Rhodiola Vs. Bacopa

Rhodiola Vs. Bacopa: What are the Differences Between Them?

Rhodiola and Bacopa are always among the top adaptogens known for their remarkable health benefits. But what are the differences between them? With these differences in mind, how can we effectively combine these two herbs? This article will provide all the information about their differences, the mechanisms by which each herb works, and the most effective ways to combine them.

Before exploring further, please read the disclaimer located at the end of this webpage.

Key Takeaways

  • Adaptogens is a term used to describe herbs that primarily help maintain body balance and reduce stress.
  • Rhodiola is an adaptogen that effectively improves mental and physical performance and endurance.
  • Bacopa is an adaptogen known for enhancing brain function, supporting brain cells, and addressing memory issues related to aging.
  • Rhodiola and Bacopa can be combined, with dosage adjustments depending on individual purposes and needs.

What are Adaptogens?

what are adaptogens

Adaptogens is a term used to describe herbs that help the body maintain balance and adapt to stress. They work by regulating internal balance, increasing or decreasing biochemical reactions in the body, such as:

Balancing the HPA axis to regulate cortisol production, a stress hormone. [1]

Enhancing immune function through potential anti-inflammatory properties and cell protection via antioxidant properties.

Improving nervous system health. [1]

Adaptogens are often confused with nootropics, although their purposes differ:

Adaptogens enhance overall health and reduce stress, while nootropics focus on brain health and cognitive enhancement. Therefore, each nutritional supplement serves a distinct role depending on their intended use.

How does Rhodiola Rosea Work?

Mechanism of Action: Rhodiola, as an adaptogen, operates by impacting the HPA axis (the body's stress response system). This herb inhibits cortisol production, reducing stress and enhancing alertness under harsh environmental conditions such as high pressure, heat, and nutrient deficiency. [2]

Benefits of Rhodiola Rosea:
  • Enhances cognitive function and maintains alertness under challenging conditions [2].
  • Improves physical endurance and resilience [3].
  • Boosts adaptation and resilience to stress reduces fatigue and sustains mental and physical performance [3].

How Does Bacopa Work?

Mechanism of Action: The primary active compounds in Bacopa belong to a group called bacosides, readily found in the plant's leaves. These compounds play a crucial role in their biological effects on the human body, particularly on neurotransmitter systems in the brain. [4]

Benefits of Bacopa [4] [5]:

  • It enhances brain function and improves memory and learning ability.
  • Protects against brain cell aging and prevents neuro-related diseases.
  • Reduces inflammation in the body, along with having calming effects that alleviate stress on the nervous system.

Rhodiola Vs. Bacopa: What's the Difference Between Them?

What's the Difference Between Rhodiola and Bacopa


  • Rhodiola is predominantly found in high-altitude regions of Northern Europe, North America, and Asia.
  • Bacopa is primarily distributed in India, Southeast Asia, Sri Lanka, and Nepal (as an aquatic plant in wetland areas).

Regarding composition

  • Rhodiola contains three main compounds: salidroside, rosavin, and rosavin, alongside organic acids, polyphenols, and flavonoids. [8]
  • Bacopa mainly contains bacoside A and B and other compounds such as alkaloids, other flavonoids, and saponins. [7]

Mechanism of action:

  • Rhodiola acts on the nervous system and energy levels. [8]
  • Bacopa acts on the nervous system and cognitive function. [7]


Rhodiola helps improve mental and physical performance, boosts energy and endurance, and reduces stress. Because of this, Rhodiola is suitable for those who want to increase clean energy, keeping users alert without being overly stimulated.

Bacopa mainly focuses on improving memory and brain cell functions while also reducing anxiety. Unlike the energy-boosting function of Rhodiola, Bacopa has calming properties, supporting a peaceful mind.

Which Adaptogen is Better: Rhodiola Rosea vs Bacopa?

The choice between Rhodiola and Bacopa depends on individual conditions and needs. Rhodiola is an excellent choice if you're looking to enhance endurance and energy levels and reduce stress. However, prioritizing Bacopa would be advisable if your goal is to improve brain function and memory.

It's important to note that selecting either of these herbal supplements should be done under the supervision and advice of a healthcare professional or knowledgeable expert.

Can you Combine Rhodiola and Bacopa?

Rhodiola and Bacopa can be combined

Rhodiola and Bacopa can be combined. Some studies have used both adaptogens together without noting any side effects. Additionally, in traditional medicine, adaptogens are often combined within permitted dosages.

A study demonstrating the potential synergy of Rhodiola and Bacopa in an herbal complex found it effective in managing excessive daytime sleepiness [6].

The study involved 31 participants with this condition, divided into two groups: one receiving the herbal treatment and another receiving a placebo. The research spanned three weeks, during which participants were monitored and assessed before and after treatment.

Results indicated that both groups improved excessive daytime sleepiness after three weeks. However, the group receiving the herbal treatment containing a combination of Rhodiola, Bacopa, and two other plants exhibited a clearer trend of improvement compared to the placebo group.

How to Take Rhodiola and Bacopa Together?

To effectively combine Rhodiola and Bacopa, consider using individual doses with recommended amounts as follows:

For Rhodiola, the daily dosage ranges from 200-600 mg, standardized to 1% salidroside and 3% rosavins. It's best taken in the morning or early afternoon and avoided late in the day. [9]

For Bacopa, the daily dosage should be around 300mg, standardized to 50% bacosides. Bacopa can be taken any time during the day, but for optimal absorption, it's recommended to take it with meals.

Although safe to use, Rhodiola and Bacopa can cause some side effects when taken in excessive amounts, such as dizziness, dry mouth, or excessive saliva production.

Overdosing on Rhodiola can sometimes lead to insomnia due to its stimulating properties.

Alternatively, you can use functional products that combine ingredients from both herbs.

Things to Consider When Taking Rhodiola and Bacopa Together

Under the supervision of a doctor, consult for a reasonable combined dosage of Rhodiola and Bacopa.

Monitor the body closely and adjust the dosage if any side effects occur, especially ensuring not to exceed the recommended dosage.

Other Alternative Adaptogens You Can Choose

well-known adaptogens

In addition to well-known adaptogens like Rhodiola and Bacopa, you may also consider using other adaptogens such as Ashwagandha, Holy Basil, Ginseng, Schisandra, Cordyceps, Lingzhi, Maca, Turmeric, and others. These adaptogens offer similar benefits, so it's advisable to research and choose the ones that best suit your individual needs.


So, both Rhodiola and Bacopa have distinct characteristics and benefits. To enhance the brain's cognitive functions and balance stress, the best approach is to use a combination of these two herbs under the guidance of a doctor, who can advise on dosage and timing.


  • [1] Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress, Protective Activity, Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224. Published online 2010 Jan 19. doi: 10.3390/ph3010188
  • [2] Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. Author manuscript; available in PMC 2018 Dec 1.Published in final edited form as:Curr Pharmacol Rep. 2017 Dec; 3(6): 384–395. Published online 2017 Sep 14. doi: 10.1007/s40495-017-0106-1
  • [3] Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Date: 2018 https://www.sciencedirect.com/science/article/pii/S2095254616300345
  • [4] Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. Rejuvenation Res. 2013 Aug; 16(4): 313–326. doi: 10.1089/rej.2013.1431
  • [5] Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy - G K Shinomol 1, Muralidhara, Muchukunte M S Bharath. DOI: 10.2174/187221411794351833
  • [6] The efficacy of a herbal complex (Gingko biloba, Panax ginseng, Bacopa monerii and Rhodiola rosea) in the management of excessive daytime sleepiness.. Mazibuko, Sindisiwe Sthembile https://doi.org/10.51415/10321/3153
  • [7] Molecular and Functional Characterization of Bacopa monniera - A Retrospective Review, Evid Based Complement Alternat Med. 2015; 2015: 945217. Published online 2015 Aug 27. doi: 10.1155/2015/945217
  • [8] Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. A Panossian 1, G Wikman, J Sarris Affiliations. expand PMID: 20378318 DOI: 10.1016/j.phymed.2010.02.002
  • [9] Botanical Strategies for Migraines and Depression. http://cdn.naturaldispensary.com/downloads/Botanical_Strategies_for_Migraines_and_Depression.pdf
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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