Can Serrapeptase Help with Endometriosis

Can Serrapeptase Help with Endometriosis?

Serrapeptase is an enzyme from silkworms that reduces inflammation and breaks down scar tissue. This enzyme has many health benefits, including pain relief. Below, we'll explore how Serrapeptase affects endometriosis.


Key Takeaways

  • Serrapeptase may be beneficial for endometriosis, as supported by various studies.
  • Serrapeptase helps reduce inflammation, dissolve old scar tissue, decrease adhesions, and can be beneficial for cysts.
  • It should be taken on an empty stomach, usually 2 hours after eating.
  • Clinical studies and serrapeptase monographs suggest a dosage of 10 mg to 60 mg per day.
  • Pregnant and breastfeeding women, and those taking medications such as Warfarin, Clopidogrel, or Aspirin, or using natural remedies like garlic, fish oil, and turmeric, should avoid using serrapeptase.

Does Serrapeptase Help with Endometriosis?

Serrapeptase, also called serratiopeptidase, is a proteolytic enzyme from the bacterium Serratia E15, found in silkworms.

Research suggests it can help control or prevent endometriosis and fibroids by reducing inflammation. It also benefits heart and artery health [1].

What is Endometriosis and Its Symptoms?

What is Endometriosis

Endometriosis is when uterine tissue grows outside the uterus, causing pain, heavy periods, and infertility. In the past, doctors often thought endometriosis pain was psychological. Now, better research has led to improved management and prevention.

  • Common symptoms of endometriosis include [1]:
  • Painful periods (dysmenorrhea)
  • Pain during sex
  • Pain during urination or bowel movements, especially during menstruation
  • Heavy bleeding
  • Infertility

Other symptoms can include bloating, nausea, diarrhea, constipation, or fatigue, often during menstrual periods.

How Does Serrapeptase Help with Endometriosis?

Serrapeptase reduces inflammation, dissolves old scar tissue, and decreases adhesions and cysts. It breaks down fibrin, a protein involved in scar tissue formation.

Many women with endometriosis have painful periods, Serrapeptase may help by reducing inflammation and abnormal tissue [2].

Serrapeptase may also improve fertility in women with endometriosis by reducing inflammation and removing scar tissue and cysts, creating better conditions for fertilization and embryo development [3].

How to Take Serrapeptase for Endometriosis

ways to take serrapeptase for endometriosis

There are no specific guidelines for using Serrapeptase for endometriosis in studies.

Typically, Serrapeptase comes in capsules and should be taken on an empty stomach or at least two hours after eating. Wait about half an hour after taking it before eating again [2].

Follow the product label directions and don't exceed the recommended dosage.

Choose reputable products to ensure your health.

Serrapeptase Dosage for Endometriosis

The recommended dosage for managing endometriosis isn't specified. Clinical studies and the Serrapeptase monograph suggest doses from 10 mg to 60 mg per day [2].

Start with a low dose and gradually increase it, but always follow safe dosing or consult experts. Enzyme activity is measured in units; 10 mg of serratiopeptidase equals 20,000 units of enzyme activity [2].

What to Know When Taking Serrapeptase for Endometriosis?

Serrapeptase is a natural molecule that's been used for decades and is generally considered safe.

However, some studies have reported side effects like nausea and indigestion, though these are rare. These side effects might be dose-dependent or due to interactions with other medications.

If you're taking Warfarin, Clopidogrel, or Aspirin, or using natural remedies like garlic, fish oil, and turmeric, there may be a higher risk of bleeding or bruising when combined with Serrapeptase [2].

Pregnant or breastfeeding women should avoid using Serrapeptase because there isn't enough research on its safety for these groups.


Serrapeptase can help with endometriosis by reducing inflammation, relieving pain, and breaking down scar tissue. It can decrease chronic inflammation, menstrual pain, improve blood circulation, and potentially boost fertility. Although generally safe, it's important to follow the dosage instructions to avoid side effects.


[1] Redfern, Robert. Improving Endometriosis and Fibroids in 30 Days: Clear Endometriosis and Fibroids in 30 Days: Rehabilitation Plan for Long-Term Health. Google Books, NaturallyHealthyPublications, 29 May 2015, Accessed 15 May 2024.
[2] Bhagat, Shivani, et al. “Serratiopeptidase: A Systematic Review of the Existing Evidence.” International Journal of Surgery, vol. 11, no. 3, Apr. 2013, pp. 209–217,, Accessed 28 Nov. 2019.
[3] Sharma, J, et al. “Comparison of Ofloxacin & Ornidazole with Probiotic versus Doxycycline & Metronidazole for the Outpatient Treatment of Pelvic Inflammatory Disease.” JK SCIENCE, vol. 9, no. 2, 2007, Accessed 15 May 2024.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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