Nattokinase And Vitamin K2

Nattokinase And Vitamin K2: Are They The Same Thing?

Nattokinase and Vitamin K2 are essential substances in Natto, a traditional Japanese food known for its health benefits. While they come from the same source, they have distinct functions and effects on health. In this article, we'll explore the relationship between Nattokinase and Vitamin K2, discussing their differences, the removal of Vitamin K2 from Nattokinase, their content in Natto, and dietary considerations and potential interactions with other supplements. This content will provide a comprehensive understanding of Nattokinase and Vitamin K2 to make informed choices about their use.


Is Nattokinase The Same As Vitamin K2?

Nattokinase and Vitamin K2 are not the same. They are both components of Natto but have different roles and benefits for human health.

Nattokinase, a potent fibrinolytic enzyme produced during the fermentation process of Natto, is known for its potential ability to dissolve blood clots, regulate lipid composition, and decrease the risk of heart diseases and arterial plaque [1, 3].

On the other hand, Vitamin K2, particularly its form Menaquinone-7, found abundantly in Natto, plays a vital role in blood clotting and maintaining optimal bone health, potentially helping prevent osteoporosis [4].

It's important to note that while they are derived from the same food source, their bodily functions are unique and complementary.

The Relationship Of Vitamin K2 And Nattokinase?

While nattokinase and vitamin K2 originate from Natto, their relationship is more synergistic than intertwined.

Nattokinase, an enzyme, explicitly targets fibrin, a protein in blood clotting. It helps maintain proper blood flow, thus promoting heart health.

Vitamin K2 is a nutrient that helps blood clotting, but unlike nattokinase, it doesn't break down existing clots - instead, it helps prevent excessive clotting by regulating certain clotting factors.

Ultimately, both nattokinase and vitamin K2 contribute to blood health, but they do so through distinct pathways.

benefits of nattokinase and vitamin k2 for blood health

Why Is Vitamin K2 Removed From Nattokinase?

Despite both originating from Natto and playing an essential role in blood health, Vitamin K2 is typically removed from Nattokinase supplements due to their conflicting effects on blood clotting.

Vitamin K2 aids in clot formation, a necessary process to prevent excessive bleeding during injury. In contrast, Nattokinase has the remarkable capability to dissolve existing blood clots, thereby enhancing the flow of healthy blood and potentially mitigating the risk of heart-related complications.

Keeping both in the same supplement could negate each other's effects, creating confusion for the body's clotting mechanism. Therefore, Vitamin K2 is often separated from Nattokinase in dietary supplement formulations to ensure efficacy.

Does Nattokinase Contain Vitamin K2?

Nattokinase supplements do not contain Vitamin K2. While Nattokinase and Vitamin K2 coexist in their natural source, Natto and products fermented with B.subtilis [2] are separated during the manufacturing process of Nattokinase supplements.

This is primarily to prevent their conflicting effects on blood clotting. However, if you consume Natto directly, you can ingest both Nattokinase and Vitamin K2. It's worth noting that the quantity of Vitamin K2 can vary in different Natto products, so it is recommended to check the nutritional information if you are specifically seeking this vitamin.

How Much Vitamin K2 Is In Natto?

Natto, a nutritional powerhouse, is particularly rich in Vitamin K2. It stands out as one of the most abundant sources of this essential nutrient.

The actual Vitamin K2 content may vary due to factors such as the fermentation process. However, it has been reported that Natto contains over 880 mg of Vitamin K2 per 100g [4]. This remarkable concentration makes Natto an excellent choice for individuals seeking to enhance their Vitamin K2 intake.

Can I Take Vitamin K2 With Nattokinase?

Limited studies suggest that Vitamin K2 may enhance the lipid composition-altering effects of Nattokinase, but it does not influence arterial plaque markers [3].

However, as Vitamin K2 aids in clotting and Nattokinase helps dissolve clots, the combination could confuse the body's clotting mechanisms.

Considering individual health conditions and needs is crucial before taking these together.

What Supplements Should Not Be Taken With Nattokinase?

While no formal research exists on which supplements should not be taken with Nattokinase, it's essential to exercise caution based on user feedback and known interactions. Certain supplements such as Vitamin K2, aspirin, and ginkgo may interact with Nattokinase due to their effects on blood clotting.

Keep in mind that these are general suggestions, and interactions may vary. It's always wise to get advice from a healthcare professional before starting any new supplement.

Aspirin should not be taken with Nattokinase

What Should Vitamin K2 Not Be Taken With?

Caution should be exercised when using Vitamin K2 with certain medications, as they may interfere with its effectiveness. The medicines include antacids, blood thinners, antibiotics, aspirin, and drugs prescribed for cancer, seizures, high cholesterol, and various other conditions.


Nattokinase and Vitamin K2 found in Natto play unique and crucial roles in our health. While they originate from the same source, their functions differ significantly, leading to their separation in dietary supplements. This separation ensures that each can function without interfering with the other. When considering these supplements, it's essential to consider individual health conditions and potential interactions and always seek advice from a healthcare professional.


[1] Gasmi, A., Bjørklund, G., Peana, M., Mujawdiya, P. K., Pivina, L., Ongenae, A., Piscopo, S., & Severin, B. (2021). Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation. Critical Reviews in Food Science and Nutrition, 62(25), 7062–7071.
[2] Wang, H., Liu, H., Wang, L., Zhao, G., Tang, H., Sun, X., Ni, W., Yang, Q., Wang, P., & Zheng, Z. (2019). Improvement of menaquinone-7 production by Bacillus subtilis natto in a novel residue-free medium by increasing the redox potential. Applied Microbiology and Biotechnology, 103(18), 7519–7535.
[3] Xu, B., Xu, B., Provincial People's Hospital, S., Guo, C., & Lin, Y. (2022). 
[4] Yanagisawa, Y., & Sumi, H. (2005). Natto Bacillus Contains A Large Amount Of Water-Soluble Vitamin K (Menaquinone-7). Journal of Food Biochemistry, 29(3), 267–277.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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