Can You Take Serrapeptase With Coffee

Can You Take Serrapeptase With Coffee?

Coffee is undoubtedly a favorite beverage for many of us, especially those who appreciate the alertness it brings to our productive hours. However, it also raises certain concerns for those intending to use coffee and other dietary supplements.

This article will delve into what happens when coffee is paired with serrapeptase - a dietary supplement supporting circulation and immunity - to answer the question: "Can You Take Serrapeptase With Coffee?"


Key Takeaways

  • Serrapeptase can help reduce inflammation and swelling and support various bodily functions.
  • Serrapeptase functions effectively when the caffeine has been metabolized and excreted via the excretion route.
  • Serrapeptase or other enzyme supplements should be taken 30 minutes before eating/drinking for optimal effectiveness.

Can You Take Serrapeptase With Coffee?

you shouldn't take serrapeptase and coffee together

Essentially, no direct scientific studies investigate the interaction between taking serrapeptase and coffee together.

However, neither is it explicitly advised for or against their combined use. However, I believe that their simultaneous use should be limited.

Firstly, Serrapeptase is an enzyme extracted from a bacterium called Serratia E15 [1]. It works by breaking down unnecessary proteins in the body, helping to reduce inflammation and swelling, and supporting various bodily functions.

As for coffee, it has low acidity and can stimulate users due to its caffeine content [2]. Because of these characteristics, it is often advised that coffee be consumed cautiously alongside medications or other pharmacologically active substances.

How Does Serrapeptase Work When Taking Coffee Together?

Serrapeptase is essentially an enzyme, so it's usually recommended to be taken 30 minutes before eating/drinking. This is to ensure that serrapeptase can function optimally in the body.

On the other hand, coffee contains a significant amount of caffeine. When absorbed into the bloodstream, caffeine inhibits the extracellular potassium concentration and hinders the activity of circulatory enzymes [3].

Although coffee may increase blood pressure and blood circulation speed, it will limit the action of other enzymes in the blood.

Thus, if both products above are used, serrapeptase does not entirely lose its efficacy but is largely restricted. Serrapeptase functions effectively when the caffeine has been metabolized and excreted via the excretion route.

Can You Drink After Taking Serrapeptase Supplements?

You might be thinking: If I can't drink coffee before taking serrapeptase, I can certainly drink it afterward, right? The answer to that question is: Yes, in principle, you can.

Because serrapeptase requires time to enter the body, and coffee also requires time, you can entirely take serrapeptase before your meal and drink coffee after a certain period, allowing serrapeptase enough time to be effective.

However, these two products can still affect each other as they move into the bloodstream, potentially rendering both activities less effective.

Therefore, if you're a coffee enthusiast, consider this to achieve optimal results.

How to Take Serrapeptase Effectively?

As mentioned above and through specific studies, serrapeptase or other enzyme supplements should be taken 30 minutes before eating/drinking for optimal effectiveness [4].

Therefore, the most effective time to take serrapeptase supplements is before meals.

Additionally, alcohol, beer, coffee, tea, or any other beverages have specific pharmacological properties and may have certain effects on the effectiveness of serrapeptase. Therefore, we still advise against using these products together.

Moreover, foods should also be carefully considered to avoid neutralizing/reducing the initial effects of serrapeptase. Some precautions to take before using serrapeptase will be addressed shortly.

Things You Need To Consider When Taking Serrapeptase Supplements

things to consider before taking serrapeptase supplements

Like many other products, serrapeptase can cause adverse effects when improperly combined.

To help us avoid undesirable consequences, this article will outline some precautions before using serrapeptase:

  • Studies have shown that serrapeptase shouldn't be taken with blood thinners like Warfarin and aspirin.
  • You should also avoid taking serrapeptase with dietary supplements like fish oil, garlic, turmeric, etc. These foods may increase your chances of bleeding or clotting and decrease the effectiveness of serrapeptase.
  • Serrapeptase may cause short-term side effects such as stomach pain, nausea, skin reactions, blood clotting disturbances, muscle and joint pain, poor appetite,...
  • These symptoms will soon disappear within a few days to a few weeks.
  • Finally, you should consult healthcare professionals for accurate and appropriate advice tailored to your body to avoid negative reactions from using serrapeptase.


In conclusion, Serrapeptase is a natural enzyme with significant potential health benefits.

However, when combined with coffee, its effectiveness may be diminished due to the impact of caffeine in the bloodstream.

Waiting at least 30 minutes after consuming serrapeptase before drinking coffee could be suitable for coffee enthusiasts.

If you aim to maximize the benefits of serrapeptase, remember to adhere to recommended dosages and usage guidelines and consult with healthcare professionals.

Focus on building a healthy lifestyle and consider all decisions regarding nutrition and health under the guidance of experienced experts. Your health should always be the top priority.


[1] Nakahama, Kazuo, et al. "Cloning and Sequencing of Serratia protease Gene." Nucleic Acids Research, vol. 14, no. 14, Jan. 1986, pp. 5843–55.
[2] Nehlig, Astrid. "Effects of Coffee/Caffeine on Brain Health and Disease: What Should I Tell My Patients?" Practical Neurology, vol. 16, no. 2, Dec. 2015, pp. 89–95.
[3] Sinclair, C. D., and Jonathan D. Geiger. "Caffeine Use in Sports. A Pharmacological Review." PubMed, vol. 40, no. 1, Mar. 2000, pp. 71–79.
[4] Careri, G., et al. "Statistical Time Events in Enzymes: A Physical Assessmen." CRC Critical Reviews in Biochemistry, vol. 3, no. 2, Jan. 1975, pp. 141–64.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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