Why Should You Take Nattokinase On An Empty Stomach

Why Should You Take Nattokinase On An Empty Stomach?

Nattokinase, a natural enzyme found in Natto, a revered Japanese food for its health benefits, plays a vital role in personal health optimization. Optimal consumption of Nattokinase within nutrient-rich foods like Natto hinges on timing and method. Consuming Nattokinase on an empty stomach is recommended to harness its full health potential. This article delves into the scientific realm, addressing “Why should you take Nattokinase on an empty stomach”, exploring the advantages of this practice, and discussing its profound impact on personal wellness.


Why Should You Take Nattokinase On an Empty Stomach?

As previously mentioned, Nattokinase is an enzyme extracted from fermented soybeans in Japan, specifically from a dish known as Natto. 

Nattokinase is a protein-degrading enzyme that exhibits fibrinolytic solid activity, meaning it aids in breaking down proteins. Due to its ability to interact with proteins, consuming it with food might cause it to function similarly to a digestive enzyme. This could potentially diminish its health-improving effects. [1]

Research has indicated that consuming enzymes on an empty stomach aids the body's metabolic functions and significantly improves health [3]. Using Nattokinase in conjunction with other foods or consuming it when not hungry may diminish its effectiveness in improving health.

So, for maximum treatment effectiveness, taking Nattokinase on an empty stomach is advisable.

Is Nattokinase Absorbed In The Stomach?

There are misconceptions surrounding Nattokinase, often perceived as an enzyme that degrades in a stomach environment with a pH = 1. It is believed that the enzyme loses its health-supporting functions during digestion.

However, a study conducted at Machaon Diagnostics laboratory in the USA reveals that Nattokinase is resistant to gastric acid. Cardiovascular experts have found that the enzyme remains intact after passing through the digestive system and into the bloodstream. This resilience maximizes its effectiveness and reinforces its potential benefits. [2]

How To Take Nattokinase?

Taking Nattokinase From Natto

Natto is a nutrient-rich food containing ample vitamins and essential minerals. It can be consumed

  • Directly or heated
  • Pairs well with other foods like rice, eggs, and butter.

While consuming Natto directly for its nattokinase content can be effective, it might inconvenience some individuals due to its distinct smell and taste.

Additionally, Natto availability might be limited in certain areas, and consuming it daily might lead to monotony for some.

Furthermore, supplements containing nattokinase or functional foods can provide similar benefits. Research indicates that these alternatives are equally effective in achieving desired outcomes compared to direct Natto consumption.

taking nattokinase from natto

Taking Nattokinase Supplements With Or Without Food?

Nattokinase supplements offer flexibility in consumption, allowing intake with or without food. However, to maximize their potential health benefits, strategic timing is advisable.

For optimal effectiveness, it's recommended to take Nattokinase approximately 30 minutes before a meal or at least 1 hour after eating.

This specific timing ensures efficient absorption and utilization within the body. Pre-meal consumption initiates digestion for better absorption, while post-meal intake avoids potential nutrient interactions.

Adhering to this timing aims to efficiently enhance Nattokinase's fibrinolytic activity and other health-supporting effects.

Individual responses vary; hence, consulting healthcare experts for the most suitable timing based on health conditions and medications is recommended.

Taking Nattokinase With Other Supplements

Combining Nattokinase with other supplements is highly feasible. For instance, the synergy of Nattokinase, Serrapeptase, and Lumbrokinase can contribute to:

  • Maintaining a healthy cardiovascular function.
  • Supporting efficient circulatory systems
  • Immune Support
  • Antioxidant Support

However, prioritizing your safety is crucial. It is recommended that you consult a healthcare professional to discuss your specific condition and health improvement needs.

This consultation will help determine the appropriate dosage and optimize the usage of Nattokinase With Other Supplements tailored to enhance your overall well-being.

taking nattokinase from supplements

Precautions When Using Nattokinase

Avoid nattokinase if you have a severe allergy to it or any components (part or ingredient) that make up its Nattokinase supplement. You'll also want to avoid Natto if you have a soybean allergy.

Pregnant or breastfeeding women, children, and adults over 65 should use Nattokinase with caution as there's limited information regarding its long-term safety for these groups.

Individuals with blood disorders should only use Nattokinase with medical guidance.


The numerous health benefits of Nattokinase make it an invaluable asset in the realm of nutritional supplements. Strategic consumption notably enhances its effectiveness. For optimal absorption and utilization, it is advisable to take Nattokinase on an empty stomach. This ensures maximum efficacy and promotes a variety of health-supporting effects. However, individual responses may vary, and it is essential to consult a healthcare professional for personalized advice. As ongoing research uncovers the potential of this enzyme, it becomes clear that Nattokinase offers promising opportunities for personal health optimization.


[1] Jamali, N., Vahedi, F., Soltani Fard, E., Taheri-Anganeh, M., Taghvimi, S., Khatami, S. H., Ghasemi, H., & Movahedpour, A. (2023). Nattokinase: Structure, applications and sources. Biocatalysis and Agricultural Biotechnology, 47, 102564. https://doi.org/10.1016/j.bcab.2022.102564
[2] Jensen, G., Lenninger, M., Ero, M. P., & Benson, K. (2016). Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integrated Blood Pressure Control, Volume 9, 95–104. https://doi.org/10.2147/ibpc.s99553
[3] Kaur, R., & Sekhon, B. S. (2012). Enzymes as drugs: an overview. Journal of Pharmaceutical Education & Research, 3(2).
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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