nac bromelain and nattokinase

Can You Take NAC Nattokinase and Bromelain Together?

Nattokinase, Bromelain, and NAC are three popular substances that improve our health. However, whether using them together is safe and effective remains a question of concern.

By delving into the mechanisms of action of each substance and their interactions, we will gain a comprehensive overview and more precise understanding of the use of these three dietary supplements.

This article will help answer this question and provide some considerations when using these three types of dietary supplements.

Key Takeaways

  • Some studies have indicated that Nattokinase, Bromelain, and NAC can be safely and effectively used together in certain cases.
  • Combining Nattokinase, Bromelain, and NAC can bring about significant health benefits.
  • Some potential side effects may occur when combining Nattokinase, Bromelain, and NAC.
  • Determining the appropriate dosage and usage regimen is crucial when combining these supplements.

Can You Take Nattokinase, Bromelain and NAC Together?

Research has demonstrated favorable outcomes when both Bromelain and Acetylcysteine are used together [4].

However, as of now, Nattokinase has only been found to potentially interact with certain cardiovascular drugs [5].

Therefore, while Nattokinase, Bromelain, and NAC each possess distinct biological activities, they may synergize when used together.

However, before starting this combination, be sure to discuss it with a doctor or healthcare professional to ensure safety.

Nattokinase is an important enzyme produced from natto

Nattokinase is an important enzyme produced from the bacterium Bacillus subtilis natto.

This enzyme can directly break down fibrin and remains stable in the digestive tract, making it suitable for oral thrombolytic therapy.

NK is also considered a valuable nutritional supplement, with safety and ease of large-scale production [1].

Additionally, Nattokinase has applications in treating hypertension, Alzheimer's disease, and vitreoretinal disorders.

Bromelain is a crude extract from the stem and fruit of pineapple

Bromelain is a crude extract from the stem and fruit of pineapple, consisting of a mixture of enzymes and other components such as phosphatase, glucosidase, and cellulase.

Bromelain exhibits multiple enzyme activities with a pH range from 5.5 to 8.0 and is produced from fresh pineapple juice through filtration and drying methods [2].

Bromelain functions by selectively inhibiting the synthesis of pro-inflammatory prostaglandins and possessing analgesic and antibacterial properties.

NAC (N-Acetyl Cysteine), or Acetylcysteine, is a cysteine derivative used as a nutritional supplement. NAC has potent antioxidant and anti-inflammatory properties, helping to maintain cellular redox balance [3].

NAC is a cysteine derivative used as a nutritional supplement

Adequate intake of cysteine and NAC plays a crucial role in maintaining health and replenishing glutathione, one of the body's most powerful antioxidants.

These amino acids may also support the treatment of chronic respiratory issues, improve reproductive function, and promote brain health.

How Do Nattokinase, Bromelain, and NAC Work Together?

Nattokinase has blood-thinning properties, Bromelain possesses anti-inflammatory characteristics, and NAC may support inflammation reduction and detoxification. When combined, they can synergize and provide health benefits.

Enhanced anti-inflammatory activity: Bromelain [6] and NAC [7] can reduce inflammation and alleviate pain. When combined with Nattokinase, their synergistic effect may enhance overall anti-inflammatory activity.

Support for the circulatory system: Nattokinase is known for reducing blood clotting and improving blood circulation. The combination of Bromelain and NAC can enhance this effectiveness by reducing inflammation and improving vascular function.

Digestive support: Bromelain aids in protein digestion and reduces intestinal inflammation, while NAC helps reduce inflammation and protect the digestive mucosa.

Combined with Nattokinase, they may collectively support the digestive process and nutrient absorption.

Benefits When Combining Nattokinase, Bromelain, and NAC

combine Nattokinase, Bromelain, and NAC

When combined, Nattokinase, Bromelain, and NAC may provide the following benefits:

  • Cardiovascular support: Nattokinase can help reduce blood clotting and improve blood circulation, while Bromelain and NAC have anti-inflammatory properties and can enhance vascular function. The combination of these three compounds may collectively support cardiovascular health.
  • Inflammation and pain reduction: Both Bromelain and NAC exhibit anti-inflammatory and pain-relieving properties. When combined, they may synergistically reduce inflammation and alleviate pain symptoms.
  • Digestive support: Bromelain aids in protein digestion and reduces intestinal inflammation, while NAC helps protect the digestive mucosa. Combined with Nattokinase, they may support digestion and nutrient absorption.
  • Improved blood circulation: Nattokinase can help reduce blood clotting and improve blood circulation in the body, facilitating the delivery of nutrients and oxygen to cells.
  • Cellular protection: NAC is a potent antioxidant that can protect cells from damage caused by free radicals.

Side Effects May Happen When Using This Combine

Although rare, using this combination may cause adverse effects such as digestive disturbances or allergic reactions in some individuals:

  • Digestive disorders: Bromelain may cause mild side effects such as diarrhea, nausea, vomiting, and heavier-than-normal menstrual bleeding in some individuals, especially when taken at high doses.
  • Increased risk of bleeding: It's also advisable to avoid using Bromelain and Nattokinase if you're taking blood thinners like Warfarin, as they may increase the risk of excessive bleeding.
  • Allergic reactions: Bromelain should not be used by individuals allergic to pineapple or substances with potential cross-reactivity, such as grass pollen, latex, celery, fennel, carrots, and wheat.
  • Drug interactions: There may be interactions between the components in this combination and other medications you're taking. Therefore, it's important to discuss with your doctor or pharmacist about any potential drug interactions.

If you experience any adverse symptoms while using this combination, stop immediately and seek guidance and treatment from a doctor or healthcare center.

Things Need to Consider When Taking Nattokinase, Bromelain, and NAC

Just like with any supplement we introduce into our bodies, it's essential to plan and understand how to use it safely and effectively.

Therefore, when using the combination of Nattokinase, Bromelain, and NAC, there are several things to consider:

  • Dosage: Adhere to the recommended dosage for each component. Overdosing can lead to unwanted side effects.
  • Drug interactions: Discuss with your doctor or healthcare professional if you are taking any other medications.
  • Health conditions: Consult with your doctor before using this combination if you have any health issues, exceptionally high blood pressure, digestive issues, or bleeding disorders. Because using Nattokinase may have implications for cardiovascular health.
  • Allergic reactions: Monitor carefully for signs of allergic reactions after starting this combination, and stop using and consult with your doctor if any signs of allergic reactions occur.
  • Product quality: Choose products from reputable and certified manufacturers to ensure product quality and safety. Currently, many counterfeit products are on the market, so to avoid "losing money and losing goods," choose products from reputable sources.
  • Duration of use: Determine the duration of using this combination based on the guidance of your doctor or healthcare professional. Each type will be designed for specific usage hours; consider the instructions on the products for particular times.


In summary, we can conclude that using Nattokinase, Bromelain, and NAC together can bring significant health benefits, including improving blood circulation, reducing inflammation, and supporting immune function.

However, this can also cause some side effects and unwanted interactions, especially when combined with other medications. It's important to ensure they suit your current health condition.

Before using any supplements, consult with your doctor or healthcare professional first.


[1] Dabbagh F, Manica Negahdaripour, Aydin Berenjian, et al. Nattokinase: production and application. Applied microbiology and biotechnology. 2014;98(22):9199-9206. doi:
‌[2] Pavan R, Jain S, Shraddha, Kumar A. Properties and Therapeutic Application of Bromelain: A Review. Biotechnology Research International. 2012;2012:1-6. doi:
‌[3] Cristina, Nayara Gomes Graciliano, Fabiana Andréa Moura, Cabral A, Oliveira M. N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants. 2021;10(6):967-967. doi:
‌[4] (A) Bromelain and Acetylcysteine present a synergistic effect on severe... ResearchGate. Published 2021. Accessed May 9, 2024.
‌[5] Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker insights. 2018;13:117727191878513-117727191878513. doi:
‌[6] Fitzhugh DJ, Shan S, Dewhirst MW, Hale LP. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clinical immunology. 2008;128(1):66-74. doi:
‌[7] Queiroz K, Fabiana Andréa Moura, Marques J, Roberto O, Célia J, Oliveira M. Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine. International journal of molecular sciences. 2015;16(12):30269-30308. doi:
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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