Does Nattokinase Benefit for Skin Health

Does Nattokinase Benefit for Skin Health?

It can be said that in the beauty care industry, the issue of nutrition and dietary supplements is no less important than skincare and makeup products. While cosmetics help improve the appearance of the skin, nutrition affects it from within.

Nattokinase, a compound extracted from fermented soybeans originating from Japan, has attracted attention as a Japanese skincare secret.

This article will explore the benefits of nattokinase for the skin and how it can benefit your skincare regimen.


Key Takeaways

  • Nattokinase mainly contains Isoflavone, a compound that enhances the production and synthesis of skin pigments.
  • Through collagen supplementation and synthesis mechanisms, Nattokinase helps slow down signs of wrinkles, sagging, dark circles, and other imperfections.
  • Nattokinase is believed to improve blood circulation and reduce blood clots and excess fat buildup in the blood vessels.
  • Additionally, Nattokinase has other effects on cardiovascular, digestion, and joint health, with diverse and suitable supplementation options for everyone.

Does Nattokinase Benefit for Skin Health?

soybean may promote collagen production for skin

Processed through a special Japanese fermentation method, Nattokinase or Natto is well-known for its versatility in our health. One of its benefits is its antioxidant effect - helping rejuvenate the skin, prevent aging, and provide smooth skin.

Moreover, due to its effects on circulation and blood flow systems and its ability to improve nutrition, Nattokinase enhances metabolic activity in skin cells, promoting healthy skin from within.

Furthermore, a group of enzymes called MMP found in soybean and Nattokinase also promotes collagen production - an important protein for maintaining firm and elastic skin without wrinkles or sagging [1]. However, there is still a debate about this function of Nattokinase, that is, whether or not an enzyme group called MMP is found in Nattokinase [2].

So, suppose it is true, combined with its anti-inflammatory properties. In that case, Nattokinase also helps the skin recover more quickly from surface damage. To better understand the benefits of Nattokinase for the skin, let's delve into its mechanism of action on the body!

How Does Nattokinase Benefit for Skin Health?

Isoflavone in soybean may promote the production of melanin skin pigments

Firstly, we know that soybeans are a widely consumed organic product. Soybeans contain up to 90% Isoflavone - a type of Genistein capable of brightening the skin through the melanin synthesis pathway and promoting the production of melanin skin pigments [3].

However, you also know that Nattokinase is a product derived from soybeans containing many beneficial bacteria and processed through fermentation. Due to this special processing method, Natto's nutrients are greatly enhanced [4].

Through this mechanism, Natto performs superior functions in synthesizing skin pigments and Collagen compared to its soybean origin.

In a trial with a Natto-based product, after 6 weeks of use, all test subjects showed impressive results in data and observations with the naked eye. Their skin became smoother and rosier, with positive reports of improvement in dark circles, wrinkles, sagging areas of the skin, etc. [5].

What are the Benefits of Nattokinase for Skin?

Promotes Skin Pigmentation

Nattokinase products or extracts from Natto mainly contain Isoflavone, a compound that enhances the process of producing and synthesizing skin pigments. After a period of use, Natto brings positive changes to the skin tone, making it fairer, rosier, more attractive, and alluring.

Aids in Collagen Synthesis

As mentioned above, Collagen is believed to be a vital component in slowing down the skin's aging process, especially for women [1]. Through collagen supplementation and synthesis mechanisms, Nattokinase helps slow down signs of wrinkles, sagging, dark circles, and other skin imperfections, which are common adversaries for women.

Enhances Blood Circulation & Nutrient Exchange

Nattokinase enhances blood circulation and reduces blood clot formation and excess fat buildup in the blood vessels in a short period [6].

Additionally, it contains beneficial bacteria for the gut. This improves metabolic activity and strengthens resistance against harmful factors, promoting better nutrient exchange among skin cells.

Combats Oxidative Stress

Lastly, one of Nattokinase's most significant and impressive effects is its antioxidant properties. As we know, many lifestyle-related disorders stem from oxidative stress-induced damage to living organisms.

Imbalances in antioxidant mechanisms lead to aging and loss of many cells, including skin cells.

Numerous experiments have concluded that Natto products increase the total content of phenolics, flavonoids, and isoflavones, which slow down the skin's aging process [7].

How Do Japanese Women Use Natto As Their Skin Health Supplements?

Japansese women use natto to improve their skin

Originally from Japan, Nattokinase is a traditional secret of Japanese women for their skin. Japanese women's fair skin is not just due to special makeup techniques but also their distinctive diet - one of which includes Nattokinase.

Nattokinase is a traditional and widely consumed food in Japanese cuisine, and they incorporate it into their meals very regularly. This dietary habit optimizes the benefits of Nattokinase for Japanese people.

However, maintaining this habit isn't easy, not because of establishing dietary habits but because of the taste of this food. Nattokinase is a fermented food, so its taste is unique, making it challenging for those unfamiliar with it to enjoy.

Furthermore, there are now many Nattokinase-based supplement products that Japanese people trust. These products, available in pill form or as diluted powders, seem more user-friendly for most consumers.

How to Use Nattokinase Supplements for Skin

As mentioned earlier, many user-friendly Nattokinase supplements have pleasant tastes and easy usage. All you need to do is choose a product that suits you best.

However, there are some things to consider when using these products:

Seek medical advice: Before adding any new supplement to your regimen, consulting healthcare professionals is crucial, especially if you have underlying health issues or are taking medications.

Dosage Guidance: Adhere to the recommended dosage instructions provided by the manufacturer or your doctor.

Patience is Key: Consistent use of Nattokinase supplements over a prolonged period may yield optimal results for skin health. So, persevere to achieve healthier skin!

Other Potential Benefits of Nattokinase

Besides the benefits to your skin, Nattokinase offers various other interesting and positive impacts on your body, such as:

Heart Health Support: Nattokinase promotes cardiovascular health by supporting healthy blood circulation and maintaining ideal blood pressure levels. This is why it's included in the diet of some individuals with cardiovascular issues.

Joint Health Support: Some studies suggest that Nattokinase may have beneficial anti-inflammatory properties, particularly for joint health and flexibility.

Digestive Health: Due to its probiotic content, Natto may support gut health and digestion, reducing symptoms like bloating, indigestion, and diarrhea and enhancing nutrient absorption.


In conclusion, scientific studies on the benefits of Nattokinase demonstrate its effectiveness in improving skin quality. Specifically, Nattokinase helps rejuvenate your skin, reduce wrinkles, synthesize skin pigments, and give you radiant and healthy skin.

Furthermore, Nattokinase offers other benefits for heart, digestion, and joint health, with diverse and suitable supplementation options for everyone.

However, these changes are internal and require a certain amount of time. So, be patient when using Nattokinase to see its benefits soon!


[1] Tokudome, Yoshihiro, et al. “Effects of Soybean Peptide and Collagen Peptide on Collagen Synthesis in Normal Human Dermal Fibroblasts.” International Journal of Food Sciences and Nutrition, vol. 63, no. 6, Jan. 2012, pp. 689–95.
[2] Hsu, Mei-Fang, and Been‐Huang Chiang. “Effect of Bacillus Subtilis Natto–fermented Radix Astragali on Collagen Production in Human Skin Fibroblasts.” Process Biochemistry, vol. 44, no. 1, Jan. 2009, pp. 83–90.
[3] Ghazali, S. R., Danial Iylia, & Rozaini, M. Z. (2022). Determination of Chemical and Physical Properties of Soybean as Skin Care Product. International Journal of Synergy in Engineering and Technology, 3(1), 88-94. Retrieved from
[4] Gluyas, Bill. “Japanese Skincare Is an Art.” Manuka Natural, 5 Feb. 2023,
[5] Igari, Naoki, et al. “Effects of Dietary Bacillus Natto Productive Protein on the Skin: In Vitro Efficacy Test and Single-Armed Trial.” Cosmetics, vol. 10, no. 5, Sept. 2023, p. 135.
[6] Jang, Ja‐Young, et al. “Nattokinase Improves Blood Flow by Inhibiting Platelet Aggregation and Thrombus Formation.” Laboratory Animal Research, vol. 29, no. 4, Jan. 2013, p. 221.
[7] Afzaal, Muhammad, et al. “Nutritional Health Perspective of Natto: A Critical Review.” Biochemistry Research International, vol. 2022, Oct. 2022, pp. 1–9.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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