Benefits of TUDCA for Weight Loss

The Benefits of TUDCA for Weight Loss: Is It Really Effective?

One intriguing benefit of TUDCA is its potential to help with weight loss. Tauroursodeoxycholic Acid (TUDCA) helps improve liver function, boost metabolism, and reduce inflammation. These improvements not only help the body function more efficiently but may also contribute to weight control. The following article will clarify the role of TUDCA in weight management.


Key Takeaways

  • TUDCA and Liver Health: TUDCA is a bile acid that benefits liver health, indirectly supporting weight management by playing a crucial role in fat metabolism.
  • Improving Insulin Sensitivity: TUDCA helps improve insulin sensitivity, helping the body use insulin more effectively to regulate blood sugar levels. Low insulin sensitivity can lead to more fat storage; hence, improving it can support weight loss.
  • Comprehensive Approach: Effective and sustainable weight loss using TUDCA should be based on a healthy diet, regular exercise, and a scientific lifestyle.

Does TUDCA Help You Lose Weight?

tudca may support weight loss

Research indicates that TUDCA may support weight loss.

Studies on obese mouse models have shown that TUDCA increases insulin sensitivity [2].

Another study found that TUDCA could improve liver function, support metabolism, and reduce oxidative stress in the body.

These improvements can indirectly aid weight loss by making the body function more efficiently [1].

Besides improving metabolic parameters like insulin sensitivity, TUDCA is known for its liver-protective functions, which are vital for fat metabolism and body detoxification, potentially supporting weight loss.

What Are the Benefits of TUDCA for Weight Management?

benefits of tudca for weight loss

Based on studies, TUDCA offers the following potential benefits for weight management:

  • Supporting Liver Health: A healthy liver is crucial for fat metabolism, and TUDCA's liver-protective properties can indirectly aid in weight management.
  • Enhanced Protein Delivery and Cell Protection: TUDCA, a bile acid derivative used in Europe for treating gallstones and cholestatic liver diseases, enhances protein delivery and cell protection. In obese mice, TUDCA injections reduced endoplasmic reticulum stress, improved systemic insulin resistance, and lowered liver triglyceride levels [2].
  • Benefits for Diabetics, Obese, and Cardiovascular Patients: TUDCA can benefit patients with diabetes (due to improved insulin sensitivity), obesity, and cardiovascular diseases. [5].
  • Improved Digestion: TUDCA may enhance fat digestion, potentially leading to better nutrient absorption and reduced bloating [5].

How Does TUDCA Aid Weight Loss?

the mechanism of tudca for weight management

Most studies on TUDCA's weight loss effects have been conducted on animals, with limited research on humans.

However, TUDCA has been shown to mitigate obesity-related metabolic disorders by inhibiting endoplasmic reticulum stress and inflammation in adipose tissues.

TUDCA’s beneficial effects on perivascular adipose tissue function may contribute to cardiovascular protection in obese individuals. Thus, TUDCA has emerged as a potential supportive strategy for obesity and associated conditions [1].

Insulin resistance is commonly associated with obesity. Studies on obese mouse models show that endoplasmic reticulum stress contributes to insulin resistance, and using TUDCA reduces this stress, increasing insulin sensitivity [2].

How to Use TUDCA for Weight Loss?

how to use tudca for weight loss

Currently, there is a lack of specific information on using TUDCA for effective and safe weight loss in humans. However, based on potential mechanisms, consider the following:

  • Dosage: The optimal TUDCA dosage for weight loss is not clearly defined, but it typically ranges from 50 mg/kg/day, which aligns with acceptable human tolerance levels. The recommended human dose is 250-750 mg/day [4].
  • Diet and Lifestyle: When using TUDCA for weight loss, combine it with a diet low in sweets, fatty foods, and fast foods, and increase whole food consumption like vegetables and low-fat products.
  • Supplement Form: TUDCA is typically taken as a capsule supplement. Combining it with a healthy diet and regular exercise will enhance TUDCA’s weight loss benefits.

Frequently Asked Questions

Does TUDCA Help with Fat Absorption?

TUDCA does not directly affect fat absorption but supports the liver’s ability to metabolize and process fats, indirectly aiding weight control.

Can Bile Salts Help You Lose Weight?

Bile salts are crucial for fat digestion and absorption. Some studies show that specific bile salts, like TUDCA, support liver health and fat metabolism. Although not a magic bullet for weight loss, they are a valuable option in a weight management strategy [3].


Thanks to its ability to improve liver function, boost metabolism, and enhance insulin sensitivity, TUDCA shows promise for weight loss and offers benefits for obese, cardiovascular, and diabetic patients. While more research is needed to fully understand its efficacy and optimal usage, incorporating TUDCA with a healthy and scientific lifestyle can support your weight loss journey.


[1] Israelle Netto Freitas, et al. Insights by Which TUDCA Is a Potential Therapy against Adiposity. Vol. 14, 21 Feb. 2023,, Accessed 29 May 2023.
[2] Kars, Marleen, et al. “Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women.” Diabetes, vol. 59, no. 8, 3 June 2010, pp. 1899–1905,
[3] Macierzanka, Adam, et al. “Bile Salts in Digestion and Transport of Lipids.” Advances in Colloid and Interface Science, vol. 274, 1 Dec. 2019, p. 102045,,
[4] Cardoso, Isabel, et al. “Synergy of Combined Doxycycline/TUDCA Treatment in Lowering Transthyretin Deposition and Associated Biomarkers: Studies in FAP Mouse Models.” Journal of Translational Medicine, vol. 8, no. 1, 30 July 2010, Accessed 1 Nov. 2022.
[5] Rodolfo, Lucas, et al. “TUDCA Receptors and Their Role on Pancreatic Beta Cells.” Progress in Biophysics & Molecular Biology, vol. 167, 1 Dec. 2021, pp. 26–31, Accessed 20 Oct. 2023.
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Ralph S. Albert, with over 10 years of expertise in nutrition and research, now heads the Research division at Vinatura Supplements. His dedication and extensive knowledge ensure top-quality articles on nutrition and health, collaborating with a skilled team. He has successfully completed The VINATURA Expertise Research Training Program, underscoring his commitment to Vinatura's mission. Ralph has also published numerous articles and conducted valuable research in the field, making him a trusted resource for individuals on their wellness journey.

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