria in the intestines of silkworms. Serratiopeptidase is an anti-inflammatory enzyme with numerous clinical applications, including production and treatment [3].

It has several significant therapeutic uses, such as anti-inflammatory effects, anti-biofilm formation, mucolytic activity, and synergistic effects with other medications.

Main Uses of Serrapeptase [3]:

  • Anti-inflammatory: Serrapeptase reduces inflammation by breaking down inflammatory proteins, thereby reducing swelling and pain.
  • Wound Healing: This enzyme helps dissolve dead tissue and improve microcirculation at the wound site, promoting faster healing.
  • Anti-biofilm Formation: Serrapeptase reduces bacterial adhesion, enhancing the effectiveness of antibiotics in treating biofilm-related infections.
  • Mucolytic Activity: The enzyme thins and decreases the viscosity of mucus, improving respiratory symptoms for patients with respiratory disorders, including COVID-19.
  • Fibrinolytic Activity: Serrapeptase can break down blood clots, helping to prevent and treat cardiovascular diseases caused by arterial blockages.
  • Synergistic Properties: When combined with antibiotics, serrapeptase enhances the drugs' effectiveness, helping to prevent biofilm formation and more effectively eliminate bacteria.
  • Anti-cancer: Some studies suggest that serrapeptase can inhibit the growth of cancer cells, particularly in the early stages of cancer.
  • Autoimmune Disease Treatment: This enzyme is also used in treating autoimmune diseases such as arthritis, helping to reduce inflammation and pain.

Bromelain Vs. Serrapeptase: Which Enzyme is Better?

Bromelain Vs. Serrapeptase: Which Enzyme is Better

Comparing bromelain and serrapeptase is not straightforward, as both enzymes have unique advantages. However, here are some key differences between the two:





Extracted from pineapples

Produced by bacteria in silkworm intestines


Bromelain is a protease enzyme that breaks down proteins, helping to reduce inflammation, swelling, and pain by breaking down proteins in the blood and damaged tissues.

Serrapeptase is also a protease enzyme that breaks down proteins, but it focuses on destroying scar tissue, blood clots, and mucus in the body.

Key Benefits

Reduces inflammation, aids digestion, enhances drug absorption

Reduces inflammation, breaks down dead tissue, aids wound healing


Treats sinusitis, arthritis, reduces post-surgical swelling

Treats arthritis, sinusitis, reduces post-surgical swelling

Suitable For

Better for those needing support with digestion, acute inflammation, sinusitis, and cancer treatment

Ideal for those dealing with chronic pain and inflammation, post-surgical and injury-related swelling, respiratory conditions needing mucus reduction, and cardiovascular health issues

Side Effects

May cause mild side effects like diarrhea, nausea, vomiting, and increased menstrual bleeding in some people. Avoid using bromelain if you are on blood thinners or allergic to pineapples.

Can cause side effects such as skin reactions, muscle and joint pain, weight loss, nausea, abdominal pain, cough, and blood clotting disorders. Should not be used with blood-thinning medications or supplements to avoid the risk of bleeding or bruising.

The comaprision table of Serrapeptase and Bromelain

Additionally, a study has shown that combining proteolytic enzymes such as trypsin, bromelain, and rutoside provides better control of postoperative sequelae compared to serratiopeptidase [4].

Can You Take Serrapeptase and Bromelain Together?

Research has shown that combining serrapeptase and bromelain may significantly benefit treating arthritis. These enzymes have anti-inflammatory and anti-swelling effects, which help reduce pain and improve inflammation [5].

However, more research is needed to determine the combined effects of these enzymes on our bodies.

Before combining these two enzymes, it is important to discuss them with a doctor or healthcare professional to ensure safety and effectiveness.

Moreover, both serrapeptase and bromelain have blood-thinning properties, so using them together may increase the risk of bleeding or bruising, especially if you are taking blood-thinning medications or other supplements with similar effects.

How to Take Serrapeptase and Bromelain Together?

When using serrapeptase and bromelain together, it is important to follow your doctor's advice or the manufacturer's instructions. Here are some guidelines for using these enzymes together:


  • The specific dosage of each enzyme depends on various factors such as health conditions, age, and purpose of use.
  • Typically, the common dosage of serrapeptase ranges from 10 to 60 mg per day, divided into multiple doses throughout the day [6].
  • Bromelain is usually taken in doses ranging from 80 to 320 mg daily, divided into multiple doses.


  • Generally, you should take serrapeptase and bromelain before meals, at least 30 minutes prior or as directed by your doctor.
  • They can be taken with water or other beverages.

Adjusting Dosage

  • Dosages can be adjusted based on the body's response and the doctor's guidance. Start with a lower dose to see how your body reacts.
  • Avoid exceeding the recommended dosage unless supervised by a doctor.

Adhering to Instructions

  • Always read the usage instructions carefully and consult a doctor or healthcare provider before starting any new medication or supplement.
  • Follow the prescribed directions and dosages strictly.

Monitoring Health

  • Monitor your health closely when using serrapeptase and bromelain to ensure no adverse reactions.
  • Remember that using serrapeptase and bromelain together, or any other supplements, requires supervision and advice from a doctor, especially if you have specific health conditions or are taking other medications.


Bromelain and serrapeptase are powerful enzymes with many health benefits, especially in reducing inflammation and pain after surgery.

Proper comparison and use of these enzymes can yield the best therapeutic outcomes.

We hope this article has provided a comprehensive understanding of bromelain and serrapeptase.


[1] Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. Journal of Ethnopharmacology. 1988;22(2):191-203. doi:
[2] Pavan R, Jain S, None Shraddha, Kumar A. Properties and Therapeutic Application of Bromelain: A Review. Biotechnology Research International. 2012;2012:1-6. doi:
[3] Nair SR, Subathra Devi. C. Serratiopeptidase: An integrated View of Multifaceted Therapeutic Enzyme. Biomolecules. 2022;12(10):1468-1468. doi:
[4] Raparthi Bhuvan Chandra, Kathiravan Selvarasu, Krishnan M. Comparison of Efficacy of Combination of Bromelain, Rutocide, and Trypsin With Serratiopeptidase on Postoperative Sequelae Following Mandibular Third Molar Surgery: A Randomized Clinical Trial. Curēus. Published online November 10, 2023. doi:
[5] Published 2014. Accessed May 23, 2024.
[6] Bhagat S, Agarwal M, Roy V. Serratiopeptidase: A systematic review of the existing evidence. International journal of surgery. 2013;11(3):209-217. doi:
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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