Benefits of Nattokinase for Cardiovascular Health

What are the Benefits of Nattokinase for Cardiovascular Health?

For humans, the heart serves as the engine driving the entire body. Therefore, maintaining a healthy cardiovascular system is a top priority in healthcare.

In the quest for cardiovascular support products, many have come across Nattokinase and its purported effects.

This article delves into various aspects to help understand the role of Nattokinase in cardiovascular health.


Key Takeaways

  • A potent active compound found in Natto, Nattokinase, has effects such as fibrinolysis, blood pressure reduction, anti-atherosclerosis, lipid-lowering, anti-platelet, and neuroprotective properties.
  • Some opinions suggest that Natto's effects on atrial fibrillation (afib) are not conclusively proven.
  • Nattokinase aids in clearing blood clots and increasing blood flow rate throughout the body.
  • Some individuals may experience side effects when using Nattokinase.

What are the Benefits of Nattokinase for Cardiovascular Health?

Nattokinase is derived from fermented soybeans and is believed to offer various health benefits, including those related to heart health.

Numerous studies and real-world experiments have demonstrated that Nattokinase offers positive effects on cardiovascular health.

Recent research has shown that NK - one of the most potent compounds in Natto - has effects such as fibrinolysis, blood pressure reduction, anti-atherosclerosis, lipid-lowering, anti-platelet, and neuroprotective properties [1].

Some viewpoints also suggest that Nattokinase may positively influence complex cardiovascular conditions, such as its dosage on afib - a relatively common cardiac arrhythmia.

On one hand, it is believed that Nattokinase's blood pressure-regulating ability may alleviate AFib symptoms. On the other hand, some argue that Natto's effects on afib are not conclusively proven.

The Mechanism of Nattokinase on Cardiovascular Health

Mechanism of Nattokinase on Cardiovascular Health

Specifically, the mechanism is relatively straightforward. When Nattokinase is introduced into the body through any means, it is absorbed, and its compounds quickly enter the bloodstream.

With its fibrinolytic ability, Nattokinase rapidly dissolves blood clots and increases the blood flow rate per second in the body [2]. This action helps clear the blood pathways, preventing atherosclerosis or blood fat accumulation.

Additionally, regulating blood circulation in the body helps maintain blood pressure and reduces palpitation or anxiety-related irregularities. A study has shown that after 6 months of usage, the blood lipid levels of test subjects were stabilized [3].

All scientific studies have demonstrated that Nattokinase can be a valuable ally in addressing cardiovascular issues.

Side Effects May Happen When Taking Nattokinase for Cardiovascular Health

While generally safe and rarely causing side effects within 6 months of usage, some individuals may experience mild symptoms when using Nattokinase, such as:

  • Digestive disorders
  • Allergic reactions in sensitive individuals
  • It may exacerbate bleeding when combined with blood thinners.
  • ...

Therefore, when using Nattokinase or Nattokinase supplements to improve cardiovascular health, exercise caution and seek medical assistance promptly if experiencing any unusual symptoms!

How to Use Nattokinase for Heart and Cardiovascular Health

Today, there are several ways to harness the benefits of Nattokinase for heart health, which you can explore and choose from:

  • Direct intake through a Nattokinase-rich diet is the quickest and easiest way. However, picky eaters may face a hurdle due to Natto's distinctive flavor.
  • Due to its unique taste, there are now various Nattokinase supplements available. Among the safest are Nattokinase capsules, which are convenient and widely purchasable.
  • Don't forget to adhere to recommended dosage guidelines and monitor your response to Nattokinase, adjusting the dosage as needed based on your condition.

Although these products are relatively safe, consulting experts in the field can help you choose the most suitable product for you!

Other Benefits of Nattokinase for Human Health

Other Benefits of Nattokinase for Human Health

In addition to its cardiovascular benefits, Nattokinase has numerous other positive effects on our bodies, including:

  • Skin Beauty: Nattokinase promotes collagen synthesis [4] and pigment synthesis [5], leading to smooth, fair, less wrinkled skin. Natto is indeed one of the beauty secrets of Japanese women!
  • Joint Support: Some studies suggest that Nattokinase's anti-inflammatory properties may be particularly beneficial for joint health and flexibility.
  • Digestive Health: Due to its probiotic content, Natto may support gut health, reduce symptoms such as bloating, indigestion, and diarrhea, and enhance nutrient absorption.

Other Ways to Improve Your Cardiovascular Health

Apart from Nattokinase, there are many other paths to improving cardiovascular health, which you can start today for a healthier tomorrow:

  • Adopting a balanced diet rich in fruits, vegetables, whole grains, and proteins. A healthy diet helps mitigate unwanted health issues.
  • Regular physical exercise is essential for a healthy heart. Not only your muscles but also your heart needs exercise!
  • Managing stress through relaxation techniques, mindfulness, and ensuring good sleep quality.
  • Limiting alcohol, tobacco, and especially stimulants.

With these solutions, it is hoped that you will have a healthy body and never have to worry about illnesses again.


In conclusion, research has demonstrated that Nattokinase positively affects cardiovascular health, alleviating symptoms such as high blood pressure, palpitations, atherosclerosis, or blood vessel blockages through its fibrinolytic action and blood circulation regulation.

The effects of Nattokinase on afib are still not entirely proven. Nattokinase can be supplemented in various ways and may entail minor side effects.

Therefore, before using Nattokinase supplements, conduct thorough research and seek expert advice for safe usage. Lastly, don't forget to adjust your diet or exercise routines to maintain a healthy heart!


[1] Chen, Hongjie, et al. “Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases.” Biomarker Insights, vol. 13, Jan. 2018, p. 117727191878513.
[2] Weng, Yunqi, et al. “Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease.” International Journal of Molecular Sciences, vol. 18, no. 3, Feb. 2017, p. 523.
[3] Li, Xinmin, et al. “Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials.” Reviews in Cardiovascular Medicine, vol. 24, no. 8, Aug. 2023, p. 234.
[4] Tokudome, Yoshihiro, et al. “Effects of Soybean Peptide and Collagen Peptide on Collagen Synthesis in Normal Human Dermal Fibroblasts.” International Journal of Food Sciences and Nutrition, vol. 63, no. 6, Jan. 2012, pp. 689–95.
[5] Ghazali, S. R., Danial Iylia, & Rozaini, M. Z. (2022). Determination of Chemical and Physical Properties of Soybean as Skin Care Product. International Journal of Synergy in Engineering and Technology, 3(1), 88-94. Retrieved from
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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