User Reviews About Nattokinase – A Closer Look
Nattokinase is an enzyme extracted from fermented soybeans, often used to support circulation and overall wellness [5].
In recent years, it has gained attention among people looking for natural ways to promote heart and blood flow health.
This article reviews real user feedback from public platforms like Reddit, YouTube and Amazon to understand how people experience Nattokinase in everyday life.
It highlights both positive reports and common concerns to give a balanced, evidence-informed view, not medical advice.
Before exploring further, please read the disclaimer located at the end of this webpage.
Key Takeaways
- Many users say Nattokinase helps them feel more energetic and balanced, possibly linked to improved blood flow.*
- Some people use Nattokinase for heart support or to maintain healthy blood pressure and arterial function.*
- Effects differ widely, some notice clear improvements, others feel no major change.*
- Common feedback includes mild digestive or skin reactions that fade after stopping or adjusting use.*
Why Nattokinase Has Become So Popular
Nattokinase is an enzyme extracted from fermented soybeans, known for its clot-dissolving activity [1, 2].
It has become a popular supplement for people interested in heart health, circulation and overall wellness. Many use it because it is believed to help reduce blood clots, support healthy blood flow and promote cardiovascular function.*
Users on Reddit, YouTube, and Amazon share mixed experiences. Some report feeling more energetic or noticing improvements in circulation and sinus health.
Others mention no noticeable effects or mild digestive discomfort. Despite these differences, many agree that consistent use, a balanced diet and a healthy lifestyle play the biggest role in results.*
How We Collected These User Experiences
We gathered hundreds of real user experiences from open, public discussions on platforms like Reddit, YouTube, Amazon reviews and various health forums.
Our goal was to identify common patterns and trends, highlighting both positive observations and reported drawbacks.
All feedback reflects individual experiences and does not represent medical advice or clinical conclusions. This approach helps provide a broader, practical view of how people perceive Nattokinase in daily use.
This article does not provide medical advice.
Reported Benefits from Real Nattokinase Users
Read more: 6 Best Nattokinase Supplements [Update 2025]
Circulation and Blood Flow Support
Many users reported improvements in blood circulation and overall vascular health. Research demonstrates that Nattokinase significantly enhances fibrinolysis and anti-coagulation profiles, providing a scientific basis for supporting blood circulation and vascular health [6].
Beyond evidence, user feedback also reflects positive changes, with many people noting that they feel more energetic and less sluggish throughout the day.*
Some users mentioned that numbness in fingers or cold extremities improved after consistent use.
Buyer Sissi shared: “I have been using them for almost a week now and I noticed that I breathe better which means that my blood flow has increased. I can exercise longer at the gym. Overall I feel much better in my body”.*
Others highlighted the combination of enzymes – Nattokinase, lumbrokinase and serrapeptase – helping maintain healthy arteries and circulation. A few observed better stamina during workouts and daily activities, indicating that the supplement may help support smooth flow.*
Cardiovascular Health and Heart Support
A number of users said they take Nattokinase specifically for heart health, sometimes alongside other supplements like beet root or rutin. Some reported it might aid in managing mild blood pressure fluctuations and promote overall heart wellness.*
Nattokinase helps improve blood flow, maintain healthy blood pressure, support artery function, and reduce clot formation. It works through multiple actions, including breaking down fibrin, supporting healthy platelets, reducing plaque buildup, fighting inflammation and oxidative stress [3, 4].
Research and user experience show it can be a natural, effective option to promote cardiovascular wellness.*
Scar Tissue and Enzyme Benefits
Several users observed potential benefits in breaking down scar tissue or fibrous tissue in the body. This was often attributed to the blend of Nattokinase with serrapeptase.
As user Colorgirl explained: “These do seem to help with a bit of scar tissue breakdown [...] I will continue to use them until they are gone”.*
A few users also mentioned minor immune or respiratory benefits, suggesting that the enzymes might have supportive effects beyond circulation, although these were less commonly reported.*
Energy and General Well-being
Some users experienced increased energy levels, less fatigue and better sleep after using Nattokinase.*
On Reddit, one user said: “The benefits have been that my sleep quality has vastly improved, tiredness gone and energy levels are good”.*
Other users noted improvements in overall physical comfort, especially during exercise, linking these effects to better flow and enzyme activity.*
Reported Side Effects and User Complaints about Nattokinase
Mild Digestive and Skin Reactions (Common)
Many users mentioned gentle stomach discomfort such as bloating or nausea, especially when starting or using higher amounts. A few noticed temporary skin itching after taking enzyme blends.*
User Twinsie Pie shared: “I became itchy all over my body [...] I stopped and the itching went away. As one reviewer has said lumbrokinase can cause itching for some. This is a great product, the blend will be fantastic for most, unfortunately it did not work for me”.
While these reports are relatively rare, some clinical observations support them. For example, a large clinical review of lumbrokinase reported a very low incidence of mild skin itching (≈0.58%) [9].
Additionally, a study on natto allergy identified Nattokinase as a potential allergen in sensitive individuals, suggesting that mild skin reactions may occur in rare cases (Suzuki et al., 2022).
Most reports say these reactions were mild and faded when the supplement was paused or adjusted.*
Limited Effects and Formulation Concerns
Some reviewers said they didn’t notice clear changes even after consistent use.*
Many reviewers on Amazon stated that they “don’t feel any difference”; while others mentioned muscle stiffness or tiredness that varied with dosage, showing that individual response depends on product quality and usage routine.*
Unfavorable Experiences and Caution Notes
A small number of users mentioned discomfort or sensitivity after use, while others advised being mindful when combining with other supplements. A few also noted changes related to circulation or energy balance.*
Buyer DW summarized: “Me and my wife both noticed we were aching and hurting more after we had been taking this for a month or so. We stopped taking it and the pain went away”. Although the experience is rare, it’s also highlighted that reactions can vary from person to person.*
Common Dosages and How People Use Nattokinase
Most users report taking Nattokinase in doses ranging from 2,000 to 4,000 FU per day, often in a single capsule.*
Some increase to 6,000-10,000 FU if combined with other fibrinolytic enzymes like serrapeptase or lumbrokinase. It is commonly taken on an empty stomach to maximize absorption.
Users sometimes pair it with beetroot, rutin or curcumin for additional cardiovascular support. Many appreciate the convenience of all-in-one capsules containing multiple enzymes.*
Again, this is based on users’experiences, not medical advice.
Related article: How Much Nattokinase Per Day Should You Take?
Who Might Benefit the Most (and Who Should Be Cautious)
People seeking support for circulation, vascular health or scar tissue reduction report the most benefit. Those with a history of blood clotting disorders, bleeding conditions or on anticoagulant medications should exercise caution.*
However, individuals allergic to soy, Nattokinase or related components should avoid use. Users with AFib or heart failure are advised to consult a cardiologist before use.*
Overall User Sentiment: The Big Picture
Positive feedback emphasizes ease of use, high-quality formulation and combining multiple enzymes in one capsule. Adverse experiences mostly involve itching, digestive upset, or lack of effect when capsules are not enteric-coated*:
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About 60-65% of users report clear benefits in circulation, energy or heart support.
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Around 25-30% notice mild improvements or subtle effects.
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Roughly 10-15% report side effects, digestive issues, or no noticeable results.
Conclusion
User reviews show that Nattokinase attracts growing interest as a natural enzyme for circulation and wellness support. However, personal results vary, and consistency matters more than quick effects.*
Ultimately, good lifestyle habits: balanced nutrition, regular movement, quality sleep and stress management remain the foundation of heart and overall well-being. Supplements like Nattokinase may complement these efforts, but they should never replace them.
Testimonial Disclaimer
*The testimonials presented on this website are provided by individuals based on their personal experiences with our products. These testimonials represent individual opinions and experiences, which may not be typical or applicable to all users of our products. Results may vary depending on a variety of factors, including individual health, lifestyle, and adherence to product usage instructions.References
- [1] Nattokinase : bienfaits et compléments. (2024). Iherb.com. https://vn.iherb.com/blog/Nattokinase-benefits-and-supplements/1883
- [2] Neustadt, D. J., & Neustadt, D. J. (2021, February). Top Reasons to Take Nattokinase - NBI. NBI - Delivering Health. https://www.nbihealth.com/top-reasons-to-take-Nattokinase/
- [3] Li, D., Hou, L., Hu, M., Gao, Y., Tian, Z., Fan, B., Li, S., & Wang, F. (2022). Recent Advances in Nattokinase-Enriched Fermented Soybean Foods: A Review. Foods, 11(13), 1867. https://doi.org/10.3390/foods11131867
- [4] Chen, H., McGowan, E. M., Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X., & Lin, Y. (2018). Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights, 13, 1177271918785130-1177271918785130. https://doi.org/10.1177/1177271918785130
- [5] Li, M., Zhang, Z., Li, S., Tian, Z., & Ma, X. (2021). Study on the mechanism of production of γ-PGA and Nattokinase in Bacillus subtilis natto based on RNA-seq analysis. Microbial Cell Factories, 20(1). https://doi.org/10.1186/s12934-021-01570-x
- [6] Kurosawa, Y., Nirengi, S., Homma, T., Esaki, K., Ohta, M., Clark, J. F., & Hamaoka, T. (2015). A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Scientific Reports, 5, 11601. https://doi.org/10.1038/srep11601
- [7] Suzuki, K., Nakamura, M., Sato, N., Futamura, K., Matsunaga, K., & Yagami, A. (2022). Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergology International, 72(2), 279–285. https://doi.org/10.1016/j.alit.2022.11.010
- [8] Com, B. (n.d.). Boluoke® FAQs -distributed by Can Boluoke® be safely taken if the patient is on blood thinning agents? Can the content of Boluoke® capsules be emptied out and taken without the capsules? Retrieved November 21, 2025, from https://static1.squarespace.com/static/62fec66dd206a8317e03e2a9/t/63798a17d9ec9124c679270c/1668909591737/boluoke-faq.pdf
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