red vine leaf extract for varicose veins

Red Vine Leaf Extract For Varicose Veins - Spider Veins - CVI

Are you troubled by the appearance of varicose veins, spider veins, cradle cap or chronic venous insufficiency (CVI)? If so, you may have heard about an extract from red vine leaves that is receiving much interest in the medical community for its potential effectiveness in treating these conditions. In this blog post, we will discuss what red vine leaf extract is and how it can be used to effectively treat varicose veins, spider and reticular veins, as well as CVI. We will also provide tips on using this herbal supplement safely with other medications. Read on to find out more!


Varicose Veins, Spider Veins and CVI Overview

Varicose Veins

Varicose veins are enlarged, swollen, and twisted veins that typically appear as blue or dark purple. They commonly manifest in the legs, causing discomfort, pain, or a feeling of heaviness. The underlying cause of varicose veins is damaged valves within the veins, which disrupts proper blood flow and leads to blood pooling. This, in turn, gives rise to the noticeable bulging appearance of varicose veins.

Varicose Veins That Typically Appear As Blue Or Dark Purple Veins

Spider Veins

Spider veins, medically referred to as telangiectasias, are characterized by their smaller and more delicate nature compared to varicose veins. These veins tend to be more superficial, resembling intricate spider webs or branching tree patterns. Typically, spider veins exhibit hues of red or blue and commonly appear on the face or legs.

Chronic Venous Insufficiency (CVI)

Chronic venous insufficiency (CVI) is a condition in which the veins have difficulty returning blood to the heart. It is usually caused by damaged or weakened valves in the veins, which can be a result of varicose veins or other factors such as family history, obesity, pregnancy, and prolonged standing or sitting.

Symptoms and Prevention

All three conditions are related to the swelling and pooling of blood in the leg veins, but they differ in severity and underlying causes. In general, varicose veins, chronic venous insufficiency (CVI), and spider veins share essential connections and characteristics, so they can be prevented or minimized through similar measures. Here are some symptoms of varicose veins, spider veins, and CVI:

Varicose veins:

  • Large, bulging veins
  • Twisted or rope-like appearance
  • Pain, aching, or throbbing in legs, especially after standing for long periods
  • Swelling or edema in ankles and lower legs
  • Itching or feeling of heaviness in the affected leg
  • Skin discoloration or changes near affected veins

Spider veins:

  • Small, thin veins close to the surface of the skin
  • Resemble spider webs or tree branches
  • Mild burning or itching sensations in the affected area
  • Generally, it is more of a cosmetic concern

Chronic venous insufficiency (CVI):

  • Swelling in lower legs and ankles
  • Dryness, redness, or darkening of the skin
  • Open sores or ulcers may appear, particularly near the ankles
  • Pain or feeling of heaviness in legs, especially when walking or standing for extended periods
  • If left untreated, symptoms can progress and lead to more severe complications.

Cvi Appears To Be More Serious Than Spider Veins And Varicose Veins

All three of these conditions can cause both health and aesthetic issues for individuals, especially women. Numerous methods have been proposed to prevent or minimize the symptoms associated with these conditions, ranging from mild to severe. In particular, to prevent or alleviate symptoms in mild to moderate cases, many people turn to natural herbal remedies. 

One such remedy gaining attention for its potential benefits is red vine leaf extract. But how effective is red vine leaf extract in treating varicose veins, spider veins, or CVI? Let's explore.

Red Vine Leaf Background

Red vine leaf extract comes from the dried leaves of the red grapevine, or Vitis vinifera, and is commonly used in traditional medicine. It contains a variety of active substances, including flavonoids and organic acids, that have been shown to have anti-inflammatory and antioxidant properties.

Red Vine Leaf Extract Is Supposed To Be Beneficial For Varicose Veins, Spider Veins And CVI

Red Vine Leaf Extract Benefits

In this section, we will explore the potential health benefits of red vine leaf extract. Let's uncover the key advantages that this extract has to offer:

  • Benefits for Patients with CVI and Varicose Veins: The flavonoids present in red vine leaf extract can help reduce swelling and inflammation in the veins, making it beneficial for patients dealing with CVI and varicose veins. This can lead to a significant decrease in discomfort and an improvement in the overall appearance of the affected veins.
  • Antioxidant Properties: The extract is rich in antioxidants. These compounds combat free radicals in the body, which can lead to cellular damage and a range of health issues. A daily dose of red vine leaf extract can increase the body's antioxidant capacity, contributing to overall health.
  • Alleviating Inflammation: The anti-inflammatory properties of red vine leaf extract can ease the symptoms of various health conditions. This extract can help in reducing redness, swelling, and pain associated with inflammation.
  • Diabetes Management: Some studies suggest that red vine leaf extract may help in managing blood sugar levels, providing potential benefits for those with diabetes.
  • Promoting Cardiovascular Well-being: The extract's health benefits extend to cardiovascular health. It can help strengthen the walls of blood vessels and improve circulation, promoting overall heart health.
  • Reducing Cancer Risk: While more research is needed, preliminary studies hint that the antioxidant properties of red vine leaf extract could potentially contribute to a reduced risk of certain types of cancer. 

While the benefits of red vine leaf extract have been widely touted, its effectiveness in treating conditions like varicose veins, spider veins, and CVI is a matter of ongoing debate. 

In the upcoming section, we'll delve into available research and scientific evidence to answer the question: Is Red Vine Leaf Extract For Varicose Veins, Spider Veins, and CVI Really Work?

Red Vine Leaf Extract For Varicose Veins - Spider Veins and CVI? Is It Really Work?

Research Evidence 

There is a growing body of research that supports the potential benefits of red vine leaf extract in treating varicose veins, spider veins, and CVI. 

Maryam Azhdari and colleagues [1] found that Red Vine Leaf extract can improve certain signs and symptoms of CVI and varicose veins. A comprehensive study that analyzed data from 56 research papers and 5 clinical trials reported positive outcomes. 

These included significant reductions in calf volume, lower leg circumference, ankle edema, and symptoms such as leg fatigue, heaviness, itching, and pain. The study also reported an improvement in skin microcirculation and a decrease in oxidative pressure through the skin [1].

In a broader context, a study on Chronic Venous Disorders or Diseases (CVD), which include varicose veins and CVI, found that Antistax195 (a specific type of red vine leaf extract) preserves endothelial function, inhibits inflammation and thrombus formation – all of which contribute to the progression of CVD [2]. 

A double-blind study conducted in 2011 also reported positive results, with 248 patients experiencing reduced calf volume and relief from leg pain symptoms after 12 weeks of treatment [3]. 

In a review by M. Butcher, the effectiveness of red vine leaf extract for CVI was recognized. The author suggests that the properties of AS 195 (a type of red vine leaf extract) may have a preventive effect on venous hypertension and improve existing conditions [4]. 

Moreover, a study lists red vine leaf as one of the most commonly used flavonoid extracts for varicose veins, alongside oxerutin, b-hydroxyethylrutosides, and pycnogenol [5]. 

Lastly, a Japanese study by Tatsuro Hoshino demonstrated the ability of red vine leaf to combat edema and histamine resistance, highlighting its promise for CVI [6]. This research also emphasized the impact of Red Vine Leaf on the coagulation system, suggesting its further potential benefits in managing these venous conditions.

It's clear that while more research is needed, current evidence indicates that red vine leaf extract could be a useful tool in managing and treating CVI, varicose veins, and spider veins.

Mechanism of Red Vine Leaf Extract for Varicose Veins, Spider Veins, and CVI 

Red vine leaf extract works in several ways to assist in the management and treatment of Chronic Venous Insufficiency (CVI), varicose veins, and spider veins.

Anti-inflammatory and Antioxidant Activity

The flavonoids found in red vine leaf extract exhibit antioxidant properties that protect the body's cells from damage caused by free radicals. These flavonoids also possess anti-inflammatory capabilities, aiding in the reduction of swelling and inflammation within the veins, which is a characteristic feature of CVI and varicose veins. This activity can decrease discomfort and improve the overall appearance of the affected veins.

Improve Blood Circulation

Red vine leaf extract may contribute to improved blood circulation. It is believed to strengthen the walls of blood vessels, thereby promoting overall heart health. Enhanced blood circulation can alleviate the symptoms associated with varicose veins and CVI, including leg fatigue, heaviness, and pain.

Improve Blood Circulation Is One Of Red Vine Leaf Benefits For Varicose Veins

Inhibition of Thrombus Formation

One of the potential mechanisms of red vine leaf extract is its capacity to inhibit thrombus (blood clot) formation. This suggests that it could be useful in the management of CVI and varicose veins, where blood clots can contribute to the progression of the condition.

Reduction in Leg Volume and Relief from Pain

Research has shown that the extract can result in reduced calf volume and lower leg circumference, providing relief from leg pain symptoms. This is particularly beneficial for individuals with CVI, varicose veins, and spider veins. 

While these mechanisms offer promising outcomes, more research is needed to fully understand the precise ways in which red vine leaf extract can benefit those with CVI, varicose veins, and spider veins. 

Adverse Effects That May Happen When Taking Red Vine Leaf Extract for Varicose Veins

While red vine leaf extract is generally well-tolerated, some side effects have been reported. These include mild gastrointestinal discomfort such as nausea, stomach pain, or diarrhea. 

There are also concerns about potential interactions with medications and supplements that could increase the risk of bleeding disorders or lowered blood sugar levels. Therefore, it is crucial to consult with a healthcare professional before incorporating red vine leaf extract into your treatment plan. 

How To Use Red Vine Leaf Extract For Varicose Veins?

If you suffer from varicose veins, then you're probably aware of how uncomfortable and unsightly they can be. Fortunately, red vine leaf extract may help alleviate the symptoms and improve the appearance of your veins.

But how exactly do you use red vine leaf extract for varicose veins? Here are some tips to help you get started:

Choose a High-Quality Extract

When purchasing red vine leaf extract, make sure to choose a high-quality product from a reputable brand. 

Besides, many products blend red vine leaf extract with other extracts. It is important to consider whether the additional ingredients have specific effects on varicose veins in particular and overall health. One of the extracts that synergize well with red vine leaf for varicose veins is horse chestnut.

Looking For Quality Red Vine Leaf Extract Supplement Is Important

Follow the Recommended Dosage

The recommended dosage of red vine leaf extract for varicose veins is typically 360 mg per day. However, you should always follow the instructions on the product label or consult with a healthcare professional before starting any new supplement regimen.

Take it Consistently

For best results, take it once daily or divide your daily dose into smaller doses throughout the day. Consistency is key in allowing the active compounds to build up in your system and provide maximum benefits.

Combine with Other Varicose Vein Treatments

While red vine leaf extract may help improve varicose veins on its own, it may be more effective when used in combination with other treatments. For example, you could also try compression stockings, leg exercises, or dietary changes to support the health of your veins.

Be Patient

Like with any natural remedy, results may not be immediate. It may take a few weeks or even months of consistent use before you see noticeable improvements in your varicose veins. Don't get discouraged, and continue using the extract as directed for the best chance of seeing results.

Other Alternative Methods

Horse Chestnut Extract

Similar to red vine leaf extract, horse chestnut has been traditionally used for its anti-inflammatory and antioxidant properties. It is believed to improve blood circulation and reduce swelling in the legs, making it a popular remedy for varicose veins.

The Combine Of Horse Chestnut And Red Vine Leaf Is Good For Reduce Varicose Veins Symptoms

Rutin/ Rutoside

A type of flavonoid, rutin, has been shown to have anti-inflammatory and antioxidant effects. It is often used in combination with horse chestnut or other natural remedies for varicose veins.

Gotu Kola

Gotu kola is a traditional herb used in Ayurvedic and Traditional Chinese Medicine for its circulatory benefits. It may also improve collagen production, which can strengthen the walls of blood vessels.

Butcher's Broom

Butcher's broom contains compounds called ruscogenins, which are believed to improve circulation and reduce inflammation. It is often used in combination with other natural remedies for varicose veins.

Massage Therapy

Massage therapy can help alleviate symptoms of varicose veins by improving blood flow and reducing tension in the muscles. It can also provide relief from pain and heaviness in the legs.

Lifestyle Changes

Lifestyle changes such as maintaining a healthy weight, staying physically active, and avoiding prolonged periods of sitting or standing can help prevent and manage varicose veins. 


How Long Does It Take For Red Vine Leaf To Work?

The duration before seeing results from Red Vine Leaf extract can vary depending on the individual and the severity of their varicose veins. However, on average, most people begin to notice improvements after 6 to 8 weeks of consistent use.

Does Red Vine Leaf Help With Circulation?

Red Vine Leaf Extract has been shown to improve blood circulation. It helps to strengthen blood vessels, promote blood flow, and prevent the formation of blood clots, all of which can contribute to better overall circulation.

Is Red Vine Leaf Extract The Same As Resveratrol?

Red vine leaf extract is abundant in resveratrol, a compound with antioxidant properties. The leaf is the active part of the red vine and contains polyphenols and flavonoids. These components support various organs and contribute to improved circulation through the strengthening of blood vessel walls.

When Should I Be Worried About Varicose Veins?

Varicose veins are usually not a serious condition, but you should seek medical attention if you have severe pain, if your veins become warm and feel tender to the touch, or if skin changes occur, such as color changes or thickening. Also, seek immediate medical help if you have any bleeding or ulcers in the areas of your varicose veins.


Incorporating red vine leaf extract into your daily routine may provide relief from varicose veins and improve the overall appearance of your legs. However, it's important to remember that different alternatives work for different individuals, so be patient and consult with a healthcare professional before starting any new supplement regimen. With consistent use and healthy lifestyle changes, you can hopefully find some relief from the discomfort and appearance of varicose veins. So, keep exploring your options and find what works best for you! 


[1] Azhdari, M., Marzie Zilaee, Majid Karandish, Seyed Ahmad Hosseini, Mansoori, A., Mohadeseh Zendehdel, & Khodarahpour, S. (2020). Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. Phytotherapy Research, 34(10), 2577–2585.
[2] Stücker, M., Rabe, E., Meyer, K. C., Ottillinger, B., & Schütt, T. (2019). Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). PubMed, 74(4), 193–200.
[3] Rabe, E., Stücker, M., Anke Esperester, Elmar Schäfer, & Ottillinger, B. (2011). Efficacy and Tolerability of a Red-vine-leaf Extract in Patients Suffering from Chronic Venous Insufficiency – Results of a Double-blind Placebo-controlled Study. European Journal of Vascular and Endovascular Surgery, 41(4), 540–547.
[4] A review of evidence on red vine leaf extract in the prevention and management of venous disease. (2020). Journal of Wound Care.
[5] Lichota, A., Łukasz Gwoździński, & Krzysztof Gwoździński. (2019). Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. European Journal of Medicinal Chemistry, 176, 68–91.
[6] Hoshino, T., Muto, N., Tsukada, S., Nakamura, T., & Hikoichiro Maegawa. (2018). European Ethnopharmaceuticals for Self-Medication in Japan: Review Experience of Vitis vinifera L., Folium Extract and Vitex agnus-castus L., Fructus Extract as OTC Drugs. Medicines, 5(1), 3–3.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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