Red Vine Leaf Benefits - The Comprehensive Overview

Red Vine Leaf Benefits - The Comprehensive Overview

Red vine leaf has been used for centuries in traditional medicine to treat various health issues. Additionally, this plant offers various benefits that can help promote better physical and mental health. From aiding digestive problems to reducing high blood pressure levels, there's something about red vine leaves that can benefit all of us. In this blog post, we'll discuss the comprehensive overview of red vine leaf benefits so you understand it better before incorporating it into your wellness regime!


What Is Red Vine Leaf?

Red vine leaf (Vitis vinifera) is a perennial plant found growing throughout many parts of the world. It has been used since ancient times for medicinal purposes, particularly as an herbal remedy for various ailments. Red vine leaves contain vitamins and minerals, including polyphenols, carotenoids, flavonoids, and anthocyanin. 

The Origin of Red Vine Leaf

Red Vine Leaf Has Been A Medicinal Remedy Since Ancient Time

Red vine leaf is an herb native to the Mediterranean area and is used around the world for its health benefits. This plant has been a medicinal remedy since ancient times, with evidence pointing to the Egyptians as one of the first civilizations to utilize red vine leaf for healing purposes. In modern times, red vine leaf continues to be prized for its various beneficial properties, including its ability to address a wide range of medical issues.

The special characteristic of red vine leaves compared to other grape varieties is that their leaves turn red when autumn arrives. The harvesting of red vine leaves takes place from May to September, during the autumn season, with the leaves being particularly beautiful and vibrant in color in September.

People utilize all parts of the red grapevine for medicinal purposes, with the most common use being the red vine leaves in beauty and cosmetics due to their beneficial effects on the skin and collagen production. 

Active Compound of Read Vine Leaf

One of the common compounds found in red vine leaves is polyphenols. These are the largest group of naturally occurring antioxidants with anti-inflammatory properties. The two common types of polyphenols in red vine leaves are flavonoids and stilbenes.

Polyphenols Is The Common Compounds Found In Red Vine Leaves

Notably, polyphenolic compounds like anthocyanins, catechins, and resveratrol (belonging to the stilbenes group) play significant roles in the leaves. Red vine leaves also contain many tannins from the catechin group. The tannin composition in the leaves depends on the plant's growth conditions and location.

In red vine leaves, organic acids, primarily malic and oxalic acids and tartaric acids, are present. Citric, fumaric, and succinic acids can be detected in trace amounts in the leaves. Grape leaves are richer in carotenoids and vitamin C than grape berries.

Thanks to these compounds, red vine leaf extracts offer a multitude of significant benefits, such as protection against UV-A and UV-B radiation in HaCaT cells. These radiations can be harmful to skin cells, causing cell death, aging, and skin cancer in humans.

The high polyphenol content also helps inhibit platelet aggregation, reduce the risk of heart disease, boost the immune system, provide antioxidant effects, control blood pressure, and combat aging.

To delve deeper into the effects of red vine leaves on human health, please continue reading in the next section.

Summary: Red vine leaf, a medicinal plant native to the Mediterranean, is renowned worldwide for its health benefits. With rich contents of polyphenols, carotenoids, and vitamins, it offers a range of benefits from boosting the immune system to anti-aging effects. Its extracts protect against harmful UV radiation and aid in controlling blood pressure. It has been a crucial part of wellness regimes since ancient Egyptian times.

5 Red Vine Leaf Benefits

Benefits For Patients with CVI And Varicose Veins

Red vine leaf has significantly benefited patients with Chronic Venous Insufficiency (CVI) and varicose veins. It is rich in flavonoids and antioxidants, which are known to strengthen blood vessels and reduce inflammation. 

In line with a study conducted by Tatsuro Hoshino and his team [9], red vine leaf extract has shown potential for combating edema and has antihistamine properties, which can be particularly beneficial for patients with Chronic Venous Insufficiency (CVI). The study also emphasized the extract's influence on the blood clotting system. 

A systematic review titled "Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency" encompassed 56 studies and 5 trials and provided significant evidence of the extract's benefits [10]. 

These included reductions in calf volume, calf circumference, ankle circumference, and symptoms such as fatigue, leg heaviness, itching sensation, pain, and feelings of tightness in the legs. The study concluded that red vine leaf extract offers potential benefits for patients suffering from CVI. 

Furthermore, a broader study [11] focusing on the role of natural components in inflammation and CVI underscored the importance of flavonoids for vascular health. It specifically mentioned red vine leaf as an extract rich in flavonoids that effectively treats varicose veins. Therefore, the research strongly suggests that red vine leaf extract is a promising natural remedy for CVI and varicose veins.

Regular consumption of red vine leaf extract has been associated with a decrease in the heaviness and swelling in the legs, symptoms typically present in CVI and varicose veins. 

Moreover, it may enhance the overall vascular system, promoting better circulation and preventing the formation of harmful blood clots. Thus, adding red vine leaf to your diet may be a practical, natural way to alleviate the discomfort associated with CVI and varicose veins.

Antioxidant Power

Antioxidant Power Of Red Vine Leaf Is One Of Its Most Prominent Benefits

The antioxidant power of Red Vine Leaf is one of its most prominent benefits, deriving mainly from its high phenolic compound content, universally recognized as a potent natural antioxidant and anti-inflammatories. 

According to a study titled "Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves" [3], Vitis vinifera leaf extract effectively reduced cholesterol levels and enhanced HDL in experimental atherosclerosis in mice. 

This cholesterol-lowering effect can be credited to the presence of active antioxidant components found in red vine leaves.

Moreover, an additional study [4] shed light on the heightened levels of phenols, flavonoids, and stilbenes present in September, indicating that red vine leaves harvested during this period offer an abundant source of antioxidants and antibacterial agents at a low cost. 

Simultaneously, the data from Maria Monagas' paper [4] further corroborates the acclaimed antioxidant properties of red vine leaves. These findings suggest that the antioxidant power of red vine leaves extends beyond boosting the immune system, also playing a vital role in managing cholesterol levels and providing antibacterial benefits.

Anti-Inflammatory Effects

Red vine leaf possesses remarkable anti-inflammatory properties, primarily due to the presence of polyphenols. These compounds are known to inhibit the production of pro-inflammatory cytokines, molecules that promote inflammation in the body [8]. By reducing the levels of these cytokines, red vine leaves can help alleviate inflammation and associated pain.

Substantiated by several studies, red vine leaf has demonstrated significant anti-inflammatory effects, particularly in the context of gastric and intestinal inflammation. A particular research study, Study [6], investigated the biological activities of a water extract derived from dried Vitis Vinifera leaves (VVWE). The findings concluded that this extract plays a pivotal role in inhibiting and reducing gastric inflammation.

Another review of Vitis Vinifera Red Vine Leaf, the "Review," has listed the pharmacological activity of grape leaf extract as anti-inflammatory based on the research conducted by Moldovan and colleagues in 2020 [1].

Further evidence from a 2019 study [7] highlighted the inhibitory effects of red vine leaf extract on the NF-KB pathway, particularly at the skin level. The research suggested that VVWE reduces keratinocyte damage and exhibits antioxidant activity. It effectively combats the harmful effects of H2O2 and UVB radiation, fosters tissue regeneration, and simultaneously curbs other signs of inflammation.

In addition, another study [8] endorsed the antioxidant properties, cellular protection, and anti-inflammatory characteristics of the vine leaf extract. This research highlighted the biological components of the extract, namely flavonoids, polyphenols, and anthocyanins, as the active agents contributing to these beneficial effects.

The anti-inflammatory effects of red vine leaf make it a potentially valuable natural remedy for numerous health conditions where inflammation plays a key role, such as arthritis, heart disease, and certain skin disorders. 


Red Vine Leaf Extract Is Considered To Be Beneficial For Anti-Diabetic

Red vine leaf demonstrates significant potential in managing diabetes, exhibiting both acute and subacute hypoglycemic effects. 

According to a study [5], two different doses (250 and 500 mg/kg) of an extract from Vitis Vinifera leaves were evaluated, and the results underscored the extract's hypoglycemic and antioxidant properties when tested on diabetic mice. This suggests that red vine leaves, abundant in polyphenols, can substantially impact blood sugar regulation.

Further supporting this notion, research [12] focused on Antistax, a dried vine leaf extract, and mentioned red vine leaf extract's antidiabetic, diuretic, and herpetic activity. This particular study emphasized the hepatoprotective effects of the extract, illustrating its potential in managing diabetes-induced liver damage.

Moreover, a study conducted by Devi, Sushma, and colleagues [13] evaluated the potential of Vitis vinifera leaf extracts as an antidiabetic agent. The study concluded that red vine leaf is a promising functional food and a potential pharmaceutical agent in the management of diabetes. 

Cardiovascular Health and Cancer Prevention

The potent antioxidants in red vine leaf can help protect the cardiovascular system from oxidative damage. The antioxidant activity of polyphenols found in red vine leaves has been proven to reduce LDL cholesterol levels and significantly enhance HDL cholesterol levels [2]. 

In addition, a study identified tannins as one of the active components responsible for inhibiting platelet aggregation and lowering the risk of arterial thrombosis, indicating that red vine leaves may offer protection from heart attack and stroke. 

In addition to its cardiovascular benefits, red vine leaf has also shown promise as a potential cancer inhibitor. At the heart of this is resveratrol, a potent antioxidant found in red vine leaves, which has been linked to the prevention of tumor formation [2]. 

The anticancer effects of resveratrol are primarily attributed to its ability to interrupt the oxidative chain reactions, believed to initiate carcinogenesis [2. 

Further research is, however, required to fully understand its implications, dosage, and mechanisms of action concerning cancer prevention.

Summary: Red vine leaves are a rich source of beneficial compounds, offering a range of health benefits. They are known for their potent antioxidant and anti-inflammatory properties, aiding in the maintenance of good health, especially for varicose veins or CVI. These leaves also exhibit significant anti-diabetic effects and can aid in cardiovascular health and potentially in cancer prevention. Further research is required to fully explore and understand their potential as a natural healthcare remedy. 

Red Vine Leaf Extract Side Effects

While red vine leaf has been lauded for its numerous health benefits, it is important to also consider potential side effects. Due to the limited research available on the topic, our understanding of these side effects is somewhat restricted. 

However, extensive studies have been conducted on Antistax [14], a well-known red vine leaf extract, approved for treating conditions like Chronic Venous Insufficiency (CVI). 

The findings from these studies indicate that most patients tolerate Antistax well when consumed orally, with no serious adverse effects reported. 

Some mild side effects, albeit occasionally reported, include gastrointestinal disturbances characterized by occasional nausea and stomach discomfort. 

Furthermore, hypersensitivity reactions have also been recorded, indicating that individuals with a history of such reactions should exercise caution when considering the use of red vine leaf. 

Nonetheless, given the preliminary nature of these findings, further research is necessary to comprehensively understand the potential side effects of red vine leaf.

Summary: Red vine leaf extract, notably Antistax, is generally well-tolerated, with mild side effects including occasional gastrointestinal disturbances and hypersensitivity reactions. Individuals with a history of hypersensitivity should use caution. Further research is necessary to fully understand the potential side effects.

Suitable Dosage to Avoid Possible Side Effects of Red Vine Leaf

How Much Should You Take Red Vine Leaf Per Day?

Recommended daily dosages for red vine leaf extract are largely based on scientific studies and can vary depending on the health condition being addressed. 

Multiple studies, including one that evaluated its safety and effectiveness, have indicated that a daily dosage of 360 mg to 720 mg of red vine leaf extract can significantly improve mild Chronic Venous Insufficiency (CVI) conditions [14]. 

This study also showed that the higher dose, although more substantial, was well-tolerated and provided more sustainable improvements than the lower 360 mg dose [14]. 

Similarly, a double-blind study found that a daily dose of 720mg over 12 weeks improved leg volume and leg pain in participants [15]. 

Hence, it can be inferred that a safe and effective red vine leaf extract dosage range is approximately 360-720 mg daily.

Who Is Suitable for Taking Red Vine Leaf?

Those who may benefit from taking red vine leaf are individuals suffering from Chronic Venous Insufficiency (CVI), as red vine leaf extract has been shown to alleviate symptoms and improve the condition. 

People at risk of cardiovascular diseases, such as heart attack and stroke, may also find red vine leaf beneficial due to its property of inhibiting platelet aggregation. 

Additionally, given its hypoglycemic effects, individuals with diabetes or at high risk of diabetes could consider incorporating red vine leaf into their management regimen. 

However, it's worth noting that individuals with a history of hypersensitivity reactions or gastrointestinal disturbances should exercise caution. 

Always Consult With Your Healthcare When Taking Red Vine Leaf Extract

Summary: Red vine leaf extract is beneficial for individuals with Chronic Venous Insufficiency (CVI), cardiovascular risks, and diabetes, with a suggested dosage of 360-720 mg per day. This recommended daily intake is based on several scientific studies and is well-tolerated by the body. However, people experiencing hypersensitivity reactions or gastrointestinal disturbances should use it cautiously.

Should You Use Red Vine Leaf?

Red vine leaf extract has shown potential in the treatment of various health conditions, including Chronic Venous Insufficiency (CVI), diabetes, and cardiovascular diseases. 

Its antioxidant content can also help reduce oxidative damage and protect cells from carcinogenesis. Thus, within the recommended dosage range of 360-720 mg per day, red vine leaf may be a useful supplement for those looking to improve their health and well-being. 

However, individuals should discuss with a healthcare professional prior to incorporating red vine leaf into their diet, as there is still some uncertainty regarding its safety and potential side effects. Additionally, further research would be needed to better understand the implications of long-term use of this supplement. 


How Long Is It Safe to Use Red Vine Leaf Extract?

The safety of the long-term use of red vine leaf extract is still under investigation. However, short-term use (up to 12 weeks) has been deemed safe in various studies. Always consult a healthcare professional before beginning any new supplement regimen.

Does Red Vine Leaf Extract Make Your Blood Thinner?

Red vine leaf extract does not directly thin your blood. However, it contains high levels of flavonoids, which are known to improve blood circulation and prevent clot formation. It's essential to consult a healthcare provider before using it, especially if you're on blood-thinning medication.

What Makes Red Vine Leaf Extract Work?

Red vine leaf extract works primarily due to its rich composition of bioactive compounds like flavonoids, polyphenols, and anthocyanins. These compounds exhibit potent anti-inflammatory, antioxidant, and anti-diabetic properties. Additionally, they contribute to cardiovascular health and potentially aid in cancer prevention.

Can Red Vines Affect Your Cholesterol in A Bad Way?

Red vine leaves are rich in antioxidants known to reduce LDL (bad) cholesterol levels and enhance HDL (good) cholesterol levels. Thus, red vine leaf extract is unlikely to negatively affect your cholesterol when incorporated into a balanced diet and lifestyle. 


Red vine leaf extract possesses various biological activities, including anti-inflammatory, antioxidant, antidiabetic, diuretic, and hepatoprotective properties. It is also beneficial for cardiovascular health and cancer prevention due to its high polyphenol and flavonoid content. While short-term red vine leaf extract use appears safe, further research is needed to determine its long-term safety. If you're considering incorporating red vine leaf into your diet, consult a healthcare professional for guidance on the recommended dosage and potential health benefits. 


[1] Parihar, S., & Sharma, D. (2021). A Breif Overview on Vitis vinifera. Scholars Academic Journal of Pharmacy, 10(12), 231–239.
[2] Lardo, A., & Kreute, M. (n.d.). Red vine leaf. Retrieved November 29, 2023, from
[3] Francisco Maximino Fernandes, Ramalhosa, E., Daniela, João Verdial, Patrı́cia Valentão, Andrade, P. B., Bento, A., & José Alberto Pereira. (2013). Vitis vinifera leaves towards bioactivity. Industrial Crops and Products, 43, 434–440.
[4] Commercial Dietary Ingredients from Vitis vinifera L. Leaves and Grape Skins:  Antioxidant and Chemical Characterization. (2015). ACS Publications.
[5] Nilüfer Orhan, Aslan, M., Didem Deliorman Orhan, Fatma Ergün, & Erdem Yeşilada. (2006). In-vivo assessment of antidiabetic and antioxidant activities of grapevine leaves (Vitis vinifera) in diabetic rats. Journal of Ethnopharmacology, 108(2), 280–286.
[6] Sangiovanni, E., Chiara Di Lorenzo, Colombo, E., Colombo, F., Fumagalli, M., Frigerio, G., Restani, P., & Dell’Agli, M. (2015). The effect of in vitro gastrointestinal digestion on the anti-inflammatory activity of Vitis vinifera L. leaves. Food & Function, 6(8), 2453–2463.
[7] Sangiovanni, E., Chiara Di Lorenzo, Piazza, S., Manzoni, Y., Brunelli, C., Fumagalli, M., Magnavacca, A., Martinelli, G., Colombo, F., Antonella Casiraghi, Melzi, G., Marabini, L., Restani, P., & Dell’Agli, M. (2019). Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases. Antioxidants, 8(5), 134–134.
[8] Sangiovanni, E., Chiara Di Lorenzo, Piazza, S., Manzoni, Y., Brunelli, C., Fumagalli, M., Magnavacca, A., Martinelli, G., Colombo, F., Antonella Casiraghi, Melzi, G., Marabini, L., Restani, P., & Dell’Agli, M. (2019). Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases. Antioxidants, 8(5), 134–134.
[9] Hoshino, T., Muto, N., Tsukada, S., Nakamura, T., & Hikoichiro Maegawa. (2018). European Ethnopharmaceuticals for Self-Medication in Japan: Review Experience of Vitis vinifera L., Folium Extract and Vitex agnus-castus L., Fructus Extract as OTC Drugs. Medicines, 5(1), 3–3.
[10] Azhdari, M., Marzie Zilaee, Majid Karandish, Seyed Ahmad Hosseini, Mansoori, A., Mohadeseh Zendehdel, & Khodarahpour, S. (2020). Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. Phytotherapy Research, 34(10), 2577–2585.
[11] Lichota, A., Łukasz Gwoździński, & Krzysztof Gwoździński. (2019). Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. European Journal of Medicinal Chemistry, 176, 68–91.
[12] Ahmed, A. F., Al‐Yousef, H. M., Alqahtani, J., Alsaid, M. S., Ashour, A. E., Al-Sohaibani, M., & Syed Rafatullah. (2015). Hepatorenal protective effect of Antistax®against chemically-induced toxicity. Pharmacognosy Magazine, 11(42), 173–173.
[13] Evaluation of antidiabetic potential of Vitis vinifera leaves extracts in acute and chronic animal models - ProQuest. (2017).
[14] Stücker, M., Rabe, E., Meyer, K. C., Ottillinger, B., & Schütt, T. (2019). Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). PubMed, 74(4), 193–200.
[15] Rabe, E., Stücker, M., Anke Esperester, Elmar Schäfer, & Ottillinger, B. (2011). Efficacy and Tolerability of a Red-vine-leaf Extract in Patients Suffering from Chronic Venous Insufficiency – Results of a Double-blind Placebo-controlled Study. European Journal of Vascular and Endovascular Surgery, 41(4), 540–547.
Back to blog


Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

About me!


The information provided in this blog post is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

The content of this blog post has not been evaluated by the Food and Drug Administration (FDA). The dietary supplement products mentioned on this website are separate from the content of this blog post and are not directly endorsed or associated with the information presented here. 

Any claims, statements, or opinions expressed in this blog post are those of the author(s) and do not necessarily reflect the views or opinions of the manufacturers of the dietary supplement products. The products sold on this website are formulated based on scientific research and adhere to FDA guidelines for dietary supplements. However, the content of this blog post is not intended to promote or endorse any specific product. 

It is recommended that individuals consult with a qualified healthcare professional before making any dietary or lifestyle changes, including the use of dietary supplements. The authors, website, and manufacturers of the dietary supplement products do not assume any liability for any potential consequences arising from the use of the information provided in this blog post. 

By accessing and reading this blog post, you acknowledge and agree to the terms of this disclaimer. This disclaimer is subject to change without notice. 

Please refer to the product labels and packaging for specific usage instructions and guidelines for the dietary supplement products sold on this website. Any products sold on this website are not intended to diagnose, treat, cure, or prevent any disease.

For any concerns or questions regarding the dietary supplement products, it is advisable to contact the customer support team, who will be more than happy to assist you.